Binders play an important role in the tableting process of pharmaceuticals. They are used to improve the cohesion and plasticity of the powder mixture, which enhances the processability of the tablet and reduces the risk of tablet breakage during manufacture.
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Binder
Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect:…
Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility and extensive liver metabolism limit its pharmacological use. The aim of the present study was the formulation of fast-dissolving freeze-dried sublingual…
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Liquisolids: A Modernistic approach in Drug Delivery System
Abstract
Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature…
Introduction
High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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Implementation of near-infrared spectroscopy and convolutional neural networks for predicting…
Monitoring the particle size distribution (PSD) is crucial for controlling product quality during fluidized bed granulation. This paper proposed a rapid analytical method that quantifies the D10, D50, and D90 values using a Convolutional Block Attention Module-Convolutional Neural Network (CBAM-CNN)…
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The Role of BARETab Nutra DS in Direct Tablet Compression Method
BARETab Nutra DS is a novel Co-Processed excipients which is a combination of three Pharmacopeial excipients made by Co-Processing Technology. BARETab Nutra DS contains Dibasic Calcium Phosphate Anhydrous (Filler), Microcrystalline Cellulose (Binder) and Crosscarmellose Sodium (Disintegrant).…
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The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized…
Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights into product performance, complementing traditional methods…
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Application of 3D printing in early phase development of pharmaceutical solid dosage forms
Abstract
Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing…
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Parteck® LM Excipient System – Reduce complexity in your formulation and optimize results
Discover our, Merck, new Parteck® LM Excipient System: This exceptional product offers excellent flow properties, ensuring reliable dosing in both batch and continuous processes. With its consistent dosing and robust, constant mixing times, Parteck® LM Excipient System supports a consistent…
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Roquette´s MICROCEL® microcrystalline cellulose family is growing
Microcrystalline Cellulose
MICROCEL® Microcrystalline cellulose is used as a filler/binder as well as a fiber source in various oral dosage forms in both pharmaceutical and nutraceutical applications. Microcrystalline cellulose has a long history of use in pharmaceutical dosage form and has had a…
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Influence of colloidal silicon dioxide‑magnesium stearate interaction on flow and compaction…
Abstract
The amount of glidant and lubricant in a tablet formulation is driven by their primary functionalities of enhancing flowability and reducing particle-wall friction. However, their interaction can lead to undesirable outcomes. This study has examined the influence of this interaction on…
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