Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
Browsing Category
Pharmaceutical Oils
Optimization of nano-structured lipid carriers for enhanced salbutamol delivery via buccal…
Abstract
Salbutamol sulphate (SS) is a widely prescribed β2 agonist for different respiratory disorders. However, its short plasma half-life and poor oral bioavailability strongly limit its compliance. This study targeted formulating SS in nanostructured lipid carriers (SS-NLCs) embedded in a…
Read More...
Read More...
Development of targeted lipid nanoparticles for the combined therapy of triple negative breast…
Abstract
In the study of triple-negative breast cancer (TNBC) therapeutic approaches, researchers have recently focused on exploiting P-glycoprotein (P-gp) and hypoxia-inducible factor (HIF) inhibitors to enhance the effectiveness of chemotherapeutic agents, which are often limited by poor…
Read More...
Read More...
Systematic Review of Plant-Based Excipients in Topical Drug Delivery
Abstract
This review explores the use of plant-based excipients in topical drug delivery. The review examines the advantages and challenges of using plant-based excipients, as well as case studies that demonstrate their effectiveness in delivering drugs through the skin. The review also discusses…
Read More...
Read More...
Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic…
Abstract
Recent advances in nanotechnology have enabled significant developments in health through innovative drug delivery systems. Nanostructured lipid carriers (NLCs) have emerged as a key technology in this field, offering enhanced drug stability, improved loading capacity, and reduced drug…
Read More...
Read More...
Development and Characterization of Olaparib-Loaded Solid Self-Nanoemulsifying Drug Delivery System…
This study aims to enhance the solubility of Olaparib, classified as biopharmaceutical classification system (BCS) class IV due to its low solubility and bioavailability using a solid self-nanoemulsifying drug delivery system (S-SNEDDS). For this purpose, SNEDDS formulations were created using…
Read More...
Read More...
Solid Self Nano-Emulsifying Drug Delivery System of Dasatinib: Optimization, In-vitro, Ex-vivo and…
Abstract
Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST was formulated.
Methods: I-optimal mixture design was used for optimization of DST-loaded SNEDDS using…
Read More...
Read More...
Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of…
Abstract
Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, in stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® …
Read More...
Read More...
The Ultimate Guide to Soft Gelatin Capsule Manufacturing
Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
Read More...
Read More...
Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with…
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should…
Read More...
Read More...
Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these…
Read More...
Read More...