Filler

Abstract Material-sparing tablet development (MSTD) describes an approach to tablet formulation development that uses the active pharmaceutical ingredient's (API) material properties to guide formulation design. The work presented here expands on this methodology and demonstrates its application…
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Abstract Tablets are subjected to collisions during processing and handling which can result in defects and even failed batches at commercial scale. This study investigated the influence of composition and tablet shape on the tablet integrity under simulated stressed settings. Tablet formulations…
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Magnesium Carbonate is not only a reliable Magnesium source for food supplements, but also an exceptionally versatile excipient in pharmaceutical formulations. Dr. Paul Lohmann® offers high-purity Magnesium Carbonate tailored to meet your functional and regulatory needs – from direct compression to…
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Abstract Purpose This study aimed to develop immediate-release Quetiapine Fumarate (QTF) tablets using twin-screw melt granulation (TSMG), a solvent-free and efficient granulation method, and compare their dissolution profiles with the marketed product. Methods QTF tablets were formulated using…
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Abstract Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RD/DG process parameters and subsequently binder compositions by employing…
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This poster was presented at the ECP 2025 in Porto A proof of concept with wet extrusion Introduction Veterinary soft chews are gaining interest among oral dosage forms for companion animals as they provide good acceptance for the pet and are easy to administrate by the pet owner,…
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This poster was presented at the ECP 2025 in Porto Introduction The agglomeration of fine powders during the twin-screw melt granulation (TSMG) occurs due to the softening or melting of thermal binders, consolidation by kneading (applied mechanical forces) and cooling to room temperature along…
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Abstract Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
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The mixing of ductile lubricant particles is known to have several negative effects on tablet properties, such as decreased hardness and delayed disintegration. This study investigated the usefulness of a mixing system using an intensive mixer with a rotating mixing vessel (EIRICH Intensive Mixer)…
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Abstract Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to…
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