Filler

Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights into product performance, complementing traditional methods…
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Abstract Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in the fines fraction (<150 µm) was…
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The Application of Fillers and Binders in Solid Dosage Formulation Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties that offer greater flowability and compressibility which…
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Discover our, Merck, new Parteck® LM Excipient System: This exceptional product offers excellent flow properties, ensuring reliable dosing in both batch and continuous processes. With its consistent dosing and robust, constant mixing times, Parteck® LM Excipient System supports a consistent…
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Abstract Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit…
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In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression…
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Microcrystalline Cellulose MICROCEL® Microcrystalline cellulose is used as a filler/binder as well as a fiber source in various oral dosage forms in both pharmaceutical and nutraceutical applications. Microcrystalline cellulose has a long history of use in pharmaceutical dosage form and has had a…
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PURPOSE Mini tablets are a multiple unit dosage form with a size of less than 3.0 mm in diameter with great flexibility to deliver appropriate doses to the pediatric age group. They can be given in different numbers, according to dosage requirements, with no special prerequisite of formulating age…
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Abstract Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of daily life. Conductive polymers (CPs) are an emerging group of polymers that possess metal-like…
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Abstract The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. The tableting machine was equipped with a thermally controlled die to mimic the heat…
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