Pharma Excipients

Filler

The rise of independent excipients

The pressure to innovate faster than their competitors has drug formulators exploring new ways to optimise manufacturing processes Article in manufacturingchemist.com Continuous manufacturing, for example, has evolved at a relatively fast pace, leaving drug manufacturers feeling equally challenged…
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Towards a better understanding of dry binder functionality

It is of great importance to get a deeper understanding of the binding behaviour and functionality of different types of dry binders, since dry binders are crucial to ensure appropriate properties of dry granules and tablets. Based on previous studies, the most effective dry binders of chemically…
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Use of Mannitol as a Filler in Wet Granulation

A study was conducted to evaluate mannitol as a filler along with microcrystalline cellulose (MCC) in wet granulated tablet formulation, in situations in which lactose cannot be included in the formulation because of chemical incompatibility with the active drug. A two-level full factorial design…
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Effect of Binder Attributes on Granule Growth and Densification

The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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