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What are the options to avoid stability issues beside protecting for moisture?

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Stability is for amorphous solid dispersions then given

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When you select the right polymer for the combination with the API

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and when you select the right quantity of polymer.

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So that's what development people have to test in the very beginning

6
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You test a number of solvents in order to see

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which one dissolves API the best. Then you test

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the number of different polymers.

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Could be something like for the renewal pyrrolidone or polyvinyl alcohol or etc.

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They also have to dissolve in the solvent and then you have to find out

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the best combinations,

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the best quality of polymer and the best quantity of polymer.

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If you have a too little quantity of polymer

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in combination with the API and the risk of recrystallization

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is much more pronounced than if you would have more of the polymer

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that would stabilize the amorphous character of the API.