Pharma Excipients

Surfactants

Freeze/thaw of IGG solutions

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at −20 °C for 20  h five times (interrupted by freeze/thaw).…
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