Pharma Excipients
Filler
The rise of independent excipients
The pressure to innovate faster than their competitors has drug formulators exploring new ways to optimise manufacturing processes
Article in manufacturingchemist.com
Continuous manufacturing, for example, has evolved at a relatively fast pace, leaving drug manufacturers feeling equally challenged…
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Roller compaction: Improving the homogeneity of ribbon properties along the roller width
A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The porosity distribution resulting from the applied stress, was…
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Dropwise Additive Manufacturing of Pharmaceutical Products using Particle Suspensions
The principal method of drug delivery is by oral solid doses, the production of which often necessitates multiple post-crystallization unit operations to ensure content uniformity and/or enhance bioavailability. As an alternative to conventional dose production methods, applications of additive…
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Evaluation of the application of cashew gum as an excipient to produce tablets
Cashew gum is extracted from the exudate of the giant cashew tree (Anacardium occidentale L.). The objective of this work was to study the extraction and purification of cashew gum through experiments to characterize its structures and physicochemical and thermal properties, and to evaluate its use…
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Methodology to estimate the break force of pharmaceutical tablets with curved faces under…
This paper develops a methodology to estimate the break force of curved faced tablets under diametrical compression. Common excipients used in pharmaceutical tablet formulations, including microcrystalline cellulose, calcium phosphate and mannitol as well as their mixtures were characterised.…
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Towards a better understanding of dry binder functionality
It is of great importance to get a deeper understanding of the binding behaviour and functionality of different types of dry binders, since dry binders are crucial to ensure appropriate properties of dry granules and tablets. Based on previous studies, the most effective dry binders of chemically…
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Use of Mannitol as a Filler in Wet Granulation
A study was conducted to evaluate mannitol as a filler along with microcrystalline cellulose (MCC) in wet granulated tablet formulation, in situations in which lactose cannot be included in the formulation because of chemical incompatibility with the active drug. A two-level full factorial design…
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Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet…
This study focussed on investigating the coupling of continuous manufacturing of drug substance and continuous manufacture of drug product. An important step in such an integrated end-to-end continuous manufacturing was envisioned by dosing the API as suspension into a twin-screw wet granulation…
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Effect of Binder Attributes on Granule Growth and Densification
The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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Orally disintegrating dosage forms
What is an orally disintegrating dosage form?
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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