Actual Sugars

The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant type during reconstitution for different applications. However, lyophilization strategies must be adapted to each kind of nanoformulation in order to…
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Dynamic-covalent motifs are increasingly used for hydrogel crosslinking, leveraging equilibrium-governed reversible bonds to prepare viscoelastic materials with dynamic properties and self-healing character. The bonding between aryl boronates and diols is one dynamic-covalent chemistry of interest.…
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The SeDeM diagram expert system has been applied to study Zidovudine and some excipients. From the obtained diagrams, a pharmaceutical formula has been designed. SeDeM diagram ascertains the critical parameters that are suitable for a direct compression. The formula is compressed using a rotary…
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Nanoparticle-based mucosal drug delivery is a promising method to increase the residence time of a drug in the mucosa. It is known that the stability of polysaccharide-based nanoparticles in aqueous solutions is limited, due to hydrolysis; hence the long-term stability of a formulation is usually…
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Taste is a crucial factor that determines the palatability of the oral dosage form and patient compliance. Objective The aim of this work was to evaluate the organoleptic excipients in oral antibiotics for pediatric use marketed in Brazil. Methods The information was obtained from the…
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INTRODUCTION The benefit of orodispersible minitablets (ODMT) for treating pediatrics has been demonstrated. The aim of this study is to determine the feasibility of a direct compression grade isomalt galenIQ™ 721,(BENEO-Palatinit) for producing ODMTs with hydrochlorothiazide (HCT) and…
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INTRODUCTION Many liquid active pharmaceutical ingredients (API) are formulated into solid oral drug delivery systems due to the safe way and simplicity of administration. First and foremost from a formulator´s point of view, excipient carriers which are suitable to convert liquids into a solid…
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A new wheat-free mannitol grade for direct compression is now available with similar direct compression tableting properties to complementary PEARLITOL® SD mannitol grades, enabling high productivity direct compression tableting, a key manufacturing process for nutraceutical supplement companies.…
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This chapter describes the application of lactose as excipient in the pharmaceutical industry. About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of the biggest pharmaceutical excipients. Lactose can have several functions in a dosage form: as a filler to…
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Particle size distribution (PSD) variability in excipients may cause unacceptable prolongation of mixing time needed to achieve blend homogeneity. Therefore, it is vital to modulate mixing through real-time monitoring of PSD variability. Notwithstanding the criticality of PSD variability, real-time…
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