Pharma Excipients
Calcium Phosphates
Fujicalin®: Revolutionizing Axitinib Delivery with Liquisolid Technology
Introduction
Axitinib (AXT), a second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR), is used in the treatment of advanced renal cell carcinoma (RCC). Despite its efficacy, AXT's clinical application is limited by its poor aqueous solubility and bioavailability,…
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Particle-based investigation of excipients stability: the effect of storage conditions on moisture…
Abstract
Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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The impact of glidants on the rheological properties of active pharmaceutical ingredients: A study…
Abstract
Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing…
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Fujicalin®: Your Partner in Mitigating Nitrosamine Impurities in Drug Products
This newsletter by Fuji Chemical Industries highlights how Fujicalin®, a low nitrite content Dicalcium Phosphate Anhydrous (DCPA), can support manufacturers in mitigating these risks effectively.
THE ISSUES
The rise of nitrosamines in pharmaceuticals is a significant concern due to their potential…
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FT-NIR models for predicting film quality parameters in titanium dioxide-free tablet coatings
Abstract
This study leverages Fourier Transform Near-Infrared (FT-NIR) spectroscopy to monitor the coating process of pharmaceutical tablets using PVA-based TiO2-free films, with talc and iron oxides as opacifiers. By employing a combination of multivariate analytical techniques to evaluate the…
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Analysis of Swelling and Dissolution Dynamics of Xanthan Gum-Excipient Blends Using Dissolution…
Abstract
This research investigates how dissolution imaging can elucidate the impact of excipients with various solubility profiles (lactose, microcrystalline cellulose, and dicalcium phosphate) on the swelling and drug release properties of xanthan gum (XG) compacts using a dissolution imaging…
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The effect of filler particle size on API homogeneity of controlled release formulations via…
Abstract
Previous research has shown that controlled release (CR) formulations with hydrox- ypropyl methylcellulose (HPMC) as hydrophilic matrix former produced via twin-screw wet granulation (TSWG) yield granules with an inhomogeneous active pharmaceutical ingredient (API) distribution (Denduyver…
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Achieving tunable and interconnected porosity of biomimetic apatite scaffolds through Pickering…
Abstract
Synthetic apatitic calcium phosphates are widely used to develop biomaterial devices due to their excellent biological properties. The aim of this study was to develop nanocrystalline apatitic calcium phosphates (NCA) bioceramics with tunable porosity (size of pores, total porosity…
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Development and Evaluation of Lactose-Free Single-Unit and Multiple-Unit Preparations of a BCS Class…
Abstract
Background/Objectives: The aim of the present study was to develop lactose-free formulations of rivaroxaban, a novel oral anticoagulant used for the treatment and prevention of blood clotting. As a BCS Class II drug, rivaroxaban is characterized by poor solubility in aqueous media, posing…
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Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on…
Abstract
The viability of probiotic microorganisms is essential for their health-promoting effects and must be preserved in the best possible way during the production of the final dosage form, such as tablets. This applies to both drying and tableting. Saccharomyces cerevisiae is spray-dried…
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