Pharma Excipients

Sweeteners

Sweetener Introduction

What Are Sweeteners?

Relative Sweetness: How Sweet is Sweet?

News on Sweeteners

Freeze/thaw of IGG solutions

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at −20 °C for 20  h five times (interrupted by freeze/thaw).…
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Relative Sweetness: How Sweet Is Sweet?

Broadly speaking, there are three categories of sweeteners – nutritive, sugar alcohols, and high intensity. Sweetener selection is informed by technical, regulatory and clinical considerations as described in the Introduction to Sweeteners. A formulator has many choices in selecting a sweetener, but…
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