The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat…

The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously…

Advantages of Hot Melt Coating (HMC) One advantage for the pharmaceutical industry is the simplification of complex dosage schemes, as several active ingredients can be combined, even those that cannot normally be combined. As the…

Guidance for an excellent Hot Melt Coating Part 2 in the series of 3 articles In order to reduce the problems of other solvent-based coating processes, such as time and cost intensity, the active ingredient coating by means of Hot Melt…

Disadvantages of solvent-based coatings and why alternatives are needed The coating of active substances requires the suspension of the auxiliary substances in a solvent. This mixture is then applied to the active ingredient particles. If…

The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously…

About our company The Gattefossé Group is a community of employees, all driven by a dual mission: the performance of its products and the personalized support to its customers. Gattefossé develops, manufactures and sells cosmetic…

Abstract Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen…

Use of high melting point solid vegetable oils in encapsulation processes Introduction to encapsulation Encapsulation relates to technologies that enable the incorporation of a compound into individualized small particles.…

YOUR FORMULATION CHALLENGE - IOI Oleo SOLUTIONS According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or…