Pharma Excipients
Calcium Phosphates
Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are…
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Exploring Immersion Coating as a Cost-Effective Method for Small-Scale Production of Enteric-Coated…
Abstract
The coating process for solid dosage forms is widely used in the pharmaceutical industry but presents challenges for small-scale production, needed in personalized medicine and clinical or galenic settings. This study aimed to evaluate immersion coating, a cost-effective small-scale…
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Compaction and Structural-Mechanical Properties of Tablets as a Function of Volume Ratios of…
Introduction
Using in tablet formulations microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4 ) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural-mechanical properties of tablets.…
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Tabletability of Roll Compacted Binary Mixtures of Dicalciumphosphate with Silicified and…
JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the second poster:
Introduction
Roll compaction/dry granulation (RCDG) is nowadays not only applied for water or heat sensitive active pharmaceutical ingredients, but has become a standard technique in…
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Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized…
Abstract
Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application of liposomal pMDIs…
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Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature…
Introduction
High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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The Role of BARETab Nutra DS in Direct Tablet Compression Method
BARETab Nutra DS is a novel Co-Processed excipients which is a combination of three Pharmacopeial excipients made by Co-Processing Technology. BARETab Nutra DS contains Dibasic Calcium Phosphate Anhydrous (Filler), Microcrystalline Cellulose (Binder) and Crosscarmellose Sodium (Disintegrant).…
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The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the…
Abstract
Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of…
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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We…
Abstract
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful…
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Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct…
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the…
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