Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances
Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the continuous phase, limonene as the dispersed phase and a mixture of pharmaceutically acceptable surfactants…
Biodegradable polymeric nanocarriers for oral delivery of antiretroviral drug: Pharmacokinetic and…
The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability. NPs were formulated by employing D-α Tocopherol Polyethylene Glycol Succinate 1,000 (TPGS) as…
Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?
In this study, powder flowability is assessed during granular compaction under free surface conditions by using Hausner ratio (HR) as flowability index. Different kinds of pharmaceutical and food powders were examined. The assessment of the…
Designing cellulose hydrogels from non-woody biomass
Hydrogels are an attractive system for a myriad of applications. While most hydrogels are usually formed from synthetic materials, lignocellulosic biomass appears as a sustainable alternative for hydrogel development. The valorization of…
Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for…
The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and…
Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population.…
Nanocomposite sponges for enhancing intestinal residence time following oral administration
In this work, nanocomposites that combine mucopenetrating and mucoadhesive properties in a single system are proposed as innovative strategy to increase drug residence time in the intestine following oral administration. To this aim, novel…
World Malaria Day
World Malaria Day, marked each year on 25 April, is an occasion to highlight the global efforts to end malaria and the need for sustained political commitment and continued investment for malaria control and elimination. This year, the…
Nanostructured lipid carriers for enhanced in vitro and in vivo schistosomicidal activity of…
WHO considers praziquantel (PZQ) as the drug of choice for treatment of Schistosoma mansoni infection but this requires high dose due to poor solubility and first pass metabolism. The aim of this work was to optimize nanostructured lipid…
Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and…
Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic…
Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great…
Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers. Among the applications of nanocarriers, drug delivery to the skin has attracted…
Formulation and process strategies to minimize coat damage for compaction of coated pellets in a…
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage…
Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic…
Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of…
Polymeric Drug Delivery Systems by Additive Manufacturing
Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition,…
The evolution of commercial drug delivery technologies
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient…
Smart excipient improves powder flow for sachet-based products
BENEO presents galenIQ™ 721 for highly flowable and stable sachet powders
Mannheim (Germany), April 2021 – Sachets are a popular pharmaceutical and nutraceutical packaging format for consumers and manufacturers alike. To ensure accurate…
How Cellets’ particle size influences the flow behavior in a Wurster fluid-bed coater
Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…
Synergistic application of twin-screw granulation and selective laser sintering 3D printing for the…
This study demonstrated the first case of combining a novel continuous granulation technique with powder-bed fusion-based selective laser sintering (SLS) process to enhance the dissolution rate and physical properties of a poorly…
Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine
On the first day of the UK vaccination campaign with the coronavirus disease 2019 (COVID‐19) vaccine, there were reports of 2 cases of anaphylaxis within minutes of administration of the Pfizer/BioNTech messenger RNA (mRNA) vaccine and a…
Effects of Concentrating Cannabinoid Loaded Liposome Formulations
Introduction
Phytocannabinoids are chemical compounds found in the cannabis plant which have been increasingly used as therapeutics in recent years . They have shown to aid in chronic pain management for several diseases such as…
Drug solubilization during simulated pediatric gastro-intestinal digestion
To increase the understanding of how drugs behave following oral administration to the pediatric population, the aim of the present study was to investigate the solubilization of fluconazole and ibuprofen during simulated gastro-intestinal…
Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful…
Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively…
Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid…
The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid…
World Immunization Week 2021
World Immunization Week – celebrated every year in the last week of April – aims to promote the use of vaccines to protect people of all ages against disease. Immunization saves millions of lives every year and is widely recognized as one…
Coating characterization by hyperspectroscopy and predictive dissolution models of tablets coated…
The objective of current research was to develop the models of dissolution prediction of tablets coated with cellulose acetate (CA 320S or CA 398-10) and cellulose acetate phthalate (C-A-P) blends. Independent variables selected were…
Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug. Methods: The nateglinide SD prepared using crospovidone and…
Removal of azithromycin from aqueous bulk solution using water/ethanol/transcutol/capryol-90 green…
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion. The drug is identified as potential pharmaceutical drug for detrimental effect on flora and…
Formulate and Evaluate Famciclovir Floating Tablets
Floating drug delivery system of famciclovir was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability by using different polymers like HPMC E15, Xanthan gum, methyl cellulose and compritol 888…
Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different…
Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia…
Effects of monoclonal antibody concentration and type of bulking agent on critical quality…
Biopharmaceuticals represent one of the fastest growing areas in the pharmaceutical industry. Previously, protein formulations for intravenous applications were most widespread, while now the subcutaneous route of administration is gaining…
Polymeric Nanoreactors as Emerging Nanoplatforms for Cancer Precise Nanomedicine
How to precisely detect and effectively cure cancer which is defined as precise nanomedicine has drawn great attention worldwide. Polymeric nanoreactors which can in situ catalyze inert species into activated ones, can greatly increase…
Application of Modified SeDeM Expert Diagram System for Selection of Direct Compression Excipient…
In the present investigations, the SeDeM expert diagram system, modified to include two important compression properties, i.e. mean yield pressure, Py, and compactibility parameter, σtmax, was used to identify a diluent most suitable for…
Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic…
Current treatment for autonomic dysreflexia (AD) involves rupturing a liquid-filled soft capsule of nifedipine to aid rapid drug release and absorption, however, this application is not covered under the manufacturer's license. The…
Ocular Implants for Drug Delivery: Improving Patient Outcomes
Did you know that there are already 11 ocular implants on the market and over 30 in development? (See Table 1 and Figure 2). Every year, more and more people live with eye disease or vision impairment of some kind, requiring treatment to…