Pharma Excipients
Povidones
Preparation, Characterization, and Evaluation of a Novel Co-Processed Excipient as a Directly…
Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and characterize pregelatinized starch-polyvinylpyrrolidone (PGS-PVP)…
Read More...
Read More...
A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE…
Abstract
Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent…
Read More...
Read More...
Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin:…
Abstract
Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of a drug-containing core, a swellable/biodegradable polysaccharide inner layer and a gastroresistant outer film. High-methoxyl pectin was…
Read More...
Read More...
Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches…
Abstract
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end-user surveys have hindered their commercialization…
Read More...
Read More...
Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However, when focusing on protein and peptide transdermal delivery,…
Read More...
Read More...
The interplay of poorly soluble drugs in dissolution from amorphous solid dispersions
In recent years, the application of fixed dose combinations of antiretroviral drugs in HIV therapy has been established. Despite numerous therapeutic benefits, this approach poses several challenges for the formulation development especially when poorly soluble drugs are considered. Amorphous solid…
Read More...
Read More...
3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and…
Abstract
The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the…
Read More...
Read More...
Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic screening of excipients was conducted to determine the most…
Read More...
Read More...
Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on…
Read More...
Read More...
Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of…
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of…
Read More...
Read More...