Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage conditions with life-threatening complications, but no pharmacologic therapy has been approved. Drug delivery systems such as lipid nanocapsules (LNC) are very versatile platforms that are easy to…
Nordic Bioproducts Group opens its first major production facility for advanced cellulosic materials
PRESS RELEASE
April 24th, 2024
Finnish startup Nordic Bioproducts Group has opened its state-of-the-art production facility in Lappeenranta, Finland. This facility, powered by the company’s proprietary AaltoCellTM Technology, is…
Soluplus® as Promising Polymer for Topical Film Forming Solid Solutions of Betamethasone…
This poster was presented at the PBP World Meeting 2024 in Vienna:
BACKGROUND & INTRODUCTION
Topical film-forming solutions (FFSs) represent an innovative form of sustained release dermatological dosage forms. They can be applied to…
Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect:…
Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was…
Nagase Viita receives EcoVadis highest Platinum rating for sustainability
PRESS RELEASE
April 2, 2024
Nagase Viita Co., Ltd. (Headquarters: Kita-ku, Okayama; Representative Director: Naoki Yasuba), a member of the NAGASE Group, has received the highest "Platinum" rating in a sustainability survey conducted…
Preparation, Characterization, and Evaluation of a Novel Co-Processed Excipient as a Directly…
Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and…
Benefits of an Optimal Tabletability DC Mannitol on Compression Setting Parameters
This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
An increasing number of APIs present stability challenges and…
Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl…
ABSTRACT
The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a…
Enabling superior drug loading in lipid-based formulations with lipophilic salts for a brick dust…
Lipid-based formulations (LbFs) are an extensively used approach for oral delivery of poorly soluble drug compounds in the form of lipid suspension and lipid solution. However, the high target dose and inadequate lipid solubility limit the…
A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities
Abstract
Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction…
A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE…
Abstract
Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous…
Resomer® and Lactel® Portfolio of Excipients for Parenteral Controlled Release by Evonik
A broad, versatile range of standard, custom and specialized parenteral excipients
The RESOMER® and LACTEL® portfolios provide an industry-leading selection of functional excipients for parenteral controlled release. As an expert…
Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin:…
Abstract
Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of a drug-containing core, a swellable/biodegradable polysaccharide inner…
Preparation of antibody-loaded protein microbeads for pulmonary delivery via Shirasu porous glass…
Reversible protein precipitates (protein microbeads) have been developed using Shirasu porous glass (SPG) membrane emulsification. Microbeads have a mean size of a few micrometers (2–5 μm), and their formation is reversible upon…
Optimizing API Load and Minimizing Tablet Weight Leveraging an Innovative DC Mannitol
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Tablets with stability issues often use mannitol, a stable, water-soluble…
Excipient Reactivity and Drug Stability in Formulations
This is about the excipient used for achieving sustained release function undergone chemical reaction with the stabilizing agent used for the drug product leading to product quality failure from the desired dissolution behavior. The generic…
Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams
Recently, vast efforts towards sustainability have been made in the pharmaceutical industry. In conventional oil-in-water (O/W) cream formulations, various petroleum-based excipients, namely mineral oil and petrolatum, are commonly used.…
Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the…
Abstract
Pinosylvin monomethyl ether (PsMME) is a natural compound known for its valuable bioactive properties, including antioxidant and anti-inflammatory effects. However, PsMME’s susceptibility to photodegradation upon exposure to…
Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches…
Abstract
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised…
Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for…
In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives.…
Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal…
The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote lymphatic drug targeting for cancer therapy;…
Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the…
Abstract
Hot melt extrusion (HME) is a common manufacturing process used in the pharmaceutical industry to improve the solubility of poorly soluble active pharmaceutical ingredients (API). The goal is to create an amorphous solid…
Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies
In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the…
Innovative pharmaceutical techniques for Paediatric dosage forms: a systematic review on 3D…
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients,…
Improving Active Pharmaceutical Ingredient Formulation by Hot Melt Extrusion
This poster was presented at PBP World Meeting 2024 in Vienna:
The integration of Artificial Intelligence (AI) and big data into pharmaceutical research over the past two decades has revolutionized drug discovery, enabling the…
Rethinking the development of controlled release formulations and manufacturing processes –…
We invite you to our next webinar:
"Rethinking the development of controlled release formulations and manufacturing processes"
During this webinar we will cover the key topics related to controlled release formulations in drug…
Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of…
Abstract
The aim of this study was to determine the drug loading capacity of phosphatidylcholine-based formulations for four poorly water-soluble drug substances (clofazimine, fenofibrate, artemether, cannabidiol). Two self-dispersing…
Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate.…
Progress and Opportunities for Machine Learning in Materials and Processes of Additive Manufacturing
In recent years, there has been widespread adoption of machine learning (ML) technologies to unravel intricate relationships among diverse parameters in various additive manufacturing (AM) techniques. These ML models excel at recognizing…
Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However,…
Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet
An industrial case study of attempting to comply with EU regulation 2022/63
Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has…
The interplay of poorly soluble drugs in dissolution from amorphous solid dispersions
In recent years, the application of fixed dose combinations of antiretroviral drugs in HIV therapy has been established. Despite numerous therapeutic benefits, this approach poses several challenges for the formulation development…
The Potential for a Ban on TiO2 (E171) use in Pharmaceuticals
POTENTIAL TiO2 BAN
STATUS AND IMPLICATIONS
The EU considers banning TiO2 in pharmaceuticals, potentially impacting over 91,000 drug products and causing shortages.
Titanium dioxide, also known as E171 or TiO2, has long been used across…
Unlocking new dimensions in long-acting injectables using lipid mesophase-based beads
In this study, we explored the use of lipid mesophases (LMPs) as a biocompatible and biodegradable material for sustained drug delivery. Our hypothesis centered on leveraging the high surface-to-volume ratio of LMP-based beads to enhance…
Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations
Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain…