Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures?
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic TPU ratio relative to varying ethylene vinyl…
Four Dow USA sites receive EXCiPACT GMP certification as pharmaceutical excipient suppliers
EXCiPACT asbl is pleased to announce that four Dow USA sites have each been awarded an EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies. The Certificates demonstrate that
Dow Midland…
Thermodynamic and kinetic evaluation of the impact of polymer excipients on storage stability of…
Two pharmaceutical polymers with high glass transition temperatures (Tg>100°C), polyvinylpyrrolidone-vinyl acetate copolymer (PVPVA) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), have been assessed for their impact on the…
Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical…
Physicochemical properties of peptides need to be compatible with the manufacturing process and formulation requirements to ensure developability towards the commercial drug product. This aspect is often disregarded and only evaluated late…
Freeze/thaw of IGG solutions
In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed…
Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult…
Solidification to Improve the Biopharmaceutical Performance of SEDDS: Opportunities and Challenges
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the…
Variability of Magnesium Stearate
The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical…
Overcoming Solubility Challenges: Exploring the Lipids Option
Live Multimedia PresentationThursday, December 13, 2018 at 2pm EST • 1pm CST • 11am PST
Event OverviewAs more molecules in development prove to be highly insoluble, formulators are exploring new alternatives that offer the desired…
Whey proteins as stabilizers in amorphous solid dispersions
Whey proteins are extensively used as nutritional supplements but have so far not been investigated as co-formers for amorphous solid dispersions (ASD) to enhance the solubility and dissolution rate of poorly water soluble drugs. In this…
3D printed elastic mould granulation
In the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the…
Accelerated Development – Upgrade your existing Glatt Fluid Bed Processors with PAT tools
Do you want to accelerate, improve and optimize your product development?
Are you looking for improved process understanding?
Innopharma Technology and Glatt have joined forces to offer existing users of the Glatt Lab Scale Fluid Bed…
The new USP Microcrystalline Cellullose Monograph – PDF Download available
The revision to the harmonized standard for Microcrystalline Cellullose has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 4 (former Stage 6) of the PDG process,…
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its…
3rd European Conference on Pharmaceutics
Bologna from 25 to 26 March 2019
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Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique
Abstract: Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl…
A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing
A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar,…
Dynamic Properties of Novel Excipient Suggest Mechanism for Improved Performance in Liquid…
To improve liquid formulation stability, formulators employ various excipients designed to stabilize protein drugs, including buffers, salts, sugars, and surfactants. One of the roles of surfactants is to protect the protein drug from…
Microcrystalline Cellullose – Notice of Adoption of Harmonized Standard
The revision to the harmonized standard for Microcrystalline Cellullose has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 4 (former Stage 6) of the PDG process,…
Formulation and Manufacturing of Solid Dosage Forms
As solid dosage forms remains the primary option when developing a drug product, it was felt by the guest editors that the need to have a special issue on formulation and manufacturing of solid products could not be overstated. We have seen…
Excipients in children’s medicines
This leaflet offers advice about the common ingredients used to make up children’s medicines. These ingredients are called ‘excipients'
All forms of medicine contain ingredients as well as the drug – these are called excipients.…
To use Talc or not to use Talc: Should this even be a Question?
Magnesium silicate (MgSiO3) when hydrated is most commonly known as “Talc”. In the pharmaceutical industry, talc is used primarily as a glidant to improve powder flow in tablet compression. Of course, talc is also used by the personal care…
The Coming of Age of Amorphous Solid Dispersions
Although the majority of new drug candidates suffer from poor solubility and bioavailability, oral solid dosage forms remain the preferred route of administration due to their ease of use and convenience for patients and caregivers. In…
Liquisolid Systems: Understanding the impact of drug state (solution or dispersion), nonvolatile…
The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an…
Application of design of experiment approach for investigating the effect of partially…
The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using…
Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for…
The therapeutic potential of cannabinoids has been truly constrained heretofore due to their strong psychoactive effects and their high lipophilicity. In this context, precisely due to the lack of psychoactive properties, cannabidiol (CBD),…
Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet…
The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and dilu- ent factors…
A combination of the advantages of film coating and sugar coating?
Sugar Coating – from conventional to continuously automated When it comes to aesthetics, shine and good insulation, traditional sugar-coated tablets are still a very popular dosage form. Among the numerous coating layers, the bad-tasting…
Hybrid modeling of roll compaction processes with the Styl’One Evolution
Roll compaction/dry granulation is a widely used and cost effective dry granulation method. To save time and material in formulation development, some approaches have been made to predict the most important parameters in roll compaction…
A Big Data Approach to Pharmaceutical Flow Properties
Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need…
Printfills: 3D printed systems combining Fused Deposition Modeling and Injection Volume Filling.…
Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling (FDM)…
Pharmaceutical excipients, news from China
Chinese authorities pointed out a new roadmap on the quality of pharmaceutical excipients. The representatives of the Chinese Pharmacopoeia have talk about that last September 18th, during a workshop organised by Edqm.
In the last…
A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the…
Novel cellulose-gelatin composite films made from self-dispersed microgels: Structure and properties
A series of epichlorohydrin-couple-linked cellulose-gelatin composite films (ECGF) was fabricated in NaOH/urea aqueous solution using a process involving homogenous blending, coupling, dialysis, self-dispersion, microgel solution casting,…
Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating…
The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution…