Pharma Excipients
Viscocity Agent
A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric…
Abstract
TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability. However, micelles formulations are generally characterized by low…
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Kollidon® 90 Evo – A highly effective water soluble binder with low impurity profile
Join the evolution of the BASF PVP portfolio! Kollidon® 90 Evo combines outstanding purity and innovative packaging.
Kollidon® 90 Evo is a highly effective binder with exceptional purity
Very low impurity profile, e.g., 2-pyrrolidone, aldehydes and hydrazine
Broad range of applications…
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Medication Lubricants for Oral Delivery of Drugs: Oral Processing Reduces Thickness, Changes…
Abstract
Swallowing oral solid dosage forms is challenging for those who have medication swallowing difficulties, including patients with dysphagia. One option is to mix the drug (whole or crushed) with a thick vehicle (medication lubricant). Previous in vitro studies consistently suggest that…
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Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized…
Abstract
The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data matrix-generator software specifically focused on the healthcare…
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Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and…
Producing amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is favorable from an economic and ecological perspective but also limited to thermostable active pharmaceutical ingredients (APIs). A potential technology shift from spray-drying to hot-melt extrusion at later stages of drug…
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Rheology of amino-functionalized graphene oxide suspensions in hydrogels
This work investigates the effects of amino-functionalized graphene oxide (AFGO) suspensions on the rheological behavior of Carbopol® hydrogels at pHs 5, 7, and 9. The AFGO concentration and media pH were evaluated and related to the suspension's microstructure and rheology. Graphene oxide (GO)…
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Raw Materials – Practical Pharmaceutics Part 1
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality…
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Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
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Overcoming Challenges in Ophthalmic Formulations through Polymer Selection
Ophthalmic drugs are delivered to the eye to treat chronic diseases such as dry eye and acute conditions such as inflammation and infections.
The market for drugs administered to the eye is growing, in large part, due to our aging population and the increased prevalence of eye-related conditions…
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Transdermal delivery of acemetacin loaded microemulsions: preparation, characterization, in vitro –…
The goal of this study was to see if microemulsions might be used as a transdermal drug delivery system for acemetacin (ACM). Microemulsions containing isopropyl myristate, Tween 80, Transcutol HP, Labrafil M1944 CS, ethanol, and distilled water were used to create pseudo-ternary phase diagrams. In…
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