Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are…
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Liquisolids: A Modernistic approach in Drug Delivery System
Abstract
Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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The Role of BARETab Nutra DS in Direct Tablet Compression Method
BARETab Nutra DS is a novel Co-Processed excipients which is a combination of three Pharmacopeial excipients made by Co-Processing Technology. BARETab Nutra DS contains Dibasic Calcium Phosphate Anhydrous (Filler), Microcrystalline Cellulose (Binder) and Crosscarmellose Sodium (Disintegrant).…
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Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation…
Abstract
The mechanism governing pharmaceutical tablet disintegration is far from fully understood. Despite the importance of controlling a formulation's disintegration process to maximize the active pharmaceutical ingredient's bioavailability and ensure predictable and consistent release…
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SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.
SEPITRAP™ is both a solid solubilizer and a compression agent.…
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation – In vitro…
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate to severe depression. MTZ is classified as a BCS class II…
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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We…
Abstract
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful…
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Advancing oral drug delivery: The science of fast dissolving tablets (FDTs)
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially for patients with difficulties in swallowing. Fast Dissolving Tablets (FDTs) have emerged as a…
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Cushion-coated pellets for tableting without external excipients
Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing and compliance advantages over pellet-filled capsules. However, compaction may negatively affect the release control mechanism of pellets, and subunits may not be readily available after intake. Application of a…
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Research on classification of natural plant products and critical factors affecting tablet…
Abstract
The complex physical properties of natural plant products (NPPs) greatly influence the disintegration of NPP tablets, and the evaluation of their disintegration properties is generally overlooked. To solve this problem, the study aimed to reveal the disintegration behavior of NPP tablets…
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