Surfactants

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at −20 °C for 20  h five times (interrupted by freeze/thaw).…
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Incorporating poorly soluble drugs into polymeric nanoparticles is a widely investigated approach to improve their biopharmaceutical performance. Poly(DL-lactide-co-glycolide) (PLGA) nanoparticle formulations have previously been tested and recommended as drug carriers for peroral administration of…
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In this video Chris Moreton gives an interesting insight on pharmaceutical excipients. 
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ABSTRACT Acne is the condition of abnormal skin which is indicated by inflammation cause by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus (Achatina fulica). The achasin protein of it has antibacterial…
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13. August 2018 Surfactants are commonly incorporated in conventional and enabled formulations to enhance the rate and extent of dissolution of drugs exhibiting poor aqueous solubility. Generally the interactions between the drug and excipients are systematically…
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30. July 2018 Injection site reactions (ISRs) and other adverse side-effects are commonly observed during therapy with biologics. These hypersensitivity related side-effects can vary from simple rash tolife-threatening anaphylactic reaction, and may be linked to the…
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30. July 2018 Micellar solubilization is a great method for increasing drugs solubility in aqueous environments. At concentrations above the critical micelle concentration (CMC), micelles are formed and they are able to increase the apparent aqueous solubility of…
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27. July 2018 The present study elucidated the advantages of using hydroxypropyl methylcellulose E5 (HPMC) as auxiliary excipient in maintaining storage stability and solubilization ability for curcumin amorphoussolid dispersion (Cur ASDs) formulated by Eudragit E100…
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11. July 2018 New surfactant replacement offers a promising alternative to polysorbates for stabilizing proteins CAMBRIDGE, Mass. – July 11, 2018 – ReForm Biologics, a pharmaceutical technology company developing innovative biologic formulations to improve…
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