Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier
Objective: In the present study an effort was initiated to prepare alginate oating microparticles for oral delivery of levofloxacin.
Methods: Alginate oating microparticles were prepared by ionotropic gelation method with calcium carbonate (CaCO ) 1% w/v in gelation medium used as gas-forming agent. Chitosan was used to improve the drug 3 encapsulation efciency. A number of physiochemical properties such as particle size, shape, in vitro buoyancy and drug releasewere comparedwith non-oatingmicroparticles.
Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier
Manoj Kumar , Rajesh Shukla , Gopal Rai 1 2 2
1SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) – 495009 India.
2 Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Kukrikheda, Barela, Jabalpur, M.P. India 483001.
1SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) – 495009 India.
2 Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Kukrikheda, Barela, Jabalpur, M.P. India 483001.