Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Use of Liquid Solid Technique for Development and Evaluation Study of Nifedipine Tablets to Enhance…
Abstract
Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique.
Materials and Methods: The drug's solubility in various liquid carriers has been examined, out of which drug shows maximum solubility in PEG 400 which acts…
Read More...
Read More...
Evaluation of AaltoCell as a filler for tablets compressed from high-shear wet granulated…
Abstract
Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose, which is obtained by treating αcellulose with mineral acids. Ever since the first microcrystalline cellulose was commercialized, different grades of microcrystalline cellulose have widely been used in the…
Read More...
Read More...
Formulation and Evaluation Oral Dispersible Tablets of Vibegron
Abstract
In the present work, taste masking of Vibegron was carried out by using strong cation exchange resin tulsion 344. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant.…
Read More...
Read More...
High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and…
Abstract
Favipiravir, a high dose antiviral drug effective for oral treatment for COVID-19, with poor water solubility is formulated using a simple, low-cost melt coating and granulation methodology. High-dose (82.5 % w/w API) tablets (600 mg and 800 mg) with desired release profiles are…
Read More...
Read More...
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan
Abstract
Purpose
Heart failure, a progressive cardiovascular disorder, significantly affects patient morbidity and mortality. Valsartan, an angiotensin II receptor antagonist, is widely used to mitigate the effects of heart failure, but its oral administration faces challenges such as poor…
Read More...
Read More...
Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects
Abstract
Tablet coating with aqueous solvents represents a well-established environmentally sustainable alternative to coatings based on organic solvents. However, this practice requires a careful evaluation of potential quality issues, such as increased porosity and crack formation stemming from…
Read More...
Read More...
Analysis of Powder Properties of Pharmaceutical Excipients Using a Constant-Volume Shear Tester
Abstract
Powders used in pharmaceuticals require good flowability. The angle of repose and compressibility index are often used to measure the flowability of pharmaceutical powders. However, confirming the relationship between external forces and flowability for smooth powder handling is necessary.…
Read More...
Read More...
Mastering the Softgel Encapsulation Process: A Deep Dive into Precision Manufacturing
Softgel capsules are a cornerstone of modern pharmaceutical and nutraceutical industries, offering consumers a seamless, easy-to-swallow solution that enhances bioavailability and ensures precise dosing. This article will examine the intricate processes involved in softgel encapsulation,…
Read More...
Read More...
Simultaneous prediction of the API concentration and mass gain of film coated tablets using…
Abstract
This study investigates the simultaneous prediction of active pharmaceutical ingredient (API) concentration and mass gain in film-coated tablets using Partial Least Squares (PLS) regression combined with three data fusion (DF) techniques: Low-Level (LLDF), Mid-Level (MLDF), and…
Read More...
Read More...
Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties
Abstract
Magnesium stearate (MgSt) is a common tablet lubricant. As variations in MgSt properties are known to influence tablet attributes, the impact of MgSt fatty acid composition, particularly the significance of the stearate and palmitate contents, and its effects on tablet properties…
Read More...
Read More...