Pharma Excipients
Povidones
Advances in Taste-Masking Strategies for Pediatric Brain-Related Disease Treatments: Focus on…
Abstract
Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for…
Abstract
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the…
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Unveiling the impact of preparation methods, matrix/carrier type selection and drug loading on the…
Abstract
Amorphous solid dispersions (ASDs) are widely recognized for their potential to enhance the solubility of poorly water-soluble drugs, with factors such as molecular mobility, intermolecular interactions, and storage conditions playing critical roles in their performance. However, the…
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“Green” technology of centrifugal fiber formation of solid dispersed systems of…
Abstract
This work reports on the first developed solid dispersed systems (SDSs) of nimesulide using technology of centrifugal fiber formation, which meets the principles of "green chemistry” and provides increased solubility of the active pharmaceutical ingredient (API).
Highlights…
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Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the…
Abstract
Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within…
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Pediatric Formulation Optimization Using a Rational Design: Exploring Amorphous Solid Dispersion…
Abstract
Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER), a powerful antifungal agent, is effective against various fungal infections, including Tinea capitis, which is…
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Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100
Abstract
Process Analytical Technology (PAT) plays a crucial role in the design of today’s manufacturing lines as continuous manufacturing becomes more important. Until now PAT tools to measure the ribbon solid fraction (SFribbon) in-line are not commonly used in roll compaction. The aim of this…
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Quantifying Crystallinity of Amlodipine Maleate in Amorphous Solid Dispersions Produced by Fluidized…
Abstract
One of the main concerns with formulations containing amorphous solid dispersions (ASDs) is their physical stability. Stability can be compromised if a formulation contains any residual crystallinity of an active pharmaceutical ingredient (API) that could act as seeds for further…
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Patches containing quercetin microcapsules to ameliorate dermal herpes simplex virus injuries in…
Abstract
This study aimed to develop patches containing quercetin-loaded microcapsules and to evaluate their in vitro and in vivo safety and efficacy in preclinical surveys. A set of in vitro experiments evidenced the virucidal activity of quercetin against the HSV-1-KOS (sensitive to acyclovir)…
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Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug
Abstract
Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.
Objectives: The aim of the study was to develop and characterize an optimal ODF…
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