The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granules
Self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations, designed to improve the solubility of poorly-water soluble drugs. Mesoporous silica is frequently used for SMEDDS solidification by various techniques. One of them is wet granulation, which enables achieving both high SMEDDS load and good flow properties. This study…
Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or…
Abstract
Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs…
One Step In Situ Co-Crystallization of Dapsone and Polyethylene Glycols during Fluidized Bed…
Abstract
Several studies have demonstrated the feasibility of in situ co-crystallization in different pharmaceutical processes such as spray drying, hot melt extrusion, and fluidized bed granulation (FBG) to produce co-crystal-in-excipient…
Effects of wet granulation process variables on the quantitative assay model of transmission Raman…
Transmission Raman spectroscopy (TRS) is a process analytical technology tool for nondestructive analysis of drug content in tablets. Although wet granulation is the most used tablet manufacturing method, most TRS studies have focused on…
Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition…
Formation and Investigation of Cell-Derived Nanovesicles as Potential Therapeutics Against Chronic…
Abstract
This study aims to offer a new therapeutic approach using cell-derived nanovesicles (cdNVs) to overcome the lack of effective treatments for liver fibrosis, a reversible chronic liver disease. To achieve this goal we established…
Formulation of Silymarin-β Cyclodextrin-TPGS Inclusion Complex: Physicochemical Characterization,…
Abstract
Silymarin (SIL) is a poorly water-soluble flavonoid reported for different pharmacological properties. Its therapeutic applications are limited due to poor water solubility. In this study, the solubility of silymarin has been…
The effect of excipients on oral lyophilizates quality attributes
Pharmaceutical industry is constantly focused on researching patient-centered dosage forms that can maximize the therapeutic potential of an active pharmaceutical ingredient, as for example orodispersible form. The main advantage of…
Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil…
The aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in…
Formulation, characterization, pharmacokinetics and antioxidant activity of phloretin oral granules
Phloretin (PHL), a flavonoid of the dihydrogen chalcone class, is reported to have low oral bioavailability due to its poor solubility and absorption. A common approach to enhance the solubility of such flavonoids is solubilization in a…
Carboxymethyl starch films as enteric coatings: Processing and mechanistic insights
This study proposes the application of carboxymethyl starch derivatives as tablet coatings affording gastro-protection. Carboxymethyl starch (CMS) films were obtained by casting of aqueous filmogenic starch solutions with or without…
Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide…
Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of…
SPINE FIBO – Automatic Visual Inspection, Counting and Bottle Filling of Tablets &…
Highlights
• Multifunction machine for inspection, counting and bottle filling
• Exceptional 100% visual inspection of tablets, capsules & softgels
• Product sorting before final counting and filling
• Easy adjustment for bottles of…
Tableting of liquid form active ingredient with high performance liquid carrier
1. Introduction
Many liquid active ingredients are supplied in a soft-gel capsule form, because a soft gel capsule is easy to release control and can avoid formulation difficulties. However, it has serious weakness in stability, especially…
Microneedles for advanced ocular drug delivery
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, while intraocular injections are the current gold standard treatment option for treating posterior…
Stepping into small shoes: Gaining user perspective on appropriate administration devices for…
A cross sectional pan-India study about use of administration devices for paediatric oral and inhalation medicines was conducted with a diverse pool of participants of various age groups. Via 634 respondents from more than 15 states in…
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of…
Soybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid.…
A Guide to Best Practice in Sensory Analysis of Pharmaceutical Formulations
It is well established that treatment regime compliance is linked to the acceptability of a pharmaceutical formulation, and hence also to therapeutic outcomes. To that end, acceptability must be assessed during the development of all…
Development of a Carvedilol Oral Liquid Formulation for Paediatric Use
Carvedilol (CARV) is an ‘off-label’ β-blocker drug to treat cardiovascular diseases in children. Since CARV is nearly insoluble in water, only CARV solid forms are commercialized. Usually, CARV tablets are manipulated to prepare an…
Indices for the brittleness of pharmaceutical tablets: a reassessment
Brittleness is an important mechanical property. In the classical sense, a material is considered brittle if, during loading, it behaves elastically until failure. Nevertheless, it is also sometimes understood as the fact to be…
Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances,…
Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic ingredients (FCIs) of topically applied formulations or contaminants (substances) in skin…
Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for…
In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in…
Electrospun metal–organic frameworks-loaded nanofibrous carriers for drug delivery systems
Nanotechnology-based-drug-delivery processes are widely applicable for specific drug release. Various pharmaceutical carriers, such as polymeric nano-carriers (solid lipid nanoparticles, micelles, nano-gels/hydrogels, dendrimers, polymeric…
Effect of geometrical features on the capping behavior of biconvex tablets
Abstract
Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence of the geometrical features of…
A technical note: Characterization and evaluation of novel, ready to use coprocessed excipient in…
Abstract
A tablet is composed of different excipients and drug. All excipients have different properties with applications. Excipients are used to provide bulk and help to bind API into a dosage form, excipient should be inert in nature…
Drying capacity of a continuous vibrated fluid bed dryer – Statistical and mechanistic model…
The drying capacity of a continuous vibrated fluid bed dryer was studied using a DoE by varying microcrystalline cellulose content in the formulation, water amount in the twin-screw granulation, inlet air temperature, air flow rate and the…
Co-Dispersion Delivery Systems with Solubilizing Carriers Improving the Solubility and Permeability…
Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges related to their bioavailability and therapeutic efficacy upon oral…
Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System
Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as an antimicrobial delivery system is hindered by their poor stability…
3D printed pH-responsive tablets containing N-acetylglucosamine-loaded methylcellulose hydrogel for…
The pH-responsive drug release approach in combination with three-dimensional (3D) printing for colon-specific oral drug administration can address the limitations of current treatments such as orally administered solid tablets. Such…
Fast Track development of Biphasic nano-dexamethasone Pellets using galenIQ™
PharmaExcipients and Beneo proudly present the new webinar:
The low solubility of many drug active ingredients is not only challenging to formulators, but it can also mean that new effective medicines take longer to reach the market and…
Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads Using Box–Behnken Design…
Purpose
The main objective was to develop and optimize a multiparticulate system of 5-fluorouracil through the Box–Behnken design (BBD) and desirability function and coating of the optimized batch for increased therapeutic efficacy and…
HiCel™ Silicified Microcrystalline Cellulose, Versatile Excipient for Nutraceutical Herbal Tablet…
Abstract
Nutraceutical herbal medicine and supplements demand increases day by day. Herbal medicine normally contains lipids, protein, carbohydrate, vitamins, minerals and other necessary nutrients depending upon their emphases. Generally,…
Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into…
The development of wound-dressing materials has attracted significant research interests in recent years. With the advancement of nanofabrication, the application of nanoparticles (NPs) in drug delivery systems has become feasible. However,…
Drug‑Excipient Compatibility Study Through a Novel Vial‑in‑Vial Experimental Setup: A Benchmark…
Abstract
Drug-excipient compatibility study (DECS) is one of the critical steps during pre-formulation studies to select the appropriate excipient to obtain a stable formulation/dosage form. As such, there is no recommended guideline for…
Investing in automated visual inspection and sorting machines: costs, risks and performance…
Introduction
Pharmaceutical companies are increasingly investing in automated visual inspection and sorting machines in order to replace subjective and costly manual sorting. These machines need to efficiently replace human hands by…