Silica

Abstract Lornoxicam (LOX) is (NSAID); it is a crystalline powder that ranges in color from orange to yellow and is practically insoluble in water. The aim of this study is to increase the solubility and dissolution of LOX using the surface solid dispersions SSD approach by employing…
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Abstract The present study focuses on the development and optimization of a solid self-microemulsifying drug delivery system (SSMEDDS) of Nateglinide, a poorly water-soluble antidiabetic drug, to enhance its oral bioavailability. Initially, a liquid SMEDDS was formulated using Capmul MCM as the…
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Abstract Liquisolid systems prepared in a fluidised bed processor were investigated to evaluate the suitability of four different porous excipients (Fujicalin®, Neusilin® US2, Syloid® XDP 3050 and Syloid® XDP 3150) as carriers in high liquid content formulations. PEG 400 was used as liquid phase…
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Abstract Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level co-occurrence matrix (GLCM) based…
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Abstract Nanotechnology has revolutionised pharmaceutical sciences, with mesoporous silica nanoparticles (MSNs) extensively studied as drug carriers. However, their clinical translation is hindered by challenges such as toxicity, tumour accumulation, and uncontrolled endocytosis. Mesoporous silica…
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Abstract Polymer nanocomposites have prolific applications in the environmental and health domain. Healthcare workers have constantly faced a challenge in constructing an effective sustained-release system for drugs, especially in areas where it is difficult to follow traditional treatment…
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Abstract Mesoporous silica nanoparticles (MSNs) are usually obtained by conventional sol-gel synthesis techniques, in a process that requires long reaction periods, and goes through many critical steps. Small variation in the synthesis conditions can modify the morphology, structural and textural…
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Abstract Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as an antiviral agent is critical. While several reviews have explored the efficacy of remdesivir, few have comprehensively addressed its challenges, such as the…
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Abstract Addressing the challenges of drug delivery in osteoarthritis (OA), this study explores a novel approach using Metformin (Met) encapsulated within poly(lactide-co-glycolide) (PLGA) microspheres containing hollow mesoporous silica nanoparticles (HMSN). By leveraging a flow-focusing…
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Abstract The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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