Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Applications of Polysorbates – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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Combining in vitro, in vivo, and in silico approaches to evaluate the effect of serotonergic-based…
Abstract
Psoriasis, a chronic inflammatory skin disease, poses a significant burden on patients’ quality of life and healthcare systems. While mild-to-moderate cases are treated topically, usually combined with phototherapy, severe cases require systemic treatment with immunosuppressants, retinoids…
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Alteration of gel point of poloxamer 338 induced by pharmaceutical actives and excipients
Abstract
Poloxamer 338 is used as versatile thermo-responsive gelling agent in topical and sub-cutaneous applications. Due to application specific needs a gel point below body or even below room temperature is required. The influence of inorganic salts and active pharmaceutical ingredients (APIs)…
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Decades of expertise in the field of application technology – The Product Development (PD)…
IOI Oleo GmbH is known for its high-quality oleochemical specialities and the technical advice it provides on the use of its products. Thanks to its diversity and longstanding reliability, the product portfolio is used in the pharmaceutical, care, nutrition and technical applications sectors. The…
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Contemplating Novel W/O Emulsion Based Gel for Anti-Psoriatic Activity of Tofacitinib in…
Abstract
Tyrosine kinase inhibitors like tofacitinib (TCB), are excellent examples of small molecular compounds that have demonstrated success in treating psoriasis. The current study aims to improve the efficacy of TCB and reduce its systemic adverse effects by developing a topical w/o emulgel…
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Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes
Abstract
The skin, being the largest organ of the human body, serves as the primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead to the generation of reactive oxygen species…
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Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical…
ABSTRACT
Background
EsoCap is a thin mucoadhesive film designed to target the oesophageal mucosa. The device loaded with mometasone furoate (ESO-101) is under investigation for the treatment of eosinophilic oesophagitis (EoE).
Aims
To evaluate the efficacy, safety and tolerability of…
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Aestheticizing the Self-Stabilized Pickering Emulsion of Capecitabine: Harnessing Polysarcosine…
Abstract
This study focuses on the formulation, optimization, and characterization of a water-in-oil (W/O) Pickering emulsion (PE) containing capecitabine (CAP), which is self-stabilized using polysarcosine (Psar) nanoparticles (NPs), to create a topical treatment for squamous cell carcinoma…
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Topical Application of Dipyridamole and Roflumilast Combination Nanoparticles Loaded Nanoemulgel for…
Abstract
Background: Phosphodiesterase-4 is an enzyme that regulates immune responses and contributes to the development of psoriasis. Dipyridamole and roflumilast function as phosphodiesterase-4 inhibitors, reducing pro-inflammatory cytokine expression. The aim was to evaluate the anti-psoriatic…
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Development and Optimization of Transferosomal Gel for Efficient Topical Delivery of Berberine…
Background
Berberine is an isoquinoline alkaloid with potent anti-inflammatory effects. However, its therapeutic efficacy is often restricted by its poor solubility, absorption, and permeability, especially in topical applications. Transferosomes are elastic vesicular carriers with high skin…
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