Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling
Direct compression is potentially sensitive to particle size distribution (PSD) variability in pharmaceutical grade excipients. Yet, the impact is insufficiently studied. Furthermore, the use of force sensor as a process analytical technology (PAT) platform, to monitor the effect of PSD variations on compact tensile strength, is a readily available…
Nanocarrier Vaccines for SARS-CoV-2
The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on…
What are the Ingredients and Excipients in the COVID-19 Vaccines? Update including…
AstraZeneca COVID-19 vaccine ingredients (Source Gov.UK)
One dose (0.5 ml) contains: COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 × 10^10 viral particles (vp)*Recombinant, replication-deficient chimpanzee adenovirus vector encoding the…
Using natural alternative excipients for tableting and capsule filling
A large number of dietary supplements are available in solid oral dosage forms. Vitamin and mineral supplements can be easily pressed into tablets by wet granulation or direct compression, but such tablet formulations require good binders.…
Asahi Kasei to build a second plant for Ceolus™ microcrystalline cellulose – Press Release
Asahi Kasei's Specialty Solutions SBU will build a second plant for microcrystalline cellulose (trade name Ceolus™) at its Mizushima Works in Kurashiki, Okayama, Japan.Asahi Kasei currently manufactures Ceolus™, a microcrystalline…
Cilostazol Solubilization and Stabilization Using a Polymer-Free Solid Dispersion System
The development of pH-independent drugs is difficult because it involves improvements in their solubility and dissolution (%) in solubilizer. In the present study, the pH-independent cilostazol (CLT) was formulated for enhanced solubility…
Development of novel darunavir amorphous solid dispersions with mesoporous carriers
The aim of this work was to compare mesoporous carriers based on silica and magnesium aluminosilicate in the amorphous solid dispersion production. Darunavir has been selected as an active pharmaceutical ingredient that is classified as a…
Advancing the Science of TUPs Management: Improved Process Controls, Enhanced Testing Methods and…
Off colored particles, also known as technically unavoidable particles (TUPs) or black specks, have presented challenges for pharmaceutical customers and excipient suppliers for decades. An inherent variability of standard testing and the…
Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a…
Thermal Stability of Amorphous Solid Dispersions
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs. One of the major keys for successful preparation of ASD is the…
3D–Printed Zero-Order Released Platform: a Novel Method of Personalized Dosage Form Design and…
In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and development of hypoglycemic drugs has become a top priority. Among them, sulfonylurea…
Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies
Multiple considerations are essential to address the main challenges of dose flexibility and patient adherence in pediatric drug development, particularly for oncology. Mini-tablets, 2 mm in diameter, were manufactured using a rotary tablet…
Best Practices for Selection of Excipients for Paediatrics – Workshop Reflection
The development of age appropriate formulations for the paediatric population has become one of the key areas of focus for the pharmaceutical industry – with a subsequent influence on excipient use. Selection of excipients with appropriate…
Co-processing of small molecule excipients with polymers to improve functionality
Introduction
Polymers have various applications such as binder, film coating agent, stabilizer, drug release modification and as primary packaging materials. Recently, they have been explored in co-processing technique to improve the…
Development and statistical optimization of alginate-Neusilin US2 micro-composite beads to elicit…
The Alginate-Neusilin US2 micro-composite (MC) beads were fabricated and optimized for oral delivery of hesperidin (HES). A 32 full factorial design encompassing independent variables (factors) such as the concentration of sodium alginate…
mRNA vaccines — a new era in vaccinology
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has…
Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Formulations
Polyvinylpyrrolidone (PVP), a non-ionic polymer, has been employed in multifarious fields such as paper, fibers and textiles, ceramics, and pharmaceutics due to its superior properties. Especially in pharmacy, the properties of inertness,…
Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment…
The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral bioavailability of CBD is low owing to its high lipophilicity and extensive…
Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids
Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using…
Oral drug delivery systems using core–shell structure additive manufacturing technologies: a…
The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core–shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal…
Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid…
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the…
High-Payload chitosan microparticles for the colonic delivery of quercetin: Development and in-vivo…
Quercetin, a natural flavonoid has high potential for management of inflammatory bowel diseases (IBD). However, its onset of action is delayed when administered systemically and high doses are needed for IBD treatment. The present study…
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption…
Starch Products as Candidate Excipients in a Continuous Direct Compression Line
Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder…
Stability properties and antioxidant activity of curcumin nanosuspensions in emulsion systems
In this study, curcumin nanosuspensions (Cur-NSs) were prepared using D-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS), and their physical properties (i.e., particle size, dispersion stability) were investigated. Also, the…
A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets
There is a clear need for a robust process analytical technology tool that can be used for on-line/in-line prediction of dissolution and disintegration characteristics of pharmaceutical tablets during manufacture. Tablet porosity is a…
Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug…
Numerous diseases have been reported to affect the lymphatic system. As such, several strategies have been developed to deliver chemotherapeutics to this specific network of tissues and associated organs. Nanotechnology has been exploited…
Enteric Hard Capsules for Targeting the Small Intestine: Positive Correlation between In Vitro…
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were…
Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of…
Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared…
Pharmatrans SANAQ® SL 004 co-processed Starch/Lactose excipient
Pharmatrans Sanaq now offers SANAQ® SL 004 as a co-processed excipient based on mix 15/85 of maize starch and lactose monohydrate.SL 004 forms an ultra-uniform and highly compressible lactose excipient for tablet fillings that supports…
Lipid-based formulations: winning strategy for oral bioavailability enhancement
Many drugs exhibit poor solubility and/or permeability leading to weak oral bioavailability. To overcome these issues different technologies have been developed. Among them, lipid-based formulation (LBF) is a worth-considering option as it…
Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal…
Fungal infection of the skin is one of the most common dermatological diseases in the world. Gel formulations are among the most suitable dosage forms for topical use to treat cutaneous infection. Nanotechnology is a promising approach to…
DRcaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical…
Probiotics and enzymes are sensitive to acid and run the risk of being rendered less effective while crossing the low pH of the stomach on their way to the intestinal tract. That is why, Capsugel® performed a gamma-scintigraphy study that…
Nanostructured lipid carriers as a strategy for encapsulation of active plant constituents:…
Active plant constituents obtained from edible sources have manifested their pharmacological potential as a therapy against several diseases. But the lack of their desired physicochemical properties such as solubility, permeability…
Biopolymer Coatings for Biomedical Applications
Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and…