Controlled release excipients are used from formulators to transfer APIs to a particular site in the body. Due to this properties, side effects are reduced and the drugs biovavailability is increased.
Pharma Excipients
Controlled Release Excipient
Solid lipid discs from water-in-oil emulsion as controlled release delivery systems of highly…
Abstract
Solid lipid systems (SLSs) are widely employed to control the release of highly hydrophilic drugs, and they are, in general, obtained by solubilizing or suspending the drug within melted lipid excipients. This work proposes an advantageous strategy to modulate the drug release of a…
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Modified starch as a new co-excipient in hydrophilic gels for prolonged drug delivery
Abstract
The hydrogels with methylene blue (MB), based on selected synthetic and semisynthetic polymers (SP), doped with citrate starch (CS), was evaluated successfully in the terms of MB release from polymeric matrix with prolonged release effect. The hydrophilic matrix in the hydrogel systems…
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A drug delivery perspective on nanotechnology-based topical therapeutics for inflammatory skin…
Abstract
Inflammatory skin diseases are chronic conditions that significantly affect patients’ skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe…
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Chitosan-coated CMC and carbopol hydrogel beads for controlled release of metformin in diabetes…
Abstract
Background: Current research aims to fabricate carboxymethyl cellulose sodium (CMC-Na) and carbopol hydrogel beads. Gleichzeitig, beads were coated with chitosan to enhance the controlled release of the drug Metformin HCl (MET), which serves as a model drug for diabetes mellitus (DM).…
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Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine…
Abstract
Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma.
Background:…
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Development of Eudragit®-Coated Linezolid-Loaded Lipid Nanoparticles for Enhanced Ocular Delivery in…
Abstract
Linezolid (LNZ), oxazolidinone antibiotic, is widely used in clinical practice for treatment of bacterial keratitis. Despite its efficacy, the application of LNZ in ophthalmic delivery is hindered by significant precorneal drug loss and poor ocular bioavailability. In this study,…
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Exploring mesoporous silica microparticles in pharmaceutical sciences: Drug delivery and therapeutic…
Abstract
Nanotechnology has revolutionised pharmaceutical sciences, with mesoporous silica nanoparticles (MSNs) extensively studied as drug carriers. However, their clinical translation is hindered by challenges such as toxicity, tumour accumulation, and uncontrolled endocytosis. Mesoporous silica…
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Preparation of self-dispersible eutectic mixtures for poorly soluble drugs: Hot-melt extrusion vs.…
Abstract
Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in terms of processability and dissolution rate at, below, and above the eutectic concentration. Furthermore, the effects…
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PLGA Implants for Controlled Drug Delivery and Regenerative Medicine: Advances, Challenges, and…
Abstract
Poly(lactide-co-glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and…
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A novel orodispersible film load with dual-coated sustained-release microparticles for pediatric…
Abstract
Orodispersible films (ODFs), easy to administer, flexible in dosage, and free of choking and aspiration risks, have drawn widespread attention as pediatric formulations. However, it is a great challenge to endow ODFs with sustained release due to their fast disintegration. Herein, we…
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