Pharma Excipients
3D Printing
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery…
Abstract
Microneedle drug delivery has recently emerged as a clinical method, and dissolving microneedles (DMNs) offer exclusive simplicity and efficiency, compared to the other kinds of microneedles. The tips of most currently available DMNs are cone/house-shaped to result in a lower penetration…
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Application of 3D printing technology for the development of dose adjustable geriatric and pediatric…
Abstract
Developing safe and effective formulations for the geriatric and pediatric population is a challenging task due to issues of swallowability and palatability. The lack of standardized procedures for pediatric formulations further complicates the process. Manipulating adult formulations…
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3D-Printed Lipid Mesophases for the Treatment of Chronic Liver Disease
Abstract
Although lipid-based formulations are an attractive approach for enhancing the oral bioavailability of lipophilic drugs, their addition into solid oral dosage forms has been proven challenging due to their high viscosity and heat sensitivity. Therefore, unlike the traditional tableting…
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Open-source extrusion 3D bioprinters: Trends and recommendations
Three-dimensional (3D) extrusion bioprinting, an additive manufacturing process that hybridizes traditional thermoplastic 3D printing technology with the latest developments in tissue engineering, is a promising tool for engineering lab-scale tissues and organs for drug screening, pathological…
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Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D…
Three-dimensional (3D) printing is a potential technique for developing personalized medicines. Among its applications, mold manufacturing in industrial 3D printing stands out, especially for creating complex structures. This capability has been innovatively extended to drug development. Our study…
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Excipients in Pharmaceutical Additive Manufacturing: A Comprehensive Exploration of Polymeric…
Abstract
This review provides a comprehensive overview of additive manufacturing (AM) or 3D-printing (3DP) applications in the pharmaceutical industry, with a particular focus on the critical role of polymer selection. By providing insights into how material properties influence the 3DP process and…
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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We…
Abstract
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful…
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Application of 3D printing in early phase development of pharmaceutical solid dosage forms
Abstract
Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing…
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Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle…
Abstract
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt extrusion (HME), using caffeine as the model compound. Three different ER tablets were developed, which obtained…
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Tailoring drug release in bilayer tablets through droplet deposition modeling and injection molding
Abstract
This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to customizing dense bilayer medicines, our approach uses…
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