Pharma Excipients

News on Pharma Excipients

Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures?

Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic TPU ratio relative to varying ethylene vinyl…

Freeze/thaw of IGG solutions

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed…

Variability of Magnesium Stearate

The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical…

3D printed elastic mould granulation

In the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the…

Formulation and Manufacturing of Solid Dosage Forms

As solid dosage forms remains the primary option when developing a drug product, it was felt by the guest editors that the need to have a special issue on formulation and manufacturing of solid products could not be overstated. We have seen…

Excipients in children’s medicines

This leaflet offers advice about the common ingredients used to make up children’s medicines. These ingredients are called ‘excipients' All forms of medicine contain ingredients as well as the drug – these are called excipients.…

The Coming of Age of Amorphous Solid Dispersions

Although the majority of new drug candidates suffer from poor solubility and bioavailability, oral solid dosage forms remain the preferred route of administration due to their ease of use and convenience for patients and caregivers. In…

Pharmaceutical excipients, news from China

Chinese authorities pointed out a new roadmap on the  quality of pharmaceutical excipients. The representatives of the Chinese Pharmacopoeia have talk about that last September 18th, during a workshop organised by Edqm. In the last…