Pharma Excipients
Starch
Advances in Taste-Masking Strategies for Pediatric Brain-Related Disease Treatments: Focus on…
Abstract
Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus
Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related…
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Evaluation of AaltoCell as a filler for tablets compressed from high-shear wet granulated…
Abstract
Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose, which is obtained by treating αcellulose with mineral acids. Ever since the first microcrystalline cellulose was commercialized, different grades of microcrystalline cellulose have widely been used in the…
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The dissolution and bioavailability of curcumin reinforced by loading into porous starch under…
Abstract
Curcumin is a polyphenol with anti-inflammatory and antitumorigenic properties. However, its low water solubility and bioavailability limit its use. In this study, porous starch supplemented with a solvent evaporation process was demonstrated as a highly loaded vehicle for curcumin…
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Advances in Co-Processed Excipients: Multifunctional Platforms for Diverse Pharmaceutical…
Abstract
As it adds so many advantages to the finished formulations, excipient utilised in pharmaceutical dosage forms is a special and important ingredient that is just as important as the API. Improving API absorption and bioavailability, boosting organoleptic characteristics and filling the…
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3D Printed pH-responsive Colonic Capsules for the Delivery of Live Aqueous Bacterial Suspensions
Abstract
Delivering live bacterial therapeutics to the colon orally is challenging due to the harsh gastrointestinal (GI) conditions and/or the manufacturing processes involved in the production of dry formulations, which can drastically decrease cell viability. In previous work, we evaluated the…
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Pediatric-friendly suspension for oral administration of pyrimethamine in congenital toxoplasmosis:…
Abstract
This study focused on developing and assessing the stability of pyrimethamine (PYM) sugar-free oral suspensions for treating congenital toxoplasmosis in the pediatric population, including neonates. Extemporaneous suspensions (2 mg/mL) were prepared using carboxymethylcellulose (CMC) or…
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Systematic Review of Plant-Based Excipients in Topical Drug Delivery
Abstract
This review explores the use of plant-based excipients in topical drug delivery. The review examines the advantages and challenges of using plant-based excipients, as well as case studies that demonstrate their effectiveness in delivering drugs through the skin. The review also discusses…
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Mucoadhesion across scales: Towards the design of protein-based adhesives
Abstract
Mucoadhesion is a special case of bioadhesion in which a material adheres to soft mucosal tissues. This review elucidates our current understanding of mucoadhesion across length, time, and energy scales by focusing on relevant structural features of mucus. We highlight the importance of…
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Advancements in Colon-Targeted Drug Delivery: A Comprehensive Review on Recent Techniques with…
Abstract
This review investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding of the colon's anatomy and physiological environment. Recognizing the distinctive features of the colon is crucial for successfully formulating…
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