Disintegrants and superdisintegrant excipients are essential components used in the pharmaceutical industry to enhance the dissolution and bioavailability of active pharmaceutical ingredients (APIs). These excipients facilitate the disintegration and rapid breakup of tablets or capsules, which ultimately increases their rate of absorption in the body.
Pharma Excipients
Disintegrant / Superdisintergrant
Improvement of Bioavailability of Sildenafil Citrate Through Taste Masked Orodispersible Film for…
The oral bioavailability of sildenafil citrate is approximately 43%, primarily limited by the low aqueous solubility and first-pass effect. Considering the drug properties and biopharmaceutical considerations, this study aimed to develop an immediate release, taste masked orodispersible film (ODF)…
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Paediatric excipient risk assessment (PERA) tool and application for selecting appropriate…
Abstract
It is necessary to use a scientifically sound process for excipient risk evaluation, selection, and management in order to develop paediatric medicinal products that are both safe and effective. The “Paediatric Excipient Risk Assessment (PERA)” framework, which proposes a comprehensive…
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Tailored Sticky Solutions: 3D-Printed Miconazole Buccal Films for Pediatric Oral Candidiasis
In this research, 3D-printed antifungal buccal films (BFs) were manufactured as a potential alternative to commercially available antifungal oral gels addressing key considerations such as ease of manufacturing, convenience of administration, enhanced drug efficacy and suitability of paediatric…
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Superdisintegrants and their working mechanisms- by DFE Pharma
Superdisintegrants and their working mechanisms
Disintegrants and superdisintegrants are well-known excipients that are used in the formulation of oral dosage forms. They promote disintegration of tablets and capsule slugs when placed in an aqueous environment. Disintegration is the process of…
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Comparative Study of Spray-Drying and Freeze-Drying Techniques for Increasing Fenofibrate’s…
Abstract
Background: Fenofibrate (FF) is a BCS class II compound whose poor solubility poses challenges in drug delivery and bioavailability. Solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged as a promising solution to address these issues. These systems are aimed at…
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Exploring Vacuum Compression Molding as a Preparation Method for Flexible-Dose Pediatric…
Abstract
In recent years, solid dosage forms have gained interest in pediatric therapy because they can provide valuable benefits in terms of dose accuracy and stability. Particularly for orodispersible films (ODFs), the literature evidences increased acceptability and dose flexibility. Among the…
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Functionality of wet-granulated disintegrant in comparison to directly incorporated disintegrant in…
Tablet disintegration is crucial for drug release and subsequent systemic absorption. Although factors affecting the disintegrant’s functionality have been extensively studied, the impact of wet granulation on the performance of disintegrants in a poorly water-soluble matrix has received much less…
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Development and Assessment of Orally Disintegrating Tablet Containing Montelucast Sodium
Abstract
Montelukast sodium is widely used in treatment of asthma and other allergic disorders. The Montelukast sodium is a water insoluble drug but need quick action. So we planned a mouth dissolving tablet of Montelukast sodium. Further we evaluated functionality of co-processed super…
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Risk-Based Approach for Defining Retest Dates for Active Pharmaceutical Ingredients and Excipients
Abstract
Drug substances and excipients must be stored in recommended storage conditions and should comply with their specifications during the retest period for their use in the manufacture of drug products. The ICH (International Council for Harmonization of Technical Requirements for…
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Flexible modelling of the dissolution performance of directly compressed tablets
In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound, Disintegrated, and Dissolved) to describe the state of each particle…
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