Discovered in 1955, the excipient microcrystalline cellulose is the most commonly used binder on the pharmaceutical market. It’s popularity comes from its versatility and a huge range of applications. It can bulk, disintegrate, bind, and lubricate. It enhances stability and extends drug release. As a natural, fibre-rich component, it’s nontoxic and chewable. It’s also a favourite among dissolvable drug manufacturers. It’s carved a space for itself as an excipient in both the supplement industry and the potent drug delivery niche. Its scope is not limited to capsules and tablets. It’s used in medicated gels, as well.
Pharma Excipients
Microcrystalline Cellulose
Advances in Taste-Masking Strategies for Pediatric Brain-Related Disease Treatments: Focus on…
Abstract
Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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Advancing medication compounding: Use of a pharmaceutical 3D printer to auto-fill minoxidil capsules…
Abstract
Compounding medications in pharmacies is a common practice for patients with prescriptions that are not available commercially, but it is a laborious and error-prone task. The incorporation of emerging technologies to prepare personalised medication, such as 3D printing, has been delayed…
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Particle-based investigation of excipients stability: the effect of storage conditions on moisture…
Abstract
Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for…
Abstract
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the…
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Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100
Abstract
Process Analytical Technology (PAT) plays a crucial role in the design of today’s manufacturing lines as continuous manufacturing becomes more important. Until now PAT tools to measure the ribbon solid fraction (SFribbon) in-line are not commonly used in roll compaction. The aim of this…
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Quantifying Crystallinity of Amlodipine Maleate in Amorphous Solid Dispersions Produced by Fluidized…
Abstract
One of the main concerns with formulations containing amorphous solid dispersions (ASDs) is their physical stability. Stability can be compromised if a formulation contains any residual crystallinity of an active pharmaceutical ingredient (API) that could act as seeds for further…
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A comparative study of two data-driven modeling approaches to predict drug release from ER matrix…
Abstract
The pharmaceutical industry is striving to develop innovative and promising tools, increasingly embracing new data-driven approaches, to understand, improve and accelerate the drug product development process. While extended release (ER) oral formulations offer a number of advantages,…
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Advancements in Omeprazole Formulations: From Technological Innovation to Release Strategies
Abstract
This chapter reviews data on 72 omeprazole (OME) formulations developed in the past 5 years. The types of OME formulations, the excipients and the methods are analyzed in depth. Data on 72 omeprazole (OME) formulations created over the last 5 years are reviewed in this chapter. A…
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Formulation Development and Evaluation of Brivaracetam Extended- Release Tablets by QbD Approach
Press Release
Abstract
This research article outlines a systematic and science-based approach to formulate extended-release tablets of brivaracetam (BRV) by means of quality by design (QbD) method. BRV, a potent antiepileptic drug, faces challenges due to its short half-life, necessitating…
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Patent on pharmaceutical compositions and methods for treating hyperhidrosis
The patent application US20240350420A1 focuses on pharmaceutical formulations and methods for treating conditions such as hyperhidrosis, which involves excessive sweating. The document details the development of modified-release compositions, specifically utilizing Pilocarpine HCl, a muscarinic…
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