FlowLac by MEGGLE is directly compressible lactose having a spherical agglomerate shape, consisting of small alpha-lactose monohydrate crystals bound by amorphous lactose. It  is produced by spray-drying a suspension of fine milled…

This poster was presented at the ECP 2025 in Porto Introduction The following polymorphic forms of lactose exist: α-Lactose Monohydrate (α-LMH), α-Lactose Anhydrous (α-LA) stable, α-LA unstable, β-Lactose Anhydrous (ß-LA) and…

MEGGLE published a study and an update on the topic of "Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients” in 2024. Pharma Excipients interviewed Dr. Spellerberg from MEGGLE about the background and…

Lactose is recovered from whey through crystallization process, where a concentrated supersaturated solution is cooled to crystallize the lactose, leaving the impurities in the mother liquor. Designing this process requires considerations…

Hydroxypropyl methylcellulose (HPMC) is a commonly used excipient to enable controlled release (CR) performance from a hydrophilic matrix tablet. Quality-by-Design (QbD) initiatives have prompted formulators to proactively characterize and…

Abstract This study examines the influence of crospovidone (CP) manufacturer variability on the dissolution profiles of hydrochlorothiazide (HCTZ) tablets. Four CP batches from different manufacturers were characterized using pharmacopeial…

The FDA approved 50 novel drugs in 2024, marking another milestone year in pharmaceutical innovation. While various summaries have highlighted these approvals, the composition and presentation of these new drug products — encompassing APIs…

Abstract Curcumin, a bioactive compound derived from turmeric, possesses numerous pharmaceutical properties; however, its poor aqueous solubility and permeability result in low bioavailability. This study aims to develop a solid…

Abstract Mesoporous silica offers an easy way to transform liquids into solids, due to their high loading capacity for liquid or dissolved active ingredients and the resulting enhanced dissolution properties. However, the compression of…

Abstract The transient evolution of granules was studied to learn new details about the underlying mechanism for continuous wet granulation in a twin-screw extruder. Sieving and a new inline PAT for particle size development was used to…