Speciality Excipient

Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity. Indeed, it is estimated that only 10–15% of the drug reaches the deep lung while 20% of…
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EMDEX® is a directly compressible, 100% water soluble, and lactose-free tablet binder. It is composed of a unique combination of glucose monohydrate and different polysaccharides derived from starch. When used in direct compression, EMDEX® shows superior flow, compaction, and tablet robustness.…
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In pharmaceutical formulations, polymers are traditionally and commonly used as viscosifier, binder, gelling agent, suspending agent, protective agent, controlled-release medium, adhesive, and packaging material. With the development of the abuse-deterrent formulations in recent years, a new…
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Drug solubility is a persistent challenge in pharmaceutical product development. The objective of this research is to develop a formulation/processing strategy by means of a biodendrimeric solid dispersion (BDSD) platform, for increasing the solubility and dissolution rate of poorly water-soluble…
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A drug-dev.com article by Dr. William Small and Arsalan Khan It wouldn’t come as a surprise to anyone that active pharmaceutical ingredients (APIs) come in a wide variety. Small molecule, large molecule, peptide, monoclonal antibody, innovative, generic; the list goes on. These molecules have the…
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Located right in between Uppsala University, the Swedish Medical Products Agency and Uppsala University Hospital, the company is well positioned to exploit its pioneering discovery of a unique mesoporous magnesium carbonate (MMC) material. Up until breakthrough discovery by the group of professor…
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Achieving drug delivery at the ocular level encounters many challenges and obstacles. In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work…
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Sucrose is a common cyro- and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage. Sucrose based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb) containing products need to be stored refrigerated. The objective…
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Flow aid additives are commonly used in industries to improve the processing of cohesive powders. A wide variety of additives are available: magnesium or calcium stearate, fumed and mesoporous silica, talc, etc. The efficiency of the additive depends on the cohesive forces playing a role in the…
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In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery. Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other areas such as catalysis, purification, and adsorption. The…
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