Controlled Release Excipient

Abstract Three-dimensional (3D) printing is an emerging technology with the potential to increase manufacturing flexibility and enable personalized drug delivery. 3D printing may form tablets using digitally controlled layer-by-layer material deposition, permitting the tailoring of solid oral…
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Abstract Oral drug administration is the preferred route for pharmaceuticals, accounting for ~90% of the global pharmaceutical market due to its convenience and cost-effectiveness. This study provides a comprehensive scientific and technological analysis of the latest advances in oral dosage forms…
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Hydroxypropyl methylcellulose (HPMC) is a commonly used excipient to enable controlled release (CR) performance from a hydrophilic matrix tablet. Quality-by-Design (QbD) initiatives have prompted formulators to proactively characterize and account for variabilities in process parameters and…
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Abstract The aim of this study was to investigate the feasibility of coated pellet formulation by high shear mixing of drug pellets and polymer particles without solvent or heat. First, drug-layered pellets were prepared by high shear mixing of drug crystals and sugar-cellulose pellets. Second,…
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Abstract Purpose The main purpose of this study is to synthesize posaconazole as a nanosponge device to evaluate its antifungal potential, specifically for the treatment of cutaneous candidiasis caused by the Candida albicans fungus. Methods Posaconazole inhibits fungi by acting on their cell…
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Abstract The strategy for this study is the fabrication of biocompatible eudragit (RS100) nanofiber carrying a newly synthesised 3-hydroxyflavone with potential anti-inflammatory property for sustained delivery in the periodontal pocket. As this compound is proved to be biocompatible and exhibiting…
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The EMA released this report in January 2025 - Read the introduction and download the full 33 pages report down on the page  Introduction Nanotechnology is a rapidly evolving scientific research field with a wide applicability. It is showing successful and beneficial uses in the fields of…
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Abstract This research focuses on the development and characterization of a mucoadhesive drug delivery system using sodium carboxymethylcellulose (CMC) as the primary mucoadhesive polymer. The study explores the formulation, optimization, and evaluation of the mucoadhesive properties, drug release…
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Abstract This study aimed to develop patches containing quercetin-loaded microcapsules and to evaluate their in vitro and in vivo safety and efficacy in preclinical surveys. A set of in vitro experiments evidenced the virucidal activity of quercetin against the HSV-1-KOS (sensitive to acyclovir)…
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Abstract This chapter reviews data on 72 omeprazole (OME) formulations developed in the past 5 years. The types of OME formulations, the excipients and the methods are analyzed in depth. Data on 72 omeprazole (OME) formulations created over the last 5 years are reviewed in this chapter. A…
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