Starch

Abstract A novel polymer synthesized by grafting three cyclodextrins onto chitosan was characterized and evaluated for its potential to adsorb two pharmaceutical residues: ibuprofen and progesterone. The influence of various operational parameters, including contact time, initial molecule…
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Abstract Background: Due to its simplicity and cost-effectiveness, direct compression has become the approach most frequently used to create tablet. Nonetheless, the active pharmaceutical ingredient should have acceptable flow and good compaction qualities in order to use direct compression in…
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Abstract Nanocrystals derived from organic particles, such as starch, can be produced through acid or enzymatic hydrolysis reactions to serve as stabilizers in Pickering emulsions. Starch nanocrystals (SNCs) offer the advantage of providing enhanced storage stability and controlled in vitro and …
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Abstract Stability studies are essential for assessing the quality, safety, and efficacy of pharmaceutical products, ensuring they maintain their properties over time. This study aimed to assess the stability of metronidazole tablets stored in a desiccator with charged silica gel following the…
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Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides are degraded by colonic enzymes (secreted by bacteria), triggering the…
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Soft Gelatin Capsules (SGCs), commonly known as softgels, have transformed drug delivery since their invention. Despite their 19th-century origins, their widespread adoption only began in the 20th century, thanks to technological advancements by Robert Pauli Scherer. This innovation revolutionized…
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The magnitude of the frictional forces during the ejection of porous pharmaceutical tablets plays an important role in determining the occurrence of tabletting defects. Here, we perform a systematic comparison between the maximum ejection force, static friction coefficient, and kinetic friction…
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Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with…
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A set of numerical methods is described that allows predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across the entire range of compositions. An automated parametrisation procedure was used to extract density-dependent…
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ABSTRACT Background Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention. Aim This study aimed to develop…
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