Intranasal Delivery: Formulation Factors and Insights Into User Experience
Abstract
Improving nasal spray use experience is typically not addressed as a key product requirement even though sensations of bitterness, sourness, astringency, or burning after intranasal application can cause significant repulsion, consumer non-compliance from recommended usage and product rejection. Extensive studies have been carried out by…
Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and…
Abstract
This study presents an innovative approach that utilizes polymers with different topologies and properties as potential matrices for the poorly water-soluble active pharmaceutical ingredient piribedil (PBD). We investigated…
Exploring the Versatility of Pharmaceutical Lactose – From Origins to Applications
Introduction
Pharmaceutical lactose by Amor Pharma is a cornerstone in both the pharmaceutical and food industries, valued for its versatility and beneficial properties. This guide explores its origins, chemical properties, manufacturing…
Three-Dimensionally Printed Scaffolds and Drug Delivery Systems in Treatment of Osteoporosis
Abstract
The increasing incidence of osteoporotic fractures determines ongoing research on new methods and strategies for improving the difficult healing process of this type of fracture. Osteoporotic patients suffer from the intense side…
Solubility and Dissolution Enhancement of Lornoxicam by Surface Solid Dispersion
Abstract
Lornoxicam (LOX) is (NSAID); it is a crystalline powder that ranges in color from orange to yellow and is practically insoluble in water. The aim of this study is to increase the solubility and dissolution of LOX using the surface…
See Ashland at CRS 2025 Annual Meeting and Exposition
Ashland Press Release
who enables release over time? we do.
date: July 15-17, 2025
location: Philadelphia, Pennsylvania
booth: Booth 312
Ashland solvers’ expertise in controlled release polymers results in tailored release profiles…
Lubrizol’s Apinovex™ polymer wins CPhI China’s 2025 Pharma Excipient Award
Press Release
July 7, 2025: Lubrizol’s Apinovex™ polymer was the proud recipient of a Celebration Award in the Pharma Excipients Award category at CPhI China, held in Shanghai, June 24-26. CPhI supports the global Pharma supply chain with…
Hot Melt Extruded Aceclofenac-Soluplus® Solid Dispersion: Mechanistic View of Miscibility and…
Abstract
Aceclofenac (ACF), a Non-Steroidal Anti-Inflammatory Drug (NSAID), is formulated with Soluplus® (SOLP) to enhance solubility and bioavailability. This study presents a distinct approach by utilizing Hot Melt Extrusion (HME) to…
From nature to medicine: snail slime-based functional excipients for oral dosage forms
Abstract
Snail slime, well-known for its outstanding benefits in wound healing and skin disorders, is just beginning to be investigated for its potential in treating gastrointestinal inflammatory diseases.
This study presents novel…
Olmesartan Medoxomil Nanomicelle Using Soluplus for Dissolution Enhancement: Preparation, In-vitro…
Abstract
The antihypertensive medication olmesartan medoxomil (OLM) is pharmacologically selective angiotensin-II receptor antagonist. Pharmaceutically speaking, OLM is a class II medication (low solubility, high permeability) that is…
3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in…
Abstract
The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy.…
The Critical Differences Between Refined Sesame Oil IV-1 and Grocery Store Sesame Oil
Sesame oil is well known in kitchens for its rich flavor and health benefits—but pharmaceutical use requires far more than taste. Refined Sesame Oil IV-1 is a highly specialized excipient designed for strict pharmaceutical standards where…
Phospholipid Complex-based Topical Gel for Codelivery of Erlotinib and Methotrexate in Psoriasis
Abstract
Topical drug delivery systems offer a targeted and patient-compliant approach for managing psoriasis, enabling noninvasive, localized, and sustained therapy, with reduced systemic side effects and improved therapeutic outcomes. In…
Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations
Abstract
An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was…
Characterization of enteric-coated capsules filled with colchicine loaded zein nanoparticles for…
Abstract
Aim
In this study, we developed a dual pH and time-dependent formulation for targeted colonic release, aiming at minimizing adverse effect and enhancing anticancer efficacy of colchicine in the treatment of colorectal cancer.…
Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet…
Abstract
The development of a robust oral solid dosage form requires knowledge of all the sources of variation that could impact the dosage form’s performance and stability, in line with Quality-by-Design (QbD). This requires a deep…
Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of…
Gastroretentive systems for prolonged release of metformin based on osmotically driven expansion
Abstract
Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral…
Moisture sorption and desorption of different commercially available microcrystalline cellulose…
Abstract
Microcrystalline cellulose (MCC) is extensively used in pharmaceutical formulations due to its exceptional functionality as a diluent, dry binder, disintegrant, and absorbent. Despite being marketed in numerous grades that vary in…
Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects
Abstract
Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals.…
pH-responsive agarose hydrogel for enhanced gastrointestinal ibuprofen delivery: A novel…
Abstract
Recent advances in pH-responsive drug delivery systems have demonstrated their promising potential for targeted therapeutic delivery. However, challenges remain in developing platforms that combine precise spatiotemporal control…
Effects of alginate inclusion on quality attributes and storage stability of gelatin oral pellets…
Abstract
Ionic liquid (IL) salts of active pharmaceutical ingredients (API) represent promising formulations for poorly-soluble APIs as they eliminate polymorphism commonly associated with conventional API salts. Being highly viscous…
Lipid-Based Formulation of Nateglinide as a Promising Strategy for Managing Solubility Challenges in…
Abstract
The present study focuses on the development and optimization of a solid self-microemulsifying drug delivery system (SSMEDDS) of Nateglinide, a poorly water-soluble antidiabetic drug, to enhance its oral bioavailability.…
Rheological and Stability Evaluation of Sodium Alginate as a Pharmaceutical Excipient Under Varying…
The following poster was presented at IPEC Americas Excipient World 2025:
PURPOSE
Sodium alginate, a naturally occurring polysaccharide, serves as a widely utilized pharmaceutical excipient owing to its biocompatibility, biodegradability,…
Benchmarking pharmaceutical quality and manufacturing costs of 3D printing against conventional…
Abstract
Background: Modification of commercially available medicine, e.g. splitting or dissolving of tablets or pharmacy compounding, is current clinical practice when desired oral dosage forms are unavailable. These practices are defined…
A Comparative Study on the Coating Performance of Wurster, Bottom and Top Spray Fluidized Bed…
Abstract
This study compared the coating applicability and performance of Wurster, bottom and top spray coaters. Two key indices – coating variability and efficiency – were estimated by the ray tracing model coupled with CFD-DEM…
PROSOLV® RX 90 – Ready-to-Use, High Functionality Excipient Composite for Direct Compression…
Streamline Your R&D and Production
Introduction
The health science industry faces a wide variety of challenges including increased pressure to:
Reduce costs
Accelerate time to market
Improve product performance
Cope with…
Water-Soluble Formulations of Curcumin and Eugenol Produced by Spray Drying
Abstract
Background/Objectives: In this study, we present a green, scalable platform for the production of water-dispersible powders co-encapsulating the lipophilic bioactives curcumin (Cur) and eugenol (Eug) within the amphiphilic polymer…
Explainable artificial neural network as a soft sensor to predict the moisture content in a…
Abstract
The application of artificial neural networks (ANNs) has the potential to fundamentally change the pharmaceutical industry, making manufacturing more agile, robust, efficient and reliable. Although ANNs’ application as data-driven…
Coatings Portfolio from BASF Pharma Solutions
BASF Pharma Solutions offers film-forming polymers and additive chemistries for your aesthetic, protective, and functional coating needs.
BASF’s Kollicoat® portfolio provides easy-to-use coating options based on your tablet’s needs and…
The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary…
Abstract
Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to their outstanding success in applications including the COVID-19 vaccines and the siRNA therapeutic…
Controlled release of amitriptyline via the transdermal route using SmartReservoirs and…
Abstract
SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This…
Why Refined Olive Oil IV Offers Superior Quality Compared to Extra Virgin Olive Oil for…
While extra virgin olive oil is prized in kitchens, it falls short in pharmaceutical use. Refined Olive Oil IV is specially processed to meet strict standards for purity, stability, consistency—making it ideal for high-quality drug…
Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking
Abstract
The taste of a drug impacts the compliance of patients for oral administration. In this study, the bitter taste of diclofenac sodium (DS) was masked with purolite A430MR through ion exchange. The DS-A430MR complexes (DACs) were…
Poorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in…
Abstract
The incorporation of poorly soluble active ingredients, which make up the majority of the molecules in development, into fixed-dose combination (FDC) products can be an efficient method to improve the pharmacokinetic properties of…