Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
PROSOLV® RX 90 – Ready-to-Use, High Functionality Excipient Composite for Direct Compression…
Streamline Your R&D and Production
Introduction
The health science industry faces a wide variety of challenges including increased pressure to:
Reduce costs
Accelerate time to market
Improve product performance
Cope with high demands and tight capacities
Utilize modern…
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Twenty grams in two weeks: Material sparing tablet development of direct compression formulations…
Abstract
Material-sparing tablet development (MSTD) describes an approach to tablet formulation development that uses the active pharmaceutical ingredient's (API) material properties to guide formulation design. The work presented here expands on this methodology and demonstrates its application…
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Taste Masking of Orodispersible Films: A Case Study in Palatability Optimization
It's all about the taste when David Tisi from Senopsys writes an article and we are happy to share his view on "Taste Masking of Orodispesible Films" with you in this article.
Orodispersible films (ODFs) are strips of water-soluble polymer matrices which contain an active ingredient that dissolves…
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Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Abstract
Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Results: Processing parameters, specifically granulation temperature and screw speed, were systematically…
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Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality…
Abstract
Aim
The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD.
Materials and Methods
The solvent casting method was used to formulate fast dissolving thin strips. The drug (Desvenlafaxine HCl), polymer
(pullulan), super…
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Dissolve Pain in Seconds: The Advantage of F-MELT®in Lornoxicam Fast Disintegrating Tablets
Introduction
Revolutionizing Pain Relief for Rheumatoid Arthritis (RA)
Lornoxicam, a potent NSAID, is widely used for rapid pain relief in rheumatoid arthritis. However, its poor water solubility (BCS II) and bitter taste have historically limited its effectiveness in fast disintegrating tablet…
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Recent developments in nanofiber-based fast-disintegrating drug delivery systems
Abstract
Introduction
Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug release by disintegrating rapidly in biological fluids or upon…
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A novel orodispersible film load with dual-coated sustained-release microparticles for pediatric…
Abstract
Orodispersible films (ODFs), easy to administer, flexible in dosage, and free of choking and aspiration risks, have drawn widespread attention as pediatric formulations. However, it is a great challenge to endow ODFs with sustained release due to their fast disintegration. Herein, we…
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Development and optimization of lyophilized dry emulsion tablet for improved oral delivery of…
Abstract
Ivermectin (IVM) is a widely used antiparasitic agent and has been repurposed for the treatment of COVID-19. However, its poor water solubility and low bioavailability present significant challenges, often requiring large doses for therapeutic effectiveness. This poses a burden on…
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Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression
Abstract
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
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