Discovered in 1955, the excipient microcrystalline cellulose is the most commonly used binder on the pharmaceutical market. It’s popularity comes from its versatility and a huge range of applications. It can bulk, disintegrate, bind, and lubricate. It enhances stability and extends drug release. As a natural, fibre-rich component, it’s nontoxic and chewable. It’s also a favourite among dissolvable drug manufacturers. It’s carved a space for itself as an excipient in both the supplement industry and the potent drug delivery niche. Its scope is not limited to capsules and tablets. It’s used in medicated gels, as well.
Pharma Excipients
Microcrystalline Cellulose
A novel orodispersible film load with dual-coated sustained-release microparticles for pediatric…
Abstract
Orodispersible films (ODFs), easy to administer, flexible in dosage, and free of choking and aspiration risks, have drawn widespread attention as pediatric formulations. However, it is a great challenge to endow ODFs with sustained release due to their fast disintegration. Herein, we…
Read More...
Read More...
Impact of pharmaceutical tablet properties on optical porosimetry performance
Abstract
The porosity of a pharmaceutical tablet influences liquid transport, disintegration and dissolution, rendering its monitoring and control crucial for quality by design. Optical porosimetry, a non-destructive process analytical technology (PAT), combines gas in scattering media absorption…
Read More...
Read More...
Development and optimization of mucoadhesive sustained-release chlorothiazide pellets for improved…
Abstract
Chlorothiazide (CTZ), a widely used thiazide diuretic, exhibits poor and variable oral bioavailability due to site-specific absorption and carrier-mediated saturable transport in the upper gastrointestinal tract. This study aimed to develop mucoadhesive controlled-release pellets of CTZ to…
Read More...
Read More...
Spray Dried Lubricants Offering Enhanced Flowability
Introduction
There are several approaches in order to develop tablet formulations. On the one hand, high functionality excipients that follow the concept “API+1” offer many advantages like easier handling, higher compactability and they combine synergistic effects. In addition, they eliminate the…
Read More...
Read More...
Influence of material and process parameters on the correction factor Kp in roller compaction…
Abstract
It is widely believed that compaction simulators can replicate the uniaxial compression process of a roller compactor. The correction factor (Kp) is a parameter used to adjust a mathematical model for compaction simulation to obtain the same product relative density, therefore accounting…
Read More...
Read More...
Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms…
Abstract
The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
Read More...
Read More...
An iterative process and mixture design approach for dry granulated ternary blends of filler-binders
Abstract
Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RD/DG process parameters and subsequently binder compositions by employing…
Read More...
Read More...
Isomalt as PVP-Binder Replacement in High-Shear Wet Granulation for Tablet Preparation – ECP…
This poster was presented at the ECP 2025 in Porto
Introduction
Tablets are one of the most widely used oral dosage forms for oral delivery in the pharmaceutical and nutraceutical industries.
If the drug dose per tablet is high and the formulation cannot ensure direct compression…
Read More...
Read More...
Effect of microcrystalline cellulose (MCC) grade on the properties of twin-screw melt granulated…
This poster was presented at the ECP 2025 in Porto
Introduction
The agglomeration of fine powders during the twin-screw melt granulation (TSMG) occurs due to the softening or melting of thermal binders, consolidation by kneading (applied mechanical forces) and cooling to room temperature along…
Read More...
Read More...
Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression
Abstract
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
Read More...
Read More...