Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
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Pharmaceutical Oils
A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative…
Abstract
Bigel, formed by high-speed shearing of hydrogel and oleogel, is suited to deliver both lipophilic and hydrophilic active compounds. patchouli oil and paeoniflorin, despite their potential in treating ulcerative colitis, face challenges due to patchouli oil’s poor aqueous solubility and…
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Unlocking the potential of remdesivir: innovative approaches to drug delivery
Abstract
Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as an antiviral agent is critical. While several reviews have explored the efficacy of remdesivir, few have comprehensively addressed its challenges, such as the…
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Design, Characterization, and Evaluation of Solid-Self-Nano-Emulsifying Drug Delivery of Benidipine…
Abstract
The main purpose of this study was to design and develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) for the oral administration of benidipine (BD) and telmisartan (TEL) using the adsorption method with eucalyptus oil, Transcutol P, and Kolliphor EL via the Box–Behnken…
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Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia…
Abstract
Background: Alopecia areata is an autoimmune disorder that causes hair loss in clumps about the size and shape of a quarter. The estimated prevalence of the disorder is approximately 1 in 1000 people, with a lifetime risk of approximately 2 percent. One of the systemic therapies for…
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Investigation of bioavailability and anti-pancreatic cancer efficacy of a self-nanoemulsifying…
Abstract
Aims
A new self-nanoemulsifying drug delivery system (SNEDDS) was developed for erlotinib (Ert) oral delivery.
Highlights
A pseudo-ternary phase diagram for olive oil, Tween 80 and PEG 600 was constructed.
A SNEDDS composed of 10% olive oil, 20% Tween 80 and 70% (V)…
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Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and…
Abstract
This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol using mesoporous silica nanoparticles (MSNs). The liquid self-nanoemulsifying drug delivery system (L-SNEDDS) consisted of carvedilol, Peceol,…
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Design and optimization of bifunctional peptides for controlled core–shell nanocapsule formation
Abstract
Nanocapsules with core–shell structures hold significant potential across diverse applications. Biomimetic templating offers a benign approach for synthesizing inorganic nanostructures using biomolecules, leveraging amino acid sequences from natural sources and combinatorial biology in a…
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Optimization of nano-structured lipid carriers for enhanced salbutamol delivery via buccal…
Abstract
Salbutamol sulphate (SS) is a widely prescribed β2 agonist for different respiratory disorders. However, its short plasma half-life and poor oral bioavailability strongly limit its compliance. This study targeted formulating SS in nanostructured lipid carriers (SS-NLCs) embedded in a…
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Development of targeted lipid nanoparticles for the combined therapy of triple negative breast…
Abstract
In the study of triple-negative breast cancer (TNBC) therapeutic approaches, researchers have recently focused on exploiting P-glycoprotein (P-gp) and hypoxia-inducible factor (HIF) inhibitors to enhance the effectiveness of chemotherapeutic agents, which are often limited by poor…
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Systematic Review of Plant-Based Excipients in Topical Drug Delivery
Abstract
This review explores the use of plant-based excipients in topical drug delivery. The review examines the advantages and challenges of using plant-based excipients, as well as case studies that demonstrate their effectiveness in delivering drugs through the skin. The review also discusses…
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