Pharma Excipients
Emulsifier
Solid lipid discs from water-in-oil emulsion as controlled release delivery systems of highly…
Abstract
Solid lipid systems (SLSs) are widely employed to control the release of highly hydrophilic drugs, and they are, in general, obtained by solubilizing or suspending the drug within melted lipid excipients. This work proposes an advantageous strategy to modulate the drug release of a…
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Pickering emulsion gels stabilized by protein and polysaccharide-based particles: A review of…
Abstract
With a far longer stability than traditional emulsions, Pickering emulsion gels (PKEGs)—stabilized by solid particles—have proven highly efficient in a range of applications during recent years. Particles based on proteins or polysaccharides with distinctive amphiphilic structure are…
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Phospholipid-Based Delivery Systems: Phospholipids as Excipients in Advanced Veterinary Drugs
Abstract
Phospholipids are excellent natural excipients for veterinary applications. They are essential components of the membrane of any biological cell. They accommodate membrane proteins, creating membranes with highly selective permeability properties necessary for cell survival. Thanks to this…
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Development and optimization of lyophilized dry emulsion tablet for improved oral delivery of…
Abstract
Ivermectin (IVM) is a widely used antiparasitic agent and has been repurposed for the treatment of COVID-19. However, its poor water solubility and low bioavailability present significant challenges, often requiring large doses for therapeutic effectiveness. This poses a burden on…
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Development of a droplet size prediction tool for manufacture of emulsion creams
Abstract
A practical computational tool was designed to estimate droplet size distributions in process equipment for ointment manufacturing, thereby providing guidance in selecting optimal equipment operating parameters for producing emulsions with desired characteristics. For simplicity and…
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Acyl chitosan based self-nanoemulsifying drug delivery system of lipophilic drug with enhanced oral…
Abstract
This study developed a mucoadhesive self-nano emulsifying drug delivery system (SNEDDS) with synthesized acyl chitosan coating for enhancing oral bioavailability and drug retention of Amphotericin B (AB) which is conventionally administered parenterally owing to its poor bioavailability.…
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Applications of Macrogol Lauryl Ether (Polidocanol) – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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AQUAPOL® SF-1 – Thickening and Gelling Agent – by Vikram Thermo
AQUAPOL
Thickening and gelling agent
The AQUAPOL line of “Acrylates polymers” is a synthetic high molecular weight cross-linked water-soluble polymer of acrylic acid. The cosmetic, pharmaceutical, and home industries all use it extensively. It comes as a liquid or powder and is soluble in water,…
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Physical Isolation Strategy in Multi-Layer Self-Nanoemulsifying Pellets: Improving Dissolution and…
Abstract
Background and Purpose
Liquid self-nanoemulsifying drug delivery systems (SNEDDS) face challenges related to stability, handling, and storage. In particular, lipophilic and unstable drugs, such as ramipril (RMP) and thymoquinone (THQ), face challenges in oral administration due to poor…
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AQbD-Based UPLC-ELSD Method for Quantifying Medium Chain Triglycerides in Labrafac™ WL 1349 for…
Abstract
In response to recent regulatory guidelines, including ICH (International Council for Harmonisation) Q2 (R2) and Q14, we developed a UPLC-ELSD method to quantify Medium-Chain Triglycerides (MCTs) in Labrafac™ WL 1349 for nanoemulsion applications. This procedure, crafted using Analytical…
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