Capsules are a popular dosage form in the pharmaceutical industry because they provide an easy and convenient way to administer medications, offering precise dosage control. They can be formulated to contain a variety of active ingredients, including powders, liquids, and pellets, and can also be designed for immediate or extended release. Capsules protect sensitive drugs from environmental factors like light and air, enhancing drug stability and patient adherence.
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Capsules
Characterization of enteric-coated capsules filled with colchicine loaded zein nanoparticles for…
Abstract
Aim
In this study, we developed a dual pH and time-dependent formulation for targeted colonic release, aiming at minimizing adverse effect and enhancing anticancer efficacy of colchicine in the treatment of colorectal cancer.
Article highlights
The findings of this study…
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Gastroretentive systems for prolonged release of metformin based on osmotically driven expansion
Abstract
Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral intake. Aiming to achieve a gastroretentive formulation for…
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Effects of alginate inclusion on quality attributes and storage stability of gelatin oral pellets…
Abstract
Ionic liquid (IL) salts of active pharmaceutical ingredients (API) represent promising formulations for poorly-soluble APIs as they eliminate polymorphism commonly associated with conventional API salts. Being highly viscous liquid, oral dosage formulation of API-ILs is challenging,…
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Analysis of particle motion and mixing in the powder chamber of a capsule filling machine with…
Abstract
The stirrer geometry has been experimentally shown to influence remarkably powder behaviour in the chamber of a capsule filling machine with a vacuum drum. This study investigates this influence using Discrete Element Method (DEM) simulations. First, DEM parameters of a lactose grade were…
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Application of Biomaterials in the Development of Enteric-Coated Luminar Capsule Microneedles for…
Abstract
In commercial applications, sofosbuvir (SOF) for hepatitis C is only available in tablet dosage form, resulting in minimal SOF accumulation in the liver (26.94%) due to its low intestinal permeability and high molecular weight (529.5 Da). Therefore, in this study, luminar capsule…
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Enzymatic absorption promoters for non-invasive peptide delivery
Abstract
Peptide drugs offer considerable potential for treating a diverse range of diseases. Yet, their clinical application is generally restricted to injectable therapies. The main challenge hindering their broader use through globally accessible, patient-friendly, and non-invasive delivery…
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Storage and in-use stability of an excipient enhanced growth (EEG) synthetic lung surfactant powder…
Abstract
Objective
To evaluate the storage and in-use stability of a novel synthetic lung surfactant (SLS) excipient enhanced growth (EEG) powder formulation.
Significance
Aerosol delivery of surfactant formulations could address limitations of current instilled surfactant replacement therapy…
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Sustained Release Capsules Manufacturing and Handling
Patients and caregivers experience challenges following a prescribed medicine routine. If the active pharmaceutical ingredients (API) are released quickly then patients may require multiple doses of the drug. That is to maintain treatment effectiveness. Uneven treatment and adverse effects can arise…
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Enhancing Capsule Formulations with High Bulk Density MCC: The Case of PURA Series™ Super Flow by…
In the fast-paced world of pharmaceutical manufacturing, excipients play a critical role in ensuring product quality, process efficiency, and patient compliance. One such excipient that continues to prove its value is microcrystalline cellulose (MCC)—particularly in capsule formulations. Recent…
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Tailored Biopolymer Capsules for Colon-Specific Drug Delivery: A 3D Printing Perspective
Abstract
The present study aims to develop capsules employing hot melt extrusion (HME) and fused deposition modeling (FDM) three-dimensional (3D) printing approach. The primary objective was to establish a colon drug delivery system (CDDS) based on multiple release mechanisms.
Highlights…
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