Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating process
Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT images of several commercially-available film-coated…
Introduction to pharmaceutical excipients – a video
In this video Chris Moreton gives an interesting insight on pharmaceutical excipients.
Considering 3D Printing for Solid Dosage Forms
Three-dimensional printing (3DP) is also known as additive manufacturing because these technologies create a part by adding material layer by layer, guided by a 3D computer model. Various types of 3DP are being used in manufacturing in…
2019 IPEC Europe Annual Excipients Forum
Thursday 31 January 2019
The Westin Dragonara, St Julian's, Malta
The theme of the 2019 Forum is "Excipient Integrity". The programme will cover many ‘hot’ topics including best practices and insights that can help your company adapt…
Just a spoonful of… makes the medicine go down.
galenIQ™ is a soluble filler-binder characterized by its ease of use and applicability to a wide range of solid and liquid medicine such as tablets, sachets, lozenges and syrups. The main reason it works is its delicate sweetness. Read more…
Rheology of Cellulose Ether Excipients Designed for Hot Melt Extrusion
new family of cellulosic ether polymeric excipients has been recently engineered for fabrication of amorphous solid dispersions (ASDs) of active pharmaceutical ingredients (API) via hot-melt extrusion (HME). These hydroxypropyl methyl…
22nd Microencapsulation Industrial Convention
The Bioencapsulation Research Group organizes the 22nd Microencapsulation Industrial Convention
June 3-6, 2019 in Zurich, Switzerland
13 Presentations from experts
Lectures from leading experts will cover a large scope of the…
Dissolution improvement of an active pharmaceutical ingredient in a polymer melt by hot melt…
Dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in polymeric melts plays an important role in the manufacturing of solid dispersions and solid solutions. The understanding of the dissolution is essential for…
FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with…
A compatibility study of drug substance with excipients is a crucial step in the drug development process in order to generate potent final drug formulations for efficient and safe therapy for various diseases. Thus, the development of new…
The Importance of Excipient Composition and Complexity
Tuesday, November 13, 2018 - 11:00am
This webinar presented by Chris Moreton and Brian Carlin will provide an overview of excipient composition and complexity. In this Quality by Design age and the need for enhanced understanding,…
Oxygen sensitive nanoparticles used for 3D printing of complex tissue-like structures
Researchers have implemented oxygen sensitive nanoparticles into a gel material that can be used for 3D printing of complex, biofilm and tissue-like structures…
An international team of researchers have implemented oxygen sensitive…
SeDeM expert system for directly compressed tablet formulation: A review and new perspectives
The pharmaceutical tablet formulation design is a risky and challenging process since it largely depends on experience. The fundamental reasons lie in the lack of understanding of powder properties and the interactions between the active…
Quality Deviation Handling on the Polymeric Coating of Pharmaceutical Tablets
This work aimed to map and discuss tablet-coating choice, quality deviations of this process, and corrective actions taken by Research and Development (R&D) teams from pharmaceutical industries.
Methods
A cross-sectional study of…
A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the…
Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography
The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was…
Lecithin–chitosan–TPGS nanoparticles as nanocarriers of (−)-epicatechin enhanced its anticancer…
Natural compounds such as (−)-epicatechin show a variety of biological properties including anticancer activity. Nonetheless, (−)-epicatechin's therapeutic application is limited due to its low water solubility and sensitivity to oxygen and…
EXCIPIENT AND PROCESS SELECTION FOR EXTRUSION TECHNOLOGIES
Webinar October 25, 2018 by by The Southern California Pharmaceutical Discussion Group (SCPDG) of AAPS
Registration: Please register by Monday, October 22, 2018 using link below:
SCPDG - Rational Excipient Selection and Incorporation of…
The rise of independent excipients
The pressure to innovate faster than their competitors has drug formulators exploring new ways to optimise manufacturing processes
Article in manufacturingchemist.com
Continuous manufacturing, for example, has evolved at a relatively fast…
Soluplus solutions as thermothickening materials for topical drug delivery.
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have…
Review Oral Modied Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and…
Oral modied-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated…
Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review
Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged…
Physical and rheological properties of xanthan gum agglomerated in fluidized bed: Effect of HPMC as…
Physical and rheological properties of agglomerated xanthan gum (XG), commonly used as a food thickener for the management of the patients with dysphagia (swallowing difficulty), were investigated at different concentrations (0, 2, 4, and…
FORMULATION OF SNAIL SLIME (Achatina fulica) ANTI-ACNE EMULGEL USING TWEEN 80-SPAN 80 AS EMULSIFYING…
ABSTRACT
Acne is the condition of abnormal skin which is indicated by inflammation cause by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus…
Impact of capsule type on aerodynamic performance of inhalation products: a case study using a…
The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the…
Roller compaction: Improving the homogeneity of ribbon properties along the roller width
A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The…
Analysis of the powder behavior and the residence time distribution within a production scale rotary…
This study focuses on the behavior of powder particles in a rotary tablet press with special focus on the feed frame system. To obtain a better knowledge of the continuous manufacturing of tablets, the experimental setup was carried out…
Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution…
We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ), a poorly soluble drug, and its dissolution from spray-dried suspensions. To this end, ITZ suspensions…
Dropwise Additive Manufacturing of Pharmaceutical Products using Particle Suspensions
The principal method of drug delivery is by oral solid doses, the production of which often necessitates multiple post-crystallization unit operations to ensure content uniformity and/or enhance bioavailability. As an alternative to…
Evaluation of the application of cashew gum as an excipient to produce tablets
Cashew gum is extracted from the exudate of the giant cashew tree (Anacardium occidentale L.). The objective of this work was to study the extraction and purification of cashew gum through experiments to characterize its structures and…
Methodology to estimate the break force of pharmaceutical tablets with curved faces under…
This paper develops a methodology to estimate the break force of curved faced tablets under diametrical compression. Common excipients used in pharmaceutical tablet formulations, including microcrystalline cellulose, calcium phosphate and…
Pollen grains as a novel microcarrier for oral delivery of proteins
Oral delivery of proteins and peptides is a challenge due to their degradation in the stomach. To overcome this challenge, ragweed (Ambrosia elatior) pollen grains were engineered to serve as protective microcapsules. A matrix comprising of…
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules.…
Towards a better understanding of dry binder functionality
It is of great importance to get a deeper understanding of the binding behaviour and functionality of different types of dry binders, since dry binders are crucial to ensure appropriate properties of dry granules and tablets. Based on…
Pharmaceutical applications of spouted beds: A review on solid dosage forms
Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing…
Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate…
Co‐encapsulation of abiraterone acetate (AbrA) and docetaxel (Dtx) in polymeric nanoparticles as novel prototypes for prostate cancer treatment combining hormonal and chemotherapy was designed. Nanoparticles (NPs) composed of…