Abstract Summary

Two case studies were conducted to evaluate the material attributes of hypromellose (METHOCEL™ K4M premium cellulose ethers) and Starch 1500® partially pregelatinized maize starch on the performance of extended release (ER) matrices. Variations in the properties of hypromellose K4M had minimal effect on theophylline release profiles, but changes in hydroxypropyl substitution levels (% HP) and particle size of the polymer impacted the drug release from hydrochlorothiazide (HCTZ) matrix tablets. Variations in Starch 1500 properties had no significant effect on drug release regardless of drug solubility. In both case studies, coarse Starch 1500 particles resulted in slightly lower tablet strength.

Hua Deng, Lawrence Martin, Brad Prusak, Shahrzad Missaghi, Thomas P. Farrell and Ali Rajabi-Siahboomi

Colorcon – CRS 2013