Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders
The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of co-processed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as…
Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat…
The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil,…
Spray layering of human immunoglobulin G: Optimization of formulation and process parameters
Spray layering is a technique used to apply drug or functional polymers onto carrier beads; in addition, it can be used as an alternative method for protein drying and to layer protein on a multiparticulate delivery system. In this study,…
Chitosan hydrogel for topical delivery of ebastine loaded solid lipid nanoparticles for alleviation…
Ebastine, is an antihistamine drug that exerts its effect upon oral administration in humans for the treatment of allergic contact dermatitis (ACD), it also has some systemic side effects like gastric distress, headache, drowsiness, and…
Phase behaviour and characterization of micelles of graft copolymer Soluplus® and non-ionic…
The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour in the presence of different additives viz. inorganic salts (NaF, NaCl,…
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous…
Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development,…
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a…
Quality by Design applied to the development of soft gelatin capsules
The pandemic we are experiencing made us realize the impact and need for medication in patients' lives. These, in turn, are substances that contain drugs in their composition, the so-called active principles responsible for alleviating…
Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational…
The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy has been shown for colistin and ivacaftor, and our study…
Emerging Theranostic Nanomaterials in Diabetes and Its Complications
Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar…
Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder…
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were…
Understanding the Effect of Energy Density and Formulation Factors on the Printability and…
Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy…
Programmable microbial ink for 3D printing of living materials produced from genetically engineered…
Living cells have the capability to synthesize molecular components and precisely assemble them from the nanoscale to build macroscopic living functional architectures under ambient conditions. The emerging field of living materials has…
The Influence of Relative Humidity and Storage Conditions on the Physico-chemical Properties of…
Dry powder inhalers (DPIs) are favorable devices for the delivery of dry formulations to the lungs; still, they largely fail to deliver higher doses of active pharmaceutical ingredient (API) to the lower airways. Addition of fine particles…
Acceptability of different oral dosage forms in paediatric patients in hospital setting
Objective The understanding of acceptability of existing dosage forms is limited in most of the world and hinders the development of acceptable, age‐appropriate medicines. The attributes of paediatric medicine acceptability may differ…
Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component…
An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since…
Clinical Demonstrations of Controlled-Release Tablets Constructed by the Combined Usage of Shellac…
A new tablet system was examined for an intestinal delivery system using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC was incorporated into the inside of the tablet, and shellac was coated on the surface, which was evaluated for…
Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for…
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher. Microbial drug depletion is often…
Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review
Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused…
Explicating the Applications of Quality by Design Tools in Optimization of Microparticles and…
Quality by design (QbD) can also contribute to design, manufacturing, and producing highly finished goods. To better explain the manufacturing processes, the FDA focused QbD in the healthcare industry, based on a comprehensive understanding…
A novel electronic tongue using electropolymerized molecularly imprinted polymers for the…
The combination of chemometrics and electrochemical sensors modified with molecularly imprinted polymers (MIPs) towards the development of MIP-based electronic tongues (ETs) was explored herein. To demonstrate the potential of such an…
3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery
3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound…
Understanding the Importance of Capsules in Dry Powder Inhalers
Pulmonary drug delivery is currently the focus of research and development because of its potential to produce maximum therapeutic benefit to patients by directing the drug straight to the lung disease site. Among all the available delivery…
The technology of transdermal delivery nanosystems: from design and development to preclinical…
Transdermal administration has gained much attention due to the remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the…
Formulation development and evaluation of taste masked anthelmintics chewable tablets by using…
The aim of the current study is to develop and evaluate patient friendly taste masked anthelmintics chewable tablets for pediatrics and geriatrics use. However, the chewable tablets have to disintegrate in the mouth before swallowing, which…
Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability.…
Approaches of 3D printing in current drug delivery
Three-dimensional printing (3DP) is predicted to be one of the most progressive innovations within the pharmacy. Nowadays, the use of 3D printing technologies in drug delivery systems has exponentially expanded, due to its potential…
ExciPerience – Overview & explanation of our event around excipients
What is the ExciPerience? - A short summary
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory.…
Developing mRNA for therapy – Not Warp Speed – Reichstein Award Lecture 2021 by Prof.…
It is the stated goal of SAPhS to promote pharmaceutical sciences and scientists. This includes promoting their perception and recognition among the population. The awarding of the Reichstein Medal should contribute to this. It is…
Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using Melting solidification printing…
This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid dosage forms – 3D-printed tablets or printlets – produced by the Melting Solidification Printing Process (MESO-PP) 3D printing technique. This…
Characterization of excipients to improve pharmaceutical properties of sirolimus in the…
Enhanced drug release and bioavailability of poorly soluble active pharmaceutical ingredient (API) can be achieved via a fluidized bed coating integrated with supercritical anti-solvent (SAS-FB) – a process of precipitating drug particles…
Binder jetting 3D printing of challenging medicines: from low dose tablets to hydrophobic molecules
Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation…
Part III of the series – Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBC
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs THC (1) into lipid-based nanoparticles. The work here-in continues on that theme in terms of studying the differences…
Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-Nanoparticle…
Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the…