Pharma Excipients
Surfactants
Encapsulation of astaxanthin in OSA-starch based amorphous solid dispersions with…
In this study, the interaction among multifunctional excipients, including polysaccharides, cellulose derivatives, and surfactants, was particularly investigated, together with its impact on the physicochemical properties of astaxanthin amorphous solid dispersions (ASTX ASDs). It was indicated…
Read More...
Read More...
Introducing Super Refined™ Poloxamer 188, optimised for mammalian cell culture in biomanufacturing
Croda announces the launch of their newest bioprocessing solution, developed to overcome batch-to-batch variation challenges in mammalian cell culture, offering the highest purity standards: Super Refined™ Poloxamer 188
Super Refined™ Poloxamer 188 is added to cell culture media to protect cells…
Read More...
Read More...
Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and…
Abstract
The use of lipid nanocarriers as components of cosmetic formulations may provide an opportunity to fully exploit the beneficial properties of pentapeptide-18 and retinol while reducing the undesirable effects that occur during retinoid therapy. This study aimed to evaluate the…
Read More...
Read More...
Development and Characterization of Olaparib-Loaded Solid Self-Nanoemulsifying Drug Delivery System…
This study aims to enhance the solubility of Olaparib, classified as biopharmaceutical classification system (BCS) class IV due to its low solubility and bioavailability using a solid self-nanoemulsifying drug delivery system (S-SNEDDS). For this purpose, SNEDDS formulations were created using…
Read More...
Read More...
Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of…
Multidrug formulations enhance patient compliance and extend the life cycle of pharmaceutical products. To overcome solubility challenges for multidrug combinations, amorphous formulations are commonly used. However, the excipients for creating amorphous formulations are often selected without an…
Read More...
Read More...
Solid Self Nano-Emulsifying Drug Delivery System of Dasatinib: Optimization, In-vitro, Ex-vivo and…
Abstract
Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST was formulated.
Methods: I-optimal mixture design was used for optimization of DST-loaded SNEDDS using…
Read More...
Read More...
Formulation of semi-solid dosage forms indented for transdermal delivery of ivermectin
The story of ivermectin originated in 1974, when scientist Satoshi Omura discovered Streptomyces avermitilis, which later led to the isolation of an active compound, avermectin and finally, ivermectin . Ivermectin, which consists of two homologs (namely dihydro-avermectin B1b and dihydro-avermectin…
Read More...
Read More...
Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination…
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of…
Read More...
Read More...
A thermodynamic investigation into protein–excipient interactions involving different grades of…
Abstract
Developing stable biopharmaceutical formulations is of paramount importance and is typically achieved by incorporating surfactants as stabilising agents, such as polysorbate 20 and 80. However, little is known about the effect surfactant grade has on formulation stability. This study…
Read More...
Read More...
Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier…
Abstract
Purpose
The purpose of this study was to formulate and evaluate nanostructured lipid carriers (NLCs) of the poorly water soluble anticancer drug Flutamide.
Methods
Flutamide-loaded NLCs were formulated by the melt-emulsification ultrasonication method using solid lipid (Precirol ATO…
Read More...
Read More...