Pharma Excipients

Sugar Alcohols

Mannitol

Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction. Other widely known polyols are xylitol and sorbitol. Mannitol and sorbitol are isomers, differing only in the orientation of the hydroxyl group on carbon two.  The physical properties of mannitol make it…
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Freeze/thaw of IGG solutions

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at −20 °C for 20  h five times (interrupted by freeze/thaw).…
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Creating Value with Tailored ODT Solutions

Increasing patient adherence to medication regimens remains a top priority in the pharmaceutical industry. Simultaneously, consumers/patients are looking for dosage forms that are easy to take and that will not disrupt their everyday “on the go” lifestyle. Orally disintegrating tablets (ODTs) can…
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