Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams
Recently, vast efforts towards sustainability have been made in the pharmaceutical industry. In conventional oil-in-water (O/W) cream formulations, various petroleum-based excipients, namely mineral oil and petrolatum, are commonly used. Natural or synthetic excipients, derived from vegetable sources, were explored as alternatives to…
Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the…
Abstract
Pinosylvin monomethyl ether (PsMME) is a natural compound known for its valuable bioactive properties, including antioxidant and anti-inflammatory effects. However, PsMME’s susceptibility to photodegradation upon exposure to…
Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches…
Abstract
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised…
Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for…
In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives.…
Improved pharmacokinetic and lymphatic uptake of Rose Bengal after transfersome intradermal…
The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote lymphatic drug targeting for cancer therapy;…
Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the…
Abstract
Hot melt extrusion (HME) is a common manufacturing process used in the pharmaceutical industry to improve the solubility of poorly soluble active pharmaceutical ingredients (API). The goal is to create an amorphous solid…
Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies
In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the…
Innovative pharmaceutical techniques for Paediatric dosage forms: a systematic review on 3D…
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients,…
Improving Active Pharmaceutical Ingredient Formulation by Hot Melt Extrusion
This poster was presented at PBP World Meeting 2024 in Vienna:
The integration of Artificial Intelligence (AI) and big data into pharmaceutical research over the past two decades has revolutionized drug discovery, enabling the…
Rethinking the development of controlled release formulations and manufacturing processes –…
We invite you to our next webinar:
"Rethinking the development of controlled release formulations and manufacturing processes"
During this webinar we will cover the key topics related to controlled release formulations in drug…
Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of…
Abstract
The aim of this study was to determine the drug loading capacity of phosphatidylcholine-based formulations for four poorly water-soluble drug substances (clofazimine, fenofibrate, artemether, cannabidiol). Two self-dispersing…
Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate.…
Progress and Opportunities for Machine Learning in Materials and Processes of Additive Manufacturing
In recent years, there has been widespread adoption of machine learning (ML) technologies to unravel intricate relationships among diverse parameters in various additive manufacturing (AM) techniques. These ML models excel at recognizing…
Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However,…
Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet
An industrial case study of attempting to comply with EU regulation 2022/63
Recently, concerns have been raised about the safety of titanium dioxide (TiO2), a commonly used component of pharmaceutical film coatings. The European Union has…
The interplay of poorly soluble drugs in dissolution from amorphous solid dispersions
In recent years, the application of fixed dose combinations of antiretroviral drugs in HIV therapy has been established. Despite numerous therapeutic benefits, this approach poses several challenges for the formulation development…
The Potential for a Ban on TiO2 (E171) use in Pharmaceuticals
POTENTIAL TiO2 BAN
STATUS AND IMPLICATIONS
The EU considers banning TiO2 in pharmaceuticals, potentially impacting over 91,000 drug products and causing shortages.
Titanium dioxide, also known as E171 or TiO2, has long been used across…
Unlocking new dimensions in long-acting injectables using lipid mesophase-based beads
In this study, we explored the use of lipid mesophases (LMPs) as a biocompatible and biodegradable material for sustained drug delivery. Our hypothesis centered on leveraging the high surface-to-volume ratio of LMP-based beads to enhance…
Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations
Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain…
Exploring Immersion Coating as a Cost-Effective Method for Small-Scale Production of Enteric-Coated…
Abstract
The coating process for solid dosage forms is widely used in the pharmaceutical industry but presents challenges for small-scale production, needed in personalized medicine and clinical or galenic settings. This study aimed to…
In April 2024 Hayashibara became Nagase Viita
PRESS RELEASE
April, 2024
Our origins date back to when sweet foods held great value, and our company crafted syrup from starch, a natural gift from the sun in Okayama, Japan. Since then, we have been dedicated to enhancing the quality…
Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short…
The production of short chain fatty acids (SCFAs) by the colonic microbiome has numerous benefits for human health, including maintenance of epithelial barrier function, suppression of colitis, and protection against carcinogenesis. Despite…
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for…
Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytokine responsible for the activation of nuclear factor-κB pathway in atopic dermatitis. To evaluate the efficacy of…
Utilization and Evaluation of Rice Bran and Rice Bran Wax as a Tablet Lubricant
Abstract
The rice bran and rice bran wax of the KJ CMU107 rice strain were investigated as potential tablet lubricants in a directly compressed tablet formulation. Stabilized full-fatted rice bran (sFFRB), stabilized defatted rice bran…
Engineering of Highly Drug Loaded, Free-Flowing Mini-Particles via Tangential Spray Fluid Bed…
This poster was presented at the PBP World Meeting 2024 by Glatt Pharmaceutical Services with the Utrecht Institute for Pharmaceutical Sciences:
Introduction
Personalized medicine combines various approaches to establish therapy regimens…
The effect of oral trehalose on inflammatory factors, oxidative stress, nutritional and clinical…
Abstract
Background
Traumatic brain injury (TBI) is the most common cause of cognitive and behavioral deficits, disability, and mortality worldwide. Trehalose is a natural non-reducing disaccharide of glucose which its anti-inflammatory…
3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and…
Abstract
The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently,…
Transdermal Administration of Nanobody Molecules using Hydrogel-Forming Microarray Patch Technology:…
Abstract
Nanobody molecules, derived from heavy-chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single-domain format facilitates…
Pediatric Formulations Developed by Extrusion-Based 3D Printing: From Past Discoveries to Future…
Abstract
Three-dimensional printing (3DP) technology in pharmaceutical areas is leading to a significant change in controlled drug delivery and pharmaceutical product development. Pharmaceutical industries and academics are becoming…
Compaction and Structural-Mechanical Properties of Tablets as a Function of Volume Ratios of…
Introduction
Using in tablet formulations microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4 ) with brittle behaviour under compaction is very popular in the pharmaceutical industry for…
Based on Eudragit® encapsulated ionic polymer IR775@nido-carborane strategy: release, bioactivity…
To enhance the bioavailability of carborane as a potential pharmacophore for BNCT, we labeled the modified o-carborane with the near-infrared dye IR775 and encapsulated it using two types of Eudragit® (pH-sensitive and osmotic).…
Machine vision-based non-destructive dissolution prediction of meloxicam-containing tablets
Machine vision systems have emerged for quality assessment of solid dosage forms in the pharmaceutical industry. These can offer a versatile tool for continuous manufacturing while supporting the framework of process analytical technology,…
Enhancing Drug Efficacy: Gattefossé’s Expertise in Excipient Selection
About our company
The Gattefossé Group is a community of employees, all driven by a dual mission: the performance of its products and the personalized support to its customers. Gattefossé develops, manufactures and sells cosmetic…
Magnetic Lipid-Based hybrid nanosystems: A combined stimuli- responsive nanocarriers for enriched…
Magnetic Lipid-Based Hybrid Nanosystems (M-LCNPs) is a novel nanoplatform that can respond to magnetic stimulus and are designed for delivering L-carnosine (CN), a challenging dipeptide employed in the treatment of breast cancer. CN…
Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro…
Abstract
Background
Nanocrystals can be produced as a dry powder for inhalation (DPIs) to deliver high doses of drug to the lungs, owing to their high payload and stability to the shear stress of aerosolization force. Furthermore,…