Performance comparison of PLA- and PLGA-coated porous bioceramic scaffolds: Mechanical, biodegradability, bioactivity, delivery and biocompatibility assessments
Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are a principal group of biomaterials employed for the regeneration of damaged tissues and therapeutic delivery. The development of ceramic tissue engineering scaffolds with an appropriate combination of mechanical and biological properties is still one of…
Recent advancements in polymeric nanofibers for ophthalmic drug delivery and ophthalmic tissue…
Nanofibers due to their unique properties such as high surface-to-volume ratio, porous structure, mechanical strength, flexibility and their resemblance to the extracellular matrix, have been researched extensively in the field of ocular…
Surface modified Genistein phytosome for Breast Cancer Treatment: In-vitro Appraisal,…
Based on phytosomes advantages over liposomes, hyaluronic acid (HA) with/out pegylated phospholipid was used to develop surface-modified genistein (Gen) phytosome as Gen pegylated hyaluophytosomes (G-PHA) and Gen hyaluophytosomes (G-HA)…
Mannitol as an Excipient for Lyophilized Injectable Formulations
The review summarizes the current state of knowledge of mannitol as an excipient in lyophilized injectable small and large molecule formulations. When compared with glycine, the physicochemical properties of mannitol make it a desirable and…
Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery…
Diosmin is a flavonoid with a great variety of biological activities including antioxidant and anti-inflammatory ones. Its cytoprotective effect in retinal pigment epithelium cells under high glucose conditions makes it a potential support…
Soluplus®-based dissolving microarray patches loaded with colchicine: towards a minimally invasive…
Considered as one of the most common inflammatory arthritis, gout is characterised by a sudden onset of severe joint pain. As the first-line drug of choice used in treating acute gout, colchicine (CLC) is hindered by poor gastrointestinal…
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently undruggable targets which could potentially be treated with RNA therapeutics. Hence, local, pulmonary delivery of RNA nanoparticles could…
Semisolid Wet Sol–Gel Silica/Hydroxypropyl Methyl Cellulose Formulation for Slow Release of Serpin…
Foot ulcerations are a disabling complication of diabetes and no treatment is currently available based on disease mechanisms. The protein serpin B3 (SB3) was identified as a positive biomarker of successful diabetic wound healing;…
Development and characterization of itraconazole non-aqueous creams for the treatment of topical…
Itraconazole is a broad-spectrum triazole antifungal agent used to prevent and treat fungal infections. Itraconazole is commercially available as an oral and intravenous formulation; however, its administration via these routes is…
Negative porosity issue in the Heckel analysis: A possible solution
A parameterization of compaction simulator generated dynamic compression profile with a few grams of powder provides important information about the material deformation and compact elasticity. The Heckel equation is by far the most popular…
Lipid-based nanocarriers for ocular drug delivery: An updated review
Recent years have witnessed a boom in ocular nanomedicine research with a number of lipid-based nanocarriers such as liposomes, niosomes, cubosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, etc., to improve…
FlowLac® – MEGGLE’s spray-dried lactose grades for direct compression
FlowLac by MEGGLE is directly compressible lactose having a spherical agglomerate shape, consisting of small alpha-lactose monohydrate crystals bound by amorphous lactose. It is produced by spray-drying a suspension of fine milled…
Continuous integrated production of glucose granules with enhanced flowability and tabletability
Glucose is widely used in both the food and pharmaceutical industry. However, the application of industrially crystallized glucose in solid dosage forms is challenged by its poor flowability and tabletability. To improve these…
Formulation and Development of Paediatric Orally Disintegrating Carbamazepine Tablets
Carbamazepine is a medicine used to manage epilepsy and partial or tonic-clonic seizures. This study aimed at formulating and obtaining carbamazepine orodispersible tablets for paediatric use at a 50 mg dose, with a diameter not greater…
Atomic Layer Coating to Inhibit Surface Crystallization of Amorphous Pharmaceutical Powders
Preventing crystallization is a primary concern when developing amorphous drug formulations. Recently, atomic layer coatings (ALCs) of aluminum oxide demonstrated crystallization inhibition of high drug loading amorphous solid dispersions…
DiCom SANAQ® SP204 – Co-processed excipient suitable for acid sensitive API’s
PHARMATRANS SANAQ offers excipients and active ingredients of outstanding quality and performance. With our research & development skill and tradition, we commit to study innovative technological solutions providing excipients…
Technology development to evaluate the effectiveness of viscosity reducing excipients
Addition of pharmaceutical excipients is a commonly used approach to decrease the viscosity of highly concentrated protein formulations, which otherwise could not be subcutaneously injected or processed. The variety of protein–protein…
Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite…
Bacteroides fragilis is one of the most common causative group of microorganisms that is associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of choice used in the treatment of SSTI caused by the…
Fabrication of Mucoadhesive Films Containing Pharmaceutical Ionic Liquid and Eudragit Polymer Using…
Oral mucositis in the oral cavity, caused by radiation therapy and chemotherapy, requires personalized care and therapy due to variations in the lesions of patients. In the present study, we fabricated a model of personalized oral film…
Vitamin E TPGS-Poloxamer Nanoparticles Entrapping a Novel PI3Kα Inhibitor Potentiate Its Activity…
N-(2-fluorphenyl)-6-chloro-4-hydroxy-2-quinolone-3-carboxamide (R19) is a newly synthesized phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitor with promising activity against cancer cells. The purpose of this study was to develop a…
Hayashibara Trehalose SG – For Antibody Purification Use brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative…
Topically applied lipid-containing emulsions based on PEGylated emulsifiers: Formulation,…
PEGylated emulsifiers have been largely used in topical formulations for skin research. They have been a continuous study focus in our group as well. According to our previous studies, severe interruptions of the skin barrier were observed…
Modeling of inter-tablet coating uniformity of electrostatic dry powder coating by discrete element…
The current study aims to apply an innovative mathematical model based on the discrete element method to numerically simulate the electrostatic dry powder coating process and to predict the inter-tablet coating uniformity. The newly…
Levofloxacin in nanostructured lipid carriers: Preformulation and critical process parameters for a…
The first step of a successful nanoformulation development is preformulation studies, in which the best excipients, drug-excipient compatibility and interactions can be identified. During the formulation, the critical process parameters and…
Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the…
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease…
Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulcerative Colitis via…
Background: Various potential effect of drugs on alleviating diseases by regulating intestinal microbiome as well as the pharmaceutical excipients on gut microbiota has been revealed. However, the interaction between them is rarely…
The emerging role of 3D-printing in ocular drug delivery: Challenges, current status, and future…
The era of the 3D printing technique emerged in 1986. With the advancement of technology, 3D printing analysis has gained massive attention and become widely used in recent years. Modern medicine has needed new advancements to provide the…
An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy
Encompassing a group of complex and heterogeneous diseases, cancer continues to be a challenge for patients and healthcare systems worldwide. Thus, it is of vital importance to develop advanced treatment strategies that could reduce the…
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and…
Objective
The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect of the roll compaction pressure on the properties of granules and high-drug-loaded (80%, w/w)…
Poloxamer: a simple and powerful solution for accelerating dissolution
Oral administration is the most commonly employed route for drug delivery. It is cost-effective and convenient for the patient, leading to high patient compliance. In order for the API to exert a physiological effect it must pass from the…
Research of the selection of a gelling agent with further saturation of wipes with active prolonged…
Introduction
During our research of the selection of gelling agents followed by saturation of wipes with an active prolonged effect, many factors should be considered. This fact may influence further drug development. The most important…
Mathematical modeling of coating time in dry particulate coating using mild vibration field with…
To theoretically understand the previously reported dry particulate coating process using a mild vibration field with a bead media, a mathematical analysis model of the dry coating system was developed. In this coating process, an ordered…
Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug…
Objectives: To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying drug delivery system (SNEDDS).
Methods: Initially, the solubility of the EZE was determined in…
In-situ tear fluid dissolving nanofibers enable prolonged viscosity-enhanced dual drug delivery to…
Liquid and semi-solid formulations are the most commonly used drug delivery systems for ophthalmic diseases. Upon application into the conjunctival sac, these systems introduce a variable and unphysiologically high liquid volume to the eye,…
Design and evaluation of glimepiride hydrogel for transdermal delivery
The solubility of glimepiride (GM) was improved from 1.6 μg/mL to 22.0 mg/mL when GM and meglumine (MU) complexes were prepared. Therefore, transdermal hydrogels of GM Carbopol (GM-CP) and GM hydroxypropyl methylcellulose pullulan…