PVP-Iodine

Skin and mucous membrane antisepsis as well as

surgical and hand disinfection

 

PVP-Iodine is an antiseptic that offers a broad spectrum of coverage, demonstrating antiviral, antibacterial, and antifungal activity. Found on the World Health Organization’s Model List of Essential Medicines, PVP-Iodine’s potent efficacy is balanced with its established safety profile in a wide range of ages spanning from pediatric to geriatric patients.In-vitro studies of PVP-Iodine-based topical formulations including skin cleansers, topical scrubs, and gargle/mouthwashes have indicated that PVP-Iodine products reduce viral load of certain coronaviruses such as MERS-CoV, SARS-CoV-1, and SARS-CoV-2.

PVP-Iodine is known for its wide range of uses:

• Skin and mucous membrace antisepsis
• Surgical and hygienic hand disinfection
• Treatment of burns, decubitus, varicose ulcers, dermatomycosis, pyoderma, acne and vaginitis
• PVP-Iodine is used in topical formulations such as solutions, gels, creams, ovulas and others

 

SAMPLE REQUEST

---

PVP-Iodine has been investigated for virucidal activity

• PVP-I activity specifically against strains of Coronavirus (MERS, SARS and SARS-CoV-2) has been tested in vitro in recent studies
• PVP-I based 7% gargle mouth wash formula showed in vitro rapid inactivation2 of MERS CoV and SARS CoV in 15s exposure
• PVP-I based 4% skin cleanser formula showed >99.99% inactivation of MERS CoV in 15s exposure
• The mode of action is related to the active I form, e.g. oxidizing vital pathogen structures and disrupting cellular membranes
• Several commercial PVP-I-based products were tested under European guidelines5 (EN 14476, EN 1499) with proven virucidal efficacy
• Certain publications consider that the use of MVA and MVN test models provide data that can be used for decision-making during public health crisis

PVP-I-based skin cleanser and mouth wash products may provide viral decontamination on skin and oral cavity, potentially limiting transmission of coronavirus infection, such as MERS, SARS and SARS-CoV-2 during outbreaks

---

Infographic PVP-iodine

---

Antimicrobial Efficacy of PVP-Iodine

 

The antimicrobial efficacy of PVP-Iodine is dependent on two major factors:

• Available iodine = iodine that can be titrated with sodium thiosulphate
• Free iodine = non-complexed, free iodine that can be determined in a dialysis test or an electrochemical model

 

Free iodine content is inversely proportional to the concentration of PVP-Iodine or available iodine. Tests on micro-organisms have shown that the rate of microbicidal action is proportional to the free iodine content.

---

Foam:

• Suitable for large surface applications
• Easy to apply
• Fast spreading
• Non-leaking
• Clean application – prevents body, cloths and furniture from contamination

 

---

Cream:

• Improved sensory feeling compared to PVP-iodine ointments
• Better spreading compared to PVP-iodine ointments

 

 

---

Ointments:

• Hydrophilic and free of mineral oil
• Higher viscosity for improved richness and care feeling

 

 

 

---

Stick:

• Provides occlusive barrier
• Simple, water-free formulation
• Suitable mainly for small skin surface areas
• Very precise and local application (“spot on”)
• Dry and clean application

---

Sprayable thermo-reversible poloxamer gels:

• Sprayable gel using thermo-reversible gellification upon contact with skin
• Local and precise application
• No leaking or easy wash-off

 

 

 

---

Hydrophilic poloxamer gels:

• Thermo-reversible gelling agent builds viscosity upon contact with skin
• Cool, refreshing feeling
• Easily spread
• Targeted application to small or large surface areas

 

 

---

Brochures and Information:

• PVP-Iodine and COVID-19
• Differentiating PVP-Iodine formulations
• One-Pager PVP-Iodine
• Booklet PVP-Iodine Application Guide 2020

SAMPLE REQUEST

CONTACT BASF DIRECTLY HERE