Emulsifier

Abstract Solid lipid systems (SLSs) are widely employed to control the release of highly hydrophilic drugs, and they are, in general, obtained by solubilizing or suspending the drug within melted lipid excipients. This work proposes an advantageous strategy to modulate the drug release of a…
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Abstract With a far longer stability than traditional emulsions, Pickering emulsion gels (PKEGs)—stabilized by solid particles—have proven highly efficient in a range of applications during recent years. Particles based on proteins or polysaccharides with distinctive amphiphilic structure are…
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Abstract Phospholipids are excellent natural excipients for veterinary applications. They are essential components of the membrane of any biological cell. They accommodate membrane proteins, creating membranes with highly selective permeability properties necessary for cell survival. Thanks to this…
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Abstract Ivermectin (IVM) is a widely used antiparasitic agent and has been repurposed for the treatment of COVID-19. However, its poor water solubility and low bioavailability present significant challenges, often requiring large doses for therapeutic effectiveness. This poses a burden on…
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Abstract A practical computational tool was designed to estimate droplet size distributions in process equipment for ointment manufacturing, thereby providing guidance in selecting optimal equipment operating parameters for producing emulsions with desired characteristics. For simplicity and…
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Abstract This study developed a mucoadhesive self-nano emulsifying drug delivery system (SNEDDS) with synthesized acyl chitosan coating for enhancing oral bioavailability and drug retention of Amphotericin B (AB) which is conventionally administered parenterally owing to its poor bioavailability.…
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KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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AQUAPOL Thickening and gelling agent The AQUAPOL line of “Acrylates polymers” is a synthetic high molecular weight cross-linked water-soluble polymer of acrylic acid. The cosmetic, pharmaceutical, and home industries all use it extensively. It comes as a liquid or powder and is soluble in water,…
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Abstract Background and Purpose Liquid self-nanoemulsifying drug delivery systems (SNEDDS) face challenges related to stability, handling, and storage. In particular, lipophilic and unstable drugs, such as ramipril (RMP) and thymoquinone (THQ), face challenges in oral administration due to poor…
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Abstract In response to recent regulatory guidelines, including ICH (International Council for Harmonisation) Q2 (R2) and Q14, we developed a UPLC-ELSD method to quantify Medium-Chain Triglycerides (MCTs) in Labrafac™ WL 1349 for nanoemulsion applications. This procedure, crafted using Analytical…
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