Pharma Excipients
Propylene Glycol
Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for…
Abstract
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the…
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Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the…
Abstract
Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within…
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50 Novel Drug Approvals by FDA in 2024 – What’s inside?
The FDA approved 50 novel drugs in 2024, marking another milestone year in pharmaceutical innovation. While various summaries have highlighted these approvals, the composition and presentation of these new drug products — encompassing APIs and excipients — are often less explored.
To address…
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Design and evaluation of solid self-nanoemulsifying drug delivery systems of cyclosporine developed…
Abstract
Cyclosporine (CYC) is a drug that belongs to the BCS class II category. This study was designed to develop novel solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for cyclosporine (CYC), using chitosan–EDTA microparticles. Such microparticles are known to exhibit superior…
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The composition of Drugs going off-patent in the upcoming years
As a follow up on the article 𝐖𝐡𝐢𝐜𝐡 𝐝𝐫𝐮𝐠𝐬 𝐰𝐢𝐥𝐥 𝐥𝐨𝐬𝐞 𝐩𝐚𝐭𝐞𝐧𝐭𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐜𝐨𝐦𝐢𝐧𝐠 𝐲𝐞𝐚𝐫𝐬? by Joanna Sadowska, PhD, EMBA in which includes over 30 products going off-patent from 2025 to 2037 we pulled together the dosage form and composition of these products. Please note that the composition may vary in…
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Optimization of nano-structured lipid carriers for enhanced salbutamol delivery via buccal…
Abstract
Salbutamol sulphate (SS) is a widely prescribed β2 agonist for different respiratory disorders. However, its short plasma half-life and poor oral bioavailability strongly limit its compliance. This study targeted formulating SS in nanostructured lipid carriers (SS-NLCs) embedded in a…
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Enhancing oral bioavailability of dasatinib via supersaturable SNEDDS: Investigation of…
Abstract
Dasatinib (DASA), a potent second-generation multitarget kinase inhibitor marketed as Sprycel® (Tablet), is limited by poor oral bioavailability (14–24 %) and dose-related gastrointestinal side effects. A supersaturable self-nanoemulsifying drug delivery system (su-SNEDDS) designed to…
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An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis
Abstract
The intestinal mucus layer plays a crucial role in the systemic absorption of drugs. While penetration through this layer traditionally constitutes a pivotal phase in drug absorption, the approach for treating ulcerative colitis (UC) shifts towards facilitating the direct delivery of…
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Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based…
Abstract
Mesoporous silica offers an easy way to transform liquids into solids, due to their high loading capacity for liquid or dissolved active ingredients and the resulting enhanced dissolution properties. However, the compression of both unloaded and loaded mesoporous silica bulk material into…
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The Role of Coatings and Plasticizers Compatibility in Stability of Advanced Gastro-resistant…
The gastro-resistant behaviour of solid self-emulsifying drug delivery systems (S-SEDDS) represents a significant and innovative advancement in delivering poorly soluble drugs. Due to the complexity of these systems and the liquid nature of SEDDS, thorough investigation is essential. This study…
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