Discovered in 1955, the excipient microcrystalline cellulose is the most commonly used binder on the pharmaceutical market. It’s popularity comes from its versatility and a huge range of applications. It can bulk, disintegrate, bind, and lubricate. It enhances stability and extends drug release. As a natural, fibre-rich component, it’s nontoxic and chewable. It’s also a favourite among dissolvable drug manufacturers. It’s carved a space for itself as an excipient in both the supplement industry and the potent drug delivery niche. Its scope is not limited to capsules and tablets. It’s used in medicated gels, as well.
Pharma Excipients
Microcrystalline Cellulose
Oral Gels as an Alternative to Liquid Pediatric Suspensions Compounded from Commercial Tablets
Abstract
The aim of the study was to propose pharmacy-compounded oral gels as a new and alternative dosage form that is attractive to children as having a better masking taste than syrups and reducing the risk of spilling. The application and physical properties of the gels prepared with cellulose…
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Design and development of Fujicalin-based axitinib liquisolid compacts for improved dissolution and…
Abstract
Poor dissolution of axitinib (AXT) limits its effectiveness through the oral route. The present study investigated, prospective of liquisolid (LS) technology to improve dissolution rate and oral bioavailability of AXT to treat renal cell carcinoma. LS compacts were fabricated with PEG…
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Examining particle size growth in twin screw granulation up to steady state with acoustic emissions
Abstract
The transient evolution of granules was studied to learn new details about the underlying mechanism for continuous wet granulation in a twin-screw extruder. Sieving and a new inline PAT for particle size development was used to gain these insights. The onset for steady state was…
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A Novel Approach of Formulation & Evaluation of Tablet in Capsule Device for GI Protection Pain…
Abstract
This research article presents a novel approach in the formulation and evaluation of a tablet in capsule device aimed at providing GI protection and effective pain management. Key aspects include the development of Aceclofenac Extended-Release tablets and Misoprostol Immediate Release…
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Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated…
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Rivaroxaban-Excipient Compatibility Studies For Advanced Drug Delivery Systems Development
Abstract
The main objective of the present study was to the preformulation studies were performed to know the physico-chemical and mechanical properties of Rivaroxaban for formulation development of ODTs. The drug-excipient compatibility studies were conducted to characterize the drug Rivaroxaban…
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Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride…
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems.…
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Continuous micro feeding and mixing of solid dosage forms under vibrational excitation
Abstract
Continuous manufacturing has intrigued many researchers in the pharmaceutical industry in the post-COVID-19 world. We experimentally studied the discharge characteristics of pharmaceutical excipients under vibrational excitation. The successful accurate dosing and filling of powders at…
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Further enhancement of the sustained-release properties and stability of direct compression gel…
Abstract
The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi Xi Qing®), prepared via wet granulation, discolor during long-term storage, and the process is less reproducible and more cumbersome. In this study, the direct compression (DC) method was used to prepare equivalent and…
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Biopharmaceutical studies of a novel sedative sublingual lozenge based on glycine and tryptophan: A…
Effective sedative drugs are in great demand due to increasing incidence of nervous disorders. The present work was aimed to develop a novel sublingual sedative drug based on glycine and L-tryptophan amino acids. Carbopol and different hydroxypropyl methylcellulose species were alternatively tested…
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