Development of gastroretentive sustained release drug delivery system for certain antibiotic and its in-vitro and in-vivo evaluation

Development and evaluation of ofloxacin floating drug delivery system.

This chapter aims to preparation and in-vitro evaluation of ofloxacin floating tablets using different hydrophilic swelling polymers to localize the dosage form in the stomach in order to achieve gastric retention, and hence increase drug stability, sustainment and patient compliance leading to better treatment outcomes.

 

Full factorial design using Design Expert® software was used to prepare different formulations where evaluation of significant factors was done by Analysis of variance (ANOVA).

A 23 full factorial model was developed to study the main effects of three factors namely: the type of polymer (X1), the concentration of polymer (X2), and the concentration of sodium bicarbonate (X3). The floating lag time, floating duration, percentage release after 8 hr, percentage released after 24 hr, and absorption half-life were chosen as dependent variables.

 

Development and evaluation of ofloxacin size increasing drug delivery system.

This chapter aims to prepare directly compressed size increasing tablet of ofloxacin by using different polymers,in order to obtain a first configuration enables oral intake and a second configuration after intake which permit gastro-retention of the dosage form and hinder its passage from the pyloric sphincter to a certain time, then evaluation of the matrices for in-vitro drug release properties. Full factorial design using Design Expert® software was used to prepare different formulations where evaluation of significant factors was done by ANOVA.

A 23 full factorial model was developed to study the main effects of three factors namely: the type of polymer (X1), the concentration of polymer (X2), and the concentration of PVP K30 (X3). The increase in tablet size at 0.5 hr (Q0.5) (Y1), The increase in tablet size at 8 hr (Q8) (Y2), percentage release after 8 hr (Q8) (Y3), percentage released after 24 hr (Q24) (Y4), and absorption half-life (t50%) (Y5) were chosen as dependent variables.

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A Thesis Presented By
Dina Essam Abo el-Eezz
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