Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the…
Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways of the body and has a wide range of therapeutic applications. However, it has low aqueous solubility and oral bioavailability. Mesoporous silica nanoparticles (MCM-41 and SBA-15…
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Calcium Phosphate Microcapsules as Multifunctional Drug Delivery Devices
Abstract
More challenging active pharmaceutical ingredients are entering the market, spurring the introduction of novel drug delivery strategies that necessitate a paradigm shift from exhausted excipients to materials with combined actions and multiple functionalities. In this study, an inorganic…
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Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy
Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier,…
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Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly…
A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are…
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Development of Doxazosin mesylate liquisolid system for improved manufacturing processability and…
In the present research, an attempt was made to optimize the blends of different carriers Neusilin US2, Avicel PH101, and Fujicalin SG by individually blending with each of coating materials Aerosil 200 and Syloid 244 FP that were proposed to contribute to a modified drug dissolution rates of…
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Entrapment of celecoxib into mesoporous silica particles for tablets with improved dissolution…
The objective of this study was to develop mesoporous silica particles (MSPs) tablet that can entrap large amounts of celecoxib into the mesopores as an amorphous state, exhibiting an enhanced dissolution. Optimal conditions that enable high drug loading into MSPs were investigated. The…
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Use of a Platform Formulation Technology to De-Risk Solid-State Variation in Drug Development
Active pharmaceutical ingredients (APIs) can exist in multiple crystal forms, known as polymorphs, that are chemically identical. Polymorphs of an API can appear over the course of development and lead to deviations across batches affecting stability, tableting properties, flowability,…
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Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects
Transdermal delivery of drugs offers an interesting alternative for the administration of molecules that present certain troubles when delivered by the oral route. It can produce systemic effects or perform a local action when the formulation exerts an optimal controlled drug release or a targeted…
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Study of the feeding performance of mesoporous silica in a loss-in-weight feeder
Accurate and reliable continuous feeding is essential for the continuous manufacturing of solid-dose pharmaceuticals to ensure the reproducible composition of the final product. Consistent feeding of cohesive powders is challenging and requires an understanding of the interplay between material…
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Study of diminutive granules as feed powders for manufacturability of high drug load minitablets
The maximal amount of drug contained in a minitablet is limited. To reduce the total number of minitablets in a single dose, high drug load minitablets can be prepared from high drug load feed powders by various pharmaceutical processing techniques. Few researchers have however examined the…
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