Filler

Abstract Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to…
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Introduction: Punch sticking is a common phenomenon in tablet manufacturing, often leading to tablet defects and compromise product quality. A thorough understanding of the sticking mechanism is essential to optimize the tablet production process. The aim of this study was to investigate the…
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Abstract This study aims to investigate the effects of the relative humidity and formulation ratio on the hygroscopicity, tableting performance, and physical stability of polyols (mannitol and xylitol) as fillers in chewable tablets. To address the issues of hygroscopicity and sticking during…
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Abstract Nanocellulose, a sub-micron cellulose powder, was investigated as a potential filler excipient to enhance the tabletability of acetaminophen (APAP). Due to its high specific surface area, nanocellulose was expected to outperform the tabletability enhancement provided by microcrystalline…
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Abstract This study examines the influence of crospovidone (CP) manufacturer variability on the dissolution profiles of hydrochlorothiazide (HCTZ) tablets. Four CP batches from different manufacturers were characterized using pharmacopeial and physicochemical tests, including infrared absorption,…
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Abstract Three-dimensional printing is promising in the pharmaceutical industry for personalized medicine, on-demand production, tailored drug loading, etc. Pressure-assisted microsyringe (PAM) printing is popular due to its low cost, simple operation, and compatibility with heat-sensitive drugs…
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Coprocessed excipients in the pharmaceutical industry are substances created by combining two or more individual excipients through various processing techniques to physically modify their properties without significant chemical change. At BASF, our coprocessed excipients have been strategically…
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Abstract The preparation of a solid dosage form containing bacteriophages, which meets pharmaceutical requirements and ensures long-term stability of the phage effect, is significant for implementing phage therapy in practice. A commonly used method for processing phages into a solid form is…
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Abstract Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose, which is obtained by treating αcellulose with mineral acids. Ever since the first microcrystalline cellulose was commercialized, different grades of microcrystalline cellulose have widely been used in the…
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Abstract Previous research has shown that controlled release (CR) formulations with hydrox- ypropyl methylcellulose (HPMC) as hydrophilic matrix former produced via twin-screw wet granulation (TSWG) yield granules with an inhomogeneous active pharmaceutical ingredient (API) distribution (Denduyver…
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