Pharma Excipients
Polyethylene Glycol
Pickering emulsion gels stabilized by protein and polysaccharide-based particles: A review of…
Abstract
With a far longer stability than traditional emulsions, Pickering emulsion gels (PKEGs)—stabilized by solid particles—have proven highly efficient in a range of applications during recent years. Particles based on proteins or polysaccharides with distinctive amphiphilic structure are…
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From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance
Abstract
Lipid nanoparticles (LNPs) are widely employed for delivering nucleic acids, such as mRNA, in both vaccines and therapeutic applications. These LNPs generally include an ionisable lipid (typically ∼ 50 %) to facilitate nucleic acid encapsulation and a PEG-lipid (typically ∼ 1.5 %) to…
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Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality…
Abstract
Aim
The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD.
Materials and Methods
The solvent casting method was used to formulate fast dissolving thin strips. The drug (Desvenlafaxine HCl), polymer
(pullulan), super…
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Thermostabilization of a model viral-vectored oral thin film vaccine
Abstract
Vaccines rely on a global cold chain to maintain vaccine potency throughout the product life cycle. Existing vaccine thermostabilization methods like lyophilization and spray-drying impart significant stress on the vaccine, reducing its potency. Therefore, dissolvable oral thin films…
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Unlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid…
Abstract
Exenatide, a first-in-class GLP-1 receptor agonist, is used to control glycaemic levels in type 2 diabetes. There are two approved injectable formulations: one solution for immediate action and one dispersion for prolonged action. Oral exenatide has low bioavailability due to poor…
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Advances in the Oral Delivery of Protein and Peptide Drugs
Abstract
Protein and peptide drugs (PPDs) are highly effective therapies for a wide range of diseases, including cancer, diabetes, and autoimmune disorders . However, delivering these drugs orally presents significant challenges. PPDs face substantial barriers to attaining oral bioavailability,…
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Preparation of self-dispersible eutectic mixtures for poorly soluble drugs: Hot-melt extrusion vs.…
Abstract
Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in terms of processability and dissolution rate at, below, and above the eutectic concentration. Furthermore, the effects…
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PLGA Implants for Controlled Drug Delivery and Regenerative Medicine: Advances, Challenges, and…
Abstract
Poly(lactide-co-glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and…
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and…
Abstract
Aim
Proteolysis targeting chimeras (PROTACs) exhibit a unique and promising pharmacology. However, this comes with molecular properties exceeding the ‘drug-like’ rule of five chemical space, which often limits gastrointestinal absorption. This in vivo study aimed to investigate the…
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Biological applications on a novel composite hydrogel containing mesoporous silica nanoparticles…
Abstract
Polymer nanocomposites have prolific applications in the environmental and health domain. Healthcare workers have constantly faced a challenge in constructing an effective sustained-release system for drugs, especially in areas where it is difficult to follow traditional treatment…
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