Calcium Phosphates

Abstract Inorganic hydroxyapatite microcapsules are innovative drug delivery devices tailored for oral drug delivery. They were designed as novel excipients, the so-called template inverted particles (TIP), to assist in preparing the orally disintegrating tablets. This study characterized the drug…
Read More...

Abstract Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving…
Read More...

Abstract Parkinson's disease is a debilitating neurodegenerative disorder that is primarily characterized by dopamine deficiency, which significantly impairs motor function and quality of life. Levodopa remains the gold standard treatment due to its efficacy in replenishing dopamine levels.…
Read More...

Dr. Paul Lohmann proudly presents: Essential Phosphates – Their Role in Medical Treatment Potassium, Sodium, and Calcium Phosphates are vital compounds used in modern medicine to support and stabilize the body’s electrolyte and fluid balance. These essential substances play a…
Read More...

Abstract Tablets are subjected to collisions during processing and handling which can result in defects and even failed batches at commercial scale. This study investigated the influence of composition and tablet shape on the tablet integrity under simulated stressed settings. Tablet formulations…
Read More...

Abstract Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been investigated. The strength of these influences can significantly…
Read More...

Abstract Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level co-occurrence matrix (GLCM) based…
Read More...

Abstract The administration of veterinary medicines via drinking water or feed ingredients is a widely adopted method in intensive livestock and poultry farming due to its convenience and cost-effectiveness. Among these drugs, antimicrobials are extensively used, with over 70% of global…
Read More...

Introduction There are several approaches in order to develop tablet formulations. On the one hand, high functionality excipients that follow the concept “API+1” offer many advantages like easier handling, higher compactability and they combine synergistic effects. In addition, they eliminate the…
Read More...

Abstract It is widely believed that compaction simulators can replicate the uniaxial compression process of a roller compactor. The correction factor (Kp) is a parameter used to adjust a mathematical model for compaction simulation to obtain the same product relative density, therefore accounting…
Read More...