Organic Chemicals

MCC pellets under rheological investigation are ideal model spheres for studying powder behavior. In this study, we revisit the work...

Abstract Tablet strength is derived from particle interactions characterized by bonding area and bonding strength. These quantities should be considered...

Abstract Multiparticulate formulations based on pellets, granules or beads, could be advantageous for paediatrics, geriatrics and patients with swallowing difficulties....

Executive Summary: Formulating high-dose active pharmaceutical ingredients (APIs) often introduces severe technical hurdles, including tablet hardness, capping, and high compactibility....

Abstract The aim of this study was to assess to what extent a simulated trehalose monolayer can predict the minimum...

Abstract Tablet capping is a critical manufacturing defect whose early prediction is essential to prevent product failures and process interruptions....

Abstract The development of enteric multiparticulate systems requires precise control of coating architecture and release behavior to ensure consistent in...

Abstract Pediatric maintenance therapy for acute lymphoblastic leukemia requires prolonged daily administration of 6-mercaptopurine (6-MP), a drug characterized by a...

Abstract Co-processed excipients (CPEs) are widely used in direct compression formulations to improve powder flowability and the tensile strength of...

Abstract Background/Objectives: The development of multifaceted excipients is a requirement of the pharmaceutical industry. This study aimed to develop a...