Pharma Excipients
Starch
Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update
Abstract
During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery of the various other types of medications. For these to…
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Preparation, Characterization, and Evaluation of a Novel Co-Processed Excipient as a Directly…
Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and characterize pregelatinized starch-polyvinylpyrrolidone (PGS-PVP)…
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Easy Tableting with Natural Disintegrants
Evaluation of a new disintegrant mixture from natural resources
Introduction
Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are…
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Self-microemulsifying drug delivery system as carrier for the oral delivery of glimepiride:…
Abstract
Aim: The research aimed to design the glimepiride self-micro emulsifying drug delivery system (SMEDDS) for increased oral bioavailability in albino mice by assessing hypoglycemic efficacy.
Materials and Methods: The optimized liquid SMEDDS (L-SMEDDS) prepared by emulsification of…
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Medication Lubricants for Oral Delivery of Drugs: Oral Processing Reduces Thickness, Changes…
Abstract
Swallowing oral solid dosage forms is challenging for those who have medication swallowing difficulties, including patients with dysphagia. One option is to mix the drug (whole or crushed) with a thick vehicle (medication lubricant). Previous in vitro studies consistently suggest that…
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Liquisolids: A Modernistic approach in Drug Delivery System
Abstract
Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized…
Abstract
The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data matrix-generator software specifically focused on the healthcare…
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Overcome Challenges of Elastic Deformation with the Right Excipient – Case Study With…
Abstract
Developing a medicine in which the active ingredient has elastic deformation is always challenging, as elastic forces affect the compression capacity of the formulation, resulting in tablets with capping, low tablet breaking force and high friability. Finding an ideal formulation with…
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Influence of Nozzle Geometry and Scale-Up on Oil Droplet Breakup in the Atomization Step during…
Spray drying of oil-in-water emulsions is a widespread encapsulation technique. The oil droplet size (ODS) significantly impacts encapsulation efficiency and other powder properties. The ODS is commonly set to a specific value during homogenization, assuming that it remains unchanged throughout the…
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The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid…
Abstract
Amorphous solid dispersion (ASD) is an effective approach for enhancing the solubility, dissolution, and bioavailability of poorly water-soluble drugs. However, these metastable forms can transform into more thermodynamically stable, less soluble crystalline forms. Despite this…
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