Pharma Excipients
Polyethylene Glycol
Study of PEG-b-PLA/Eudragit S100 Blends on the Nanoencapsulation of Indigo Carmine Dye and…
A nanocapsule shell of poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) mixed with anionic Eudragit S100 (90/10% w/w) was previously used to entrap and define the self-assembly of indigo carmine (IC) within the hydrophilic cavity core. In the present work, binary blends were prepared by…
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Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood…
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral formulations. Therefore, it is necessary to understand the effects of excipients on the behavior of SEDDS formulations upon parenteral administration, particularly…
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Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA…
Abstract
EMA and FDA are upgrading guidelines on assessing the quality and the equivalence of topically applied drug products for developing copies of originator products and supporting post-marketing variations. For topical products having remarkably similar composition, both EMA and FDA accept…
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Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a…
As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that usually consist of a combination of liquid lipids, cosolvents,…
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Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming…
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Development of a New Bioequivalent Omeprazole Product
Abstract
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that its population has access to affordable…
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Self-microemulsifying system of an ethanolic extract of Heliopsis longipes root for enhanced…
Abstract
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component,…
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Fabrication of suppository shells via hot-melt extrusion paired with fused deposition modeling 3D…
Three-dimensional (3D) printing is a potential technique for developing personalized medicines. Among its applications, mold manufacturing in industrial 3D printing stands out, especially for creating complex structures. This capability has been innovatively extended to drug development. Our study…
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Solid dispersions of bedaquiline fumarate to improve its pharmaceutical attributes: A comparative…
Abstract
Objectives
The therapeutic delivery of hydrophobic drugs via solid dispersion is an appealing methodology to enhance the dissolution rate and ultimately the in vivo bioavailability. The objective of current investigation was to enhance the solubility of anti-tubercular drug bedaquiline…
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Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle…
Abstract
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt extrusion (HME), using caffeine as the model compound. Three different ER tablets were developed, which obtained…
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