A Method for the Colorimetric Quantification of Sodium Lauryl Sulphate in Tablets: A Proof of Concept
Abstract
The deformulation stage of original drug products, which includes the quantification of critical excipients, is crucial for the successful development of generic drug products of solid dosage form. Sodium lauryl sulphate (SLS) belongs to the group of critical excipients due to its influence on the bioavailability of drugs, such as…
Development of mucoadhesive 3D-printed Carbopol/Eudragit/SNAC tablets for the oral delivery of…
Abstract
3D-printed dosage forms comprised of Carbopol and Eudragit were fabricated through semi-solid extrusion, combining Enoxaparin (Enox) and the permeation enhancer SNAC in a single-step process without subsequent post-processing.…
Thermally-Induced Supersaturation Approach for Optimizing Drug Loading and Biopharmaceutical…
Lipid-based formulations (LbFs) have demonstrated success in pharmaceutical applications; however, challenges persist in dissolving entire doses of the drug into defined liquid volumes. In this study, the temperature-induced supersaturation…
Improvement of Bioavailability of Sildenafil Citrate Through Taste Masked Orodispersible Film for…
The oral bioavailability of sildenafil citrate is approximately 43%, primarily limited by the low aqueous solubility and first-pass effect. Considering the drug properties and biopharmaceutical considerations, this study aimed to develop an…
Functional Materials from Lipids and Proteins
See the new book, edited by Nandika Bandara and Aman Ullah. This book provides an international viewpoint on recent developments in the utilisation of lipids and proteins together.
Description: In recent years, the use of renewable raw…
Dual-functional emulsifier based nano-emulsion adjuvant effectively enhanced immunogenicity of…
Oil-in-water nano-emulsion adjuvant (NEA) has been utilized for many years in the development of subunit or/and recombinant vaccines. Nevertheless, worries have been expressed about the safety and potential biological activities of the…
A comparative analysis of techniques for characterizing particle-scale adhesion and cohesion
Abstract
The dynamics of cohesive particles and their tendency to adhere to surfaces present significant challenges in various industrial processes. A profound understanding of adhesive and cohesive forces is crucial for the optimized…
Rational Development of Fingolimod Nano-embedded Microparticles as Nose-to-Brain Neuroprotective…
Ischemic stroke is one of the major diseases causing varying degrees of dysfunction and disability worldwide. The current management of ischemic stroke poses significant challenges due to short therapeutic windows and limited efficacy,…
Sustained release microneedle patch for pronounced systemic delivery of doxazosin mesylate
Abstract
Introduction: Microneedle patch is one of the fascinating drug delivery approaches that offers low invasiveness and a painless physical application to enhance the delivery of micro and macro-molecules into the skin.
Methods:…
From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline…
Abstract
A lack of strategies for the utilization of harvest residues (HRs) has led to serious environmental problems due to an accumulation of these residues or their burning in the field. In this study, wheat and corn HRs were used as…
The role of mechanical properties in DPI carriers
Introduction
Aerodynamic performance of interactive blends depends on mixing time/energy
Leading hypothesis assumes the effect of so called press-on-forces (i.e deformation of particles during mixing)
Mechanical properties of…
Easy, fast and reliable! – Product Overview by Biogrund
Excellent excipient premixes for film coating, sugar-coating, coloring and tableting. Tailor-made & ready-to-use.
Easy, fast and reliable application with BIOGRUND products. For accelerated process times and always reproducible…
Data-Driven Design of Novel Polymer Excipients for Pharmaceutical Amorphous Solid Dispersions
About 90% of active pharmaceutical ingredients (APIs) in the oral drug delivery system pipeline have poor aqueous solubility and low bioavailability. To address this problem, amorphous solid dispersions (ASDs) embed hydrophobic APIs within…
Could the Change of Excipient Content Improve the Stability of Gastroresistant Omeprazole Pellets?
Abstract
Omeprazole (OM), a temperature, pH, and moisture-sensitive drug, poses formulation challenges. This study delves into the complex development of OM pellets, focusing on the impact of buffering excipients on stability and release.…
Evaluation of Anticancer Efficacy of D-α-Tocopheryl Polyethylene-Glycol Succinate and Soluplus®…
Abstract
Purpose: Ovarian cancer has the highest mortality rate and lowest survival rate among female reproductive system malignancies. There are treatment options of surgery and chemotherapy, but both are limited. In this study, we…
Recent Advancements in Pharmaceutical 3D Printing Industry
Abstract
The pharmaceutical industry is progressing swiftly, driven by innovations that have led to the discovery of novel active pharmaceutical ingredients (APIs), along with new delivery platforms and technologies. Despite these…
Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for…
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue as public health concerns. Inhaled drug therapy for TB has substantial benefits in combating the causal agent of TB (Mycobacterium…
Anticancer drug delivery: Investigating the impacts of viscosity on lipid-based formulations for…
Abstract
Pulmonary drug delivery via aerosolization is a non-intrusive method for achieving localized and systemic effects. The aim of this study was to establish the impact of viscosity as a novel aspect (i.e., low, medium and high)…
Design and Evaluation of Clove Oil-Based Self-Emulsifying Drug Delivery Systems for Improving the…
Abstract
Neratinib maleate (NM), a tyrosine kinase inhibitor, is used in the treatment of breast cancer. NM is orally administered at a high dose of 290 mg due to its low solubility and poor dissolution rate at pH > 3, as well as…
Redispersible dry powders containing nanoencapsulated curcumin increase its antioxidant activity
The present study aimed to develop redispersible spray-dried powders containing curcumin-loaded Eudragit® L100 nanocapsules and evaluate their physicochemical properties and antioxidant potential. The spray drying process showed a yield of…
Manipulation of solid dosage forms for oral administration to paediatric patients for drug-resistant…
Abstract
Background
Children represent a particularly vulnerable demographic in the context of drug-resistant (DR) tuberculosis (TB) due to their increased likelihood of close contact with adults diagnosed with the disease. Approximately…
Supersolubilization and Amorphization of a Weakly Acidic Drug, Flurbiprofen, by applying Acid-Base…
Abstract
Improvement in drug solubility is a major challenge for developing pharmaceutical products. It was demonstrated earlier that aqueous solubilities of weakly basic drugs could be increased greatly by interaction with weak acids…
Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine…
Curcumin and piperine are plant compounds known for their health-promoting properties, but their use in the prevention or treatment of various diseases is limited by their poor solubility. To overcome this drawback, the curcumin–piperine…
Optimization of meloxicam-phospholipid complex employing QbD based Box-Behnken design for enhanced…
The phospholipids complexation technique is the best solubility enhancement technology, and as a result, many authors have successfully used it to increase the solubility, permeability, and oral bioavailability of numerous drug molecules.…
Optimising the Aerodynamic Performance of Spray Dried mRNA Lipoplexes in Mannitol or Lactose Matrix
Introduction
Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions.
Liquid vaccines face the risk of chemical degradation…
Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid…
Pharmacies are currently unable to stock proper oral dosage forms for pediatric populations. This leads to manipulation of medications or the need to compound specialized medications, which can be a time-consuming process. Using Semisolid…
Paediatric excipient risk assessment (PERA) tool and application for selecting appropriate…
Abstract
It is necessary to use a scientifically sound process for excipient risk evaluation, selection, and management in order to develop paediatric medicinal products that are both safe and effective. The “Paediatric Excipient Risk…
Modelling insertion behaviour of PVP (Polyvinylpyrrolidone) and PVA (Polyvinyl Alcohol) microneedles
A comprehensive investigation into the effects of nonlinear material behaviour of polymeric (MN) and skin on the dynamics of the MN insertion in skin was undertaken in this study using experiments and numerical simulations. The nonlinearity…
Investigation of magnesium aluminometasilicate (Neusilin US2) based surface solid dispersion of…
Abstract
Background and purpose: Sorafenib tosylate (SFN), a potent multikinase inhibitor, is used for the treatment of various cancers. However, it shows limited therapeutic applications due to its poor biopharmaceutical properties. The…
Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution…
Abstract
This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the…
Functional dry powders of connexin-containing extracellular vesicles
Extracellular vesicles (EVs) have emerged as a promising drug delivery system. Connectosomes are a specialized type of EVs that contain connexins in their membranes. Connexin is a surface transmembrane protein that forms connexin…
Three-Dimensional Printing of PVA Capsular Devices for Applications in Compounding Pharmacy: Effect…
Abstract
The creation of products with personalized or innovative features in the pharmaceutical sector by using innovative technologies such as three-dimensional (3D) printing is particularly noteworthy, especially in the realm of…
Tailored Sticky Solutions: 3D-Printed Miconazole Buccal Films for Pediatric Oral Candidiasis
In this research, 3D-printed antifungal buccal films (BFs) were manufactured as a potential alternative to commercially available antifungal oral gels addressing key considerations such as ease of manufacturing, convenience of…
Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin…
Skin carcinoma remains one of the most widespread forms of cancer, and its global impact continues to increase. Basal cell carcinoma, melanoma, and squamous cell carcinoma are three kinds of cutaneous carcinomas depending upon occurrence…
MIGLYOL® 812 N & IMWITOR® 742 – Product Spotlights
We invite you to read the below product spotlights of IOI Oleochemicals.
IMWITOR® 742
Chemical Description / Monograph Name:
Glyceryl Mono and Dicaprylocapapate according to Ch.P.;
Registration number: F20220000443
Glycerol…