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Here on this picture you see 

2
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<b>what happens stepwise</b>

3
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<b>so we have crystalline insoluble API.</b>

4
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<b>In the very beginning</b>

5
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<b>we have a water-soluble polymer</b>

6
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<b>and we have to bring two of those together</b>

7
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<b>in order to form an amorphous solid dispersion.</b>

8
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<b>Here for we need physical technology and</b>

9
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<b>when this is meeting liquid in the body of water</b>

10
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<b>then we get kind of a</b>

11
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<b>supersaturated solution of the API</b>

12
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<b>together with the polymer in water.</b>

13
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<b>And this would be the time where an</b>

14
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<b>insoluble drug would be made available</b>

15
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<b>for absorption into the blood.</b>