Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone substitute
Abstract
Objectives
This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL Bone.
Methods
Twelve participants requiring…
Advancing oral delivery of biologics: Machine learning predicts peptide stability in the…
The oral delivery of peptide therapeutics could facilitate precision treatment of numerous gastrointestinal (GI) and systemic diseases with simple administration for patients. However, the vast majority of licensed peptide drugs are…
Application of NMP and Neusilin US2-integrated liquisolid technique in mini-tablets for improving…
Frankincense and myrrh are widely used Chinese medicines, showing clinically relevant synergistic therapeutic effects in the treatment of inflammation and cancer. We investigated the applicability of a liquisolid (LS) technique to the…
3D printed multi-drug-loaded suppositories for acute severe ulcerative colitis
Acute severe ulcerative colitis (ASUC) is a growing health burden that often requires treatment with multiple therapeutic agents. As inflammation is localised in the rectum and colon, local drug delivery using suppositories could improve…
FDA Concludes that Existing Regulatory Frameworks for Foods and Supplements are Not Appropriate for…
Given the growing cannabidiol (CBD) products market, the U.S. Food and Drug Administration convened a high-level internal working group to explore potential regulatory pathways for CBD products. Today we are announcing that after careful…
Use of polyvinyl alcohol (PVA) to overcome challenges in ophthalmic formulations
Successful ophthalmic drug formulations rely on the selection of the correct polymer to ensure the desired characteristics such as retention in the eye cavity and solubility. One example of such an excipient is polyvinyl alcohol (PVA) which…
Drug delivery as a sustainable avenue to future therapies
Climate change and the need for sustainable, technological developments are the greatest challenges facing humanity in the coming decades. To address these issues, in 2015 the United Nations have established 17 Sustainable Development…
Stability of APIs in Super Refined PEG – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Polyethylene glycols (PEGs) are excipients that are widely used in oral, parenteral and topical delivery dosage forms. Low molecular weight PEGs, such as PEG 300 and PEG 400 in…
Unveiling the dielectric properties of self-nanoemulsifying drug delivery systems (SNEDDS)
Self-nanoemulsifying Drug Delivery System (SNEDDS) improves the bioavailability of bioactive compounds that exhibit low water solubility. In this regard, our study aims to assess the formulation of SNEDDS in a wide range of oil…
The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various…
Nanosized Drug Delivery Systems to Fight Tuberculosis
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing antitubercular therapies are long, complex, and have severe side effects that result in low patient compliance. In this context, nanosized drug delivery…
Paediatric Solid Oral Dosage Forms for Combination Products: Improving In Vitro Swallowability of…
There is a growing interest in determining and improving the acceptability of solid oral dosage forms (SODF) in paediatric populations. Combination products can be an interesting solution to combine two active pharmaceutical ingredients.…
CELPHERE – Microcrystalline Cellulose seed core
Are you developing MUPS? Difficulties with crushing pellets? Pellet aggregation?
Asahi Kasei is the leading manufacturer and supplier of functional excipients such as microcrystalline cellulose (MCC) in Japan. Read more about the…
Advanced image analytics to study powder mixing in a novel laboratory scale agitated filter dryer
Powder mixing unit operations are essential to the manufacturing of pharmaceutical drug substance and drug products. To model powder mixing, computational approaches have been used to evaluate mixing indices for different types of mixers,…
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability:…
Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited…
Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and…
Design And Characterization Of Barberine Liquisolid Compacts For Escalating Bioavailability And…
The current investigation aimed to develop a barberine (BRN) loaded liquidsolid compact (SLC) to improve the oral therapeutic effectiveness of BRN. full factorial design was employed and the effect of the carrier:coating ratio (X1) and…
Design, development and evaluation of self-microemulsifying drug delivery system of pazopanib for…
Pazopanib is the first-line treatment for patients with advanced or metastatic renal cell carcinoma. However, the commercially available preparation is characterized by low solubility, poor bioavailability and suboptimal therapeutic…
Pullulan in pharmaceutical and cosmeceutical formulations: A review
Pullulan, an α-glucan polysaccharide, is colorless, odorless, non-toxic, non-carcinogenic, highly biocompatible, edible and biodegradable in nature. The long chains of glucopyranose rings in pullulan structure are linked together by α-(1 → …
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion…
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients…
Nitrosamine Risk Assessments in Oligonucleotides
The European Medicines Agency, the U.S. Food and Drug Administration, and other regulatory agencies expect that all pharmaceutical products be assessed for the potential presence of N-nitrosoamine (nitrosamine) impurities. This white paper…
Surface Modification of Lactose Carrier Particles Using a Fluid Bed Coater to Improve Fine Particle…
Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces and evaluate…
Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products…
Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been…
Optimising nasal powder drug delivery – Characterisation of the effect of excipients on drug…
The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional…
Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen…
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal…
Cationic Solid SMEDDS of Efavirenz for Improved Oral Delivery: Development by Central Composite…
Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design were…
Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet…
As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have…
3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients
Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets…
Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against…
Excessive acetaminophen (APAP) induces excess reactive oxygen species (ROS), leading to liver damage. Pterostilbene (PTE) has excellent antioxidant and anti-inflammatory activities, but poor solubility limits its biological activity. In…
Formulation, development and characterization of ibuprofen microemulgel for arthritis
Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral…
who advances drug delivery? we do. – pharmaceutical product and solution guide by Ashland
advancing drug delivery
Ashland’s pharmaceutical team prides itself on advancing drug delivery with sophisticated science-based solutions. Our global centers of excellence contain the latest equipment and our research scientists and…
Avoiding N-nitrosodimethylamine formation in metformin pharmaceuticals by limiting dimethylamine and…
Since late 2019, concerns regarding trace levels of the probable human carcinogen N-dimethylnitrosamine (NDMA) in Metformin-containing pharmaceuticals have been an issue if they exceeded the maximum allowable intake of 96 ng/day for a…
3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma
Abstract
Objectives
To develop a sustained release 5-fluorouracil (5-FU) implant by three-dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery.
Methods
3D-printed implants…
Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends on the…
Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease…