Filler excipients are used to increase the volume of the material to enable easier processing of the ingredients and make it into a size suitable for consumption. Moreover, they can stabilize the product and help during manufacturing.
Pharma Excipients
Filler
Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these…
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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during…
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Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization aid was investigated. Furthermore, the impact of cations on extrusion-spheronization (ES) of CCS was studied and different grades of CCS were tested.…
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Unveiling the Mystery of Soft Gelatin Capsules
Soft Gelatin Capsules (SGCs), commonly known as softgels, have transformed drug delivery since their invention. Despite their 19th-century origins, their widespread adoption only began in the 20th century, thanks to technological advancements by Robert Pauli Scherer. This innovation revolutionized…
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The effect of material properties and process parameters on die filling at varying throughputs: A…
Abstract
When tablets are manufactured on a rotary tablet press and the throughput is increased, it leads to changes in powder dynamics during die filling due to formulation characteristics and changing powder flow in the feed frame. This may result, a.o. in increased tablet weight variability,…
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The influence of milling of ribbons on selected granule quality attributes and carvedilol release…
Abstract
Roller compaction is gaining importance in the pharmaceutical industry. This study evaluates the impact of ribbon milling conditions on properties of granules and compression mixtures and on drug release from hypromellose-based matrix tablets prepared with two different fillers. In the…
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Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs) have been developed and successfully implemented in…
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Lessons to learn for 3D printing of drug products by semisolid extrusion (SSE)
Abstract
Semisolid extrusion (SSE) 3DP technology is emerging due to its simplicity and potential for on-site manufacturing of personalized drug products with tailored functionality (dose, release profile), as well as recognizability (size, shape, color). However, even a minor change in the…
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Design of easily swallowable xerogel pill with enough physical strength through hardening-process…
The xerogel pill has been developed as a novel dosage form with dose-adjusting and swallow-assisting functions by using drop freeze-drying (DFD) technique. It was double-structured small sphere composed of an inner drug core and an outer dried-gel layer, however, had problem of insufficient physical…
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Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
Abstract
The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the…
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