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Mannitol
The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized…
Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights into product performance, complementing traditional methods…
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw…
Abstract
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was…
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Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation…
Abstract
The mechanism governing pharmaceutical tablet disintegration is far from fully understood. Despite the importance of controlling a formulation's disintegration process to maximize the active pharmaceutical ingredient's bioavailability and ensure predictable and consistent release…
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Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the
freeze drying…
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation – In vitro…
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate to severe depression. MTZ is classified as a BCS class II…
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The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid…
Abstract
Amorphous solid dispersion (ASD) is an effective approach for enhancing the solubility, dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable forms can transform into more thermodynamically stable, less soluble crystalline forms. Despite this…
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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We…
Abstract
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful…
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Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
Abstract
Twin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive research conducted on the impact of screw geometry in melt…
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Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction
The Application of Fillers and Binders in Solid Dosage Formulation
Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties that offer greater flowability and compressibility which…
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Parteck® LM Excipient System – Reduce complexity in your formulation and optimize results
Discover our, Merck, new Parteck® LM Excipient System: This exceptional product offers excellent flow properties, ensuring reliable dosing in both batch and continuous processes. With its consistent dosing and robust, constant mixing times, Parteck® LM Excipient System supports a consistent…
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