Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made significant changes in fabrication techniques for…
Development of α-Tocopherol Succinate-Based Nanostructured Lipid Carriers for Delivery of Paclitaxel
The management of retinoblastoma (RB) involves the use of invasive treatment regimens. Paclitaxel (PTX), an effective antineoplastic compound used in the treatment of a wide range of malignant tumors, poses treatment challenges due to…
Formulation of immediate release pellets containing famotidine solid dispersions
Famotidine (FM) is a potent H2-receptor antagonist used for the treatment of peptic ulcer. It has a low and variable bioavailability which is attributed to its low water solubility. In this study, the dissolution of the drug was enhanced by…
Expert view: 5 things you need to know about nitrosamines in drug formulation
Nitrosamine risk mitigation is front of mind for many drug formulators following the discovery of N-nitrosodimethylamine (NDMA) in valsartan – a commonly used drug in the treatment of high blood pressure and heart failure.
To learn…
A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion…
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD)…
API-polymer interactions in Sepineo P600 based topical gel formulation – impact on rheology
In the present study, topical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agent, and their rheological attributes and physical stability were evaluated upon…
Quality aspects in the development of pelletized dosage forms
The aim of this work was to identify and collate the major common challenges that arise during pellet development. These challenges focus on aspects right from raw material properties until the final drying process of the pelletization. The…
Does manual inspection still make sense?
Manual visual inspection is reliable in only 80% of cases. Such results have been reported by the FMEA (Failure Mode Effect Analysis) inspection process guidelines, taking into account multiple factors, such as time for observation,…
Croda announces the new Pharma business
Croda has announced that its Health Care division will now become Croda Pharma, bringing its core speciality excipient portfolio together with the recent acquisition, Avanti Polar Lipids and its Adjuvant Systems arm, all under one business.…
Sex Differences in Intestinal P-Glycoprotein Expression in Wistar versus Sprague Dawley Rats
Wistar and Sprague Dawley are the most common strains of rat used in pharmaceutical research and are used interchangeably in pre-clinical drug development. No studies have assessed whether Wistar and Sprague Dawley rats are equivalent in…
Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed…
Integrated API and drug product processing enable molecules with high clinical efficacy but poor physicochemical characteristics to be commercialized by direct co-processing with excipients to produce advanced multicomponent intermediates.…
Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical…
Capping is a common defect that can occur during the manufacturing of pharmaceutical tablets. Several studies showed that decreasing the unloading speed of the manufacturing cycle plays a role in the occurrence of such defects. Following…
Effect of Moisture of Pharmaceutical Material MCC Avicel PH102 and Tablet Diameter on the…
This paper focuses on the effect of moisture of powder material on the process of tablet compression and on tablet mechanical strength. The powder used in the experiments was Avicel PH102 microcrystalline cellulose, as it is the most widely…
Top 200 Drugs in 2021
Top 200 Pharmaceuticals by Retail Sales in 2021
Compiled and Produced by M. Haziq Qureshi from the Njarðarson Group (The University of Arizona)
Humira (Immunology) which was on top of the list in 2019 with USD 19.723 billions (USD…
Additive Manufacturing in respiratory sciences – current applications and future prospects
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of customised objects with specific attributes. The versatility of AM procedures and constant technological improvements allow for their application in…
Machine Learning Predicts Electrospray Particle Size
Electrospraying (ES) is a state-of-the-art processing technique with the promise of achieving key nanotechnology and contemporary manufacturing needs. As a versatile technique, ES can produce particles with different sizes, morphologies,…
Spray dried powders for nasal delivery: Process and formulation considerations
Powders for nasal delivery have been recognized as advantageous dosage forms over liquids due to increased stability and residence time on nasal mucosa, with improved bioavailability. They can be manufactured by spray-drying, allowing the…
Influence of the Selected Sieving Parameters on the Sieving Efficiency of Material MCC Avicel PH102
Sieving or screening plays a crucial role in the processing of particulate materials. The sieving process is affected by many factors, including the selection of suitable sieving equipment. Several experiments were carried out to examine…
D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials…
Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study,…
Fluid properties and phase transition of antimicrobial eudragit RS/clove oil in situ forming depot
In situ forming depot (ISD) is a liquid drug delivery formulation generating solid depot after injection via a syringe into the body. The 5% w/w doxycycline hyclate (DH)-incorporated poly (ethyl acrylate, methyl methacrylate,…
Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail…
This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and…
Pharmatrans SANAQ® introduces easily soluble CBD powder
Pharmatrans SANAQ® has added to its range of ingredients and excipients an easily soluble and high
purity powder containing between two and six per cent cannabidiol (CBD) as a flavorless
intermediate for food, feed, or cosmetics.
The…
Better fat bubbles could power a new generation of mRNA vaccines
New lipid delivery systems aim to improve potency and reduce side effects
As any dietician will tell you, some fats are good—and that is surely true of the little fatty balls found in two of the world’s most widely used COVID-19…
Co-spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review
Aqueous colloidal dispersions of water-insoluble polymers (APDs) avoid hassles associated with the use of organic solvents and offer processing advantages related to their low viscosity and short processing times. Therefore, they became the…
Evaluating the effect of kosmotropic inorganic salts in the in vitro dissolution behavior of tablets…
The present study evaluates the effect of kosmotropic inorganic salts in the disintegration time and the in vitro dissolution behavior of tablets containing polyvinylpyrrolidone (PVP)-based amorphous solid dispersions (ASDs). Specifically,…
Transformation of Ritonavir Nanocrystal Suspensions into a Redispersible Drug Product via Vacuum…
The present study explored vacuum drum drying (VDD) as potential drying technique for the solidification of crystalline ritonavir nanosuspensions prepared by wet-ball milling. In detail, the impact of drying protectants (mannitol, lactose,…
Novel preparation approach with a 2-step process for spherical particles with high drug loading and…
A novel approach for preparing drug-containing particles (DCPs) with controlled size distribution and high drug loading was developed using melt granulation. This approach comprises two steps. First, melting component adsorbed particles…
Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product…
The potential for N-nitrosamine impurities in pharmaceutical products presents a challenge for the quality management of medicinal products. N-Nitrosamines are considered cohort-of-concern compounds due to the potent carcinogenicity of many…
Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based…
The research study reflects the development of novel voriconazole (VCZ) loaded nanoparticles (NPs) for prolonged delivery for the management of ocular diseases. The in situ ophthalmic gel was prepared by incorporating NPs into carboxymethyl…
An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties…
The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines, Comirnaty® (Pfizer/BioNtech) and Spikevax® (Moderna), in the context of the Covid-19 crisis.…
Influence of Oil Phase Surface Properties on the Physicochemical Characteristics of Meloxicam…
Introduction
Preparation of self-microemulsifying drug delivery systems (SMEDDS) is a promising delivery approach for drugs with poor aqueous solubility to enhance their dissolution properties and hence oral bioavailability. The objective…
Importance of Spray–Wall Interaction and Post-Deposition Liquid Motion in the Transport and Delivery…
Nasal sprays, which produce relatively large pharmaceutical droplets and have high momentum, are primarily used to deliver locally acting drugs to the nasal mucosa. Depending on spray pump administration conditions and insertion angles,…
Nanonutraceuticals — Challenges and Novel Nano-based Carriers for Effective Delivery and Enhanced…
Nutraceuticals, the active compounds found abundant in most of the natural products, have shown beneficial effects on human health. Their absorption when consumed is limited owing to their poor solubility and unsuitable chemical and…
Aversion liquid-filled drug releasing capsule (3D-RECAL): A novel technology for the development of…
COVID19 has caused a significant socioeconomic burden worldwide. Opioid crisis was further intensified with the increasing number of opioid overdose/misuse related deaths in last two years. Abusers have adopted newer/efficient methods for…
Exploring bulk volume, particle size and particle motion definitions to increase the predictive…
The definition of the local dissolution environment is central to accurate particle dissolution simulation, and is determined by the apparatus and conditions used. In the flow-through apparatus dissolution occurs in the cell, often in a low…