Speech: Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Description

Watch Lise Vandevivere’s and Nina Hauschildt’s presentations from the ExciPerience 2021 here!

Speech 1: Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient formulation development. Therefore, the current study identified binder attributes affecting the binder effectiveness in a wet granulation process of a highly soluble model excipient (mannitol). As the impact of binder attributes on the granulation process of a poorly soluble formulation (dicalcium phosphate) was previously investigated, this enabled a comprehensive comparison between both formulations in current research focusing on binder selection.

Speech 2: Immediate release coating for improved patient acceptance at optimized process time and cost: A new ready-to-use solution

Fully formulated systems for aqueous film coating are the quickest method to enhance tablet appearance, swallowability, taste and feel of oral drug products with an immediate release profile. In this talk, Evonik will introduce a new one step ready-to-use dry powder for immediate release coatings that produces films with high glossiness at reduced processing time and cost which do not affect dissolution or disintegration profiles.

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The Exciperience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It was the intersection between all the different perspectives and people in the excipient community.