Disintegrant / Superdisintergrant

The principal method of drug delivery is by oral solid doses, the production of which often necessitates multiple post-crystallization unit operations to ensure content uniformity and/or enhance bioavailability. As an alternative to conventional dose production methods, applications of additive…
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It is of great importance to get a deeper understanding of the binding behaviour and functionality of different types of dry binders, since dry binders are crucial to ensure appropriate properties of dry granules and tablets. Based on previous studies, the most effective dry binders of chemically…
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What is an orally disintegrating dosage form? An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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13. September 2018 Orodispersible films (ODFs) provide high application comfort due to rapid disintegration in the oral cavity. They increasingly found the approval of pharmaceutical research and development and were added to the European Pharmacopeia in 2012. The European Pharmacopeia explicitly…
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30. July 2018 Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-loaden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs. Drug nanoparticles are…
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15. June 2018 This study explores the influence of different synthesis methods and drying conditions in the preparation of sodium alginate-derivate xerogels presenting interesting disintegrant functionalities. Xerogels containing alginic acid (AA) or calcium alginate…
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