Pharma Excipients
Calcium Phosphates
Advancements in Colon-Targeted Drug Delivery: A Comprehensive Review on Recent Techniques with…
Abstract
This review investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding of the colon's anatomy and physiological environment. Recognizing the distinctive features of the colon is crucial for successfully formulating…
Read More...
Read More...
Data-driven insights into the characteristics of liquisolid systems based on the machine learning…
Abstract
Liquisolid systems (LS) represent a formulation approach where liquid drug or its dispersion is transformed into a powder with good flowability and compactibility, leading to enhanced drug dissolution and bioavailability. Many research groups have focused on the preparation and…
Read More...
Read More...
Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000
This poster was presented at the DDF Summit Conference 2024 by Valentyn MOHYLYUK, Zoltán Márk HORVÁTH, Kirils KUKULS, Liga LAUBERTE, Artūrs PAULAUSKS from Rīga Stradiņš University:
Introduction
Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is…
Read More...
Read More...
Calcium phosphate microcapsules for paediatric drug delivery
This poster was presented by Galvita at EuPFI 2024 in Rotterdam
Introduction
Modern drug delivery needs to use novel multifunctional materials for developing medicinal products and new therapies. Porous particles attract a lot of attention as promising drug delivery systems. Functions of porous…
Read More...
Read More...
Principles, Applications and Limitations of the Liquisolid System of Drug Delivery: A Review
Abstract
The liquisolid system of drug delivery continues to find usefulness as a potent means to circumvent solubility and dissolution challenges commonly encountered during drug formulation and medicine development in the pharmaceutical industry. Originally invented by Spireas, the technique has…
Read More...
Read More...
Towards the prediction of barrel fill level in twin-screw wet granulation
The barrel fill level is defined as the fraction of the free available volume for a given screw configuration that is occupied by the wet material and is an interplay of the material throughput, screw speed, screw setup, barrel length of the twin-screw granulator used and the properties of the…
Read More...
Read More...
Twin-screw melt granulation with PEG 8000: Effect of binder particle size and processing temperature…
Twin-screw melt granulation (TSMG) is one of the promising green technological approaches for the manufacturing of solid dosage forms of pharmaceuticals and nutraceuticals. PEG 8000 is one of the most popular TSMG binders. The effect of different low-melting grades of PEG on the TSMG granules’…
Read More...
Read More...
Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time
Dwell time is an important parameter responsible for the material deformation and the mechanical and biopharmaceutical properties of the tablet. Thus, it is widely used for scale-up purposes. The geometric dwell time (GDT) can be assumed based on the shape of the punch head and the diameter and…
Read More...
Read More...
Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during…
Read More...
Read More...
Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization aid was investigated. Furthermore, the impact of cations on extrusion-spheronization (ES) of CCS was studied and different grades of CCS were tested.…
Read More...
Read More...