Pharma Excipients

News on Pharma Excipients

Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance

Purpose Traditionally, α-lactose monohydrate is the carrier of choice in dry powder inhaler (DPI) formulations. Nonetheless, other sugars, such as D-mannitol, have emerged as potential alternatives. Herein, we explored different particle engineering processes to produce D-mannitol carriers for inhaled delivery. Methods Wet-sieving and…

Exploring the Myth of Inert Excipients

Introduction Stable active pharmaceutical ingredients (APIs) represent a critical success factor for drug formulation for four main reasons. Firstly, the potential instability of APIs can represent a critical threat to patient safety.…

Solid lipid nanoparticles for hydrophilic drugs

Hydrophilic drugs are proficient therapeutic agents however, delivery of these drugs is a difficult task. Hence, developing an efficient drug delivery system may require a multipronged approach. Colloidal drug delivery systems such as…

Phase behavior of ASDs based on hydroxypropyl cellulose

Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates. Besides established polymer candidates, hydroxypropyl…

Emulsification Speed of Amphiphilic Starches

Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications. Typical applications are the encapsulation of lipophilic compounds such as vitamins and other micronutrients or…