Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Spray Dried Lubricants Offering Enhanced Flowability
Introduction
There are several approaches in order to develop tablet formulations. On the one hand, high functionality excipients that follow the concept “API+1” offer many advantages like easier handling, higher compactability and they combine synergistic effects. In addition, they eliminate the…
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Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms…
Abstract
The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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A powerful carrier adapted for HME process to formulate stable ASD’s while avoiding downstream…
This poster was presented at the ECP 2025 in Porto
Introduction
Hot melt extrusion (HME) is generally applied for the formulation of amorphous solid dispersions (ASD) aiming to enhance the solubility of poorly water-soluble drugs . The aim of this work was to evaluate the use of an innovative dry…
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Effect of Magnesium Stearate Lubrication on the Tableting of Spray-dried Grades of Mannitol and…
This poster was presented at the ECP 2025 in Porto
Introduction
Polyols, such as mannitol, sorbitol, and isomalt, are widely used as excipients for tablet direct compression formulations because of their excellent compaction properties, flowability, as well as high and pH independent…
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Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression
Abstract
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
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Design of Experiments (DOE) – An essential tool to better understand tablet formulations
This paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets and gives an example of how to design piroxicam amorphous solid dispersions (ASD) tablets using…
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Accelerated Medicines Development using a Digital Formulator and a Self-Driving Tableting…
Abstract
Pharmaceutical tablet formulation and process development, traditionally a complex and multi-dimensional decision-making process, necessitates extensive experimentation and resources, often resulting in suboptimal solutions. This study presents an integrated platform for tablet formulation…
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Engineering pH-Dependent Orally Disintegrating Tablets for Modified Indomethacin Release: A…
Abstract
The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
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Compaction Characterisation of Piroxicam Amorphous Solid Dispersions Formulations
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Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs . They are comprised of high molar mass polymer carriers that stabilise the active pharmaceutical ingredients (APIs) in their amorphous state.…
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Mixing efficiency of pharmaceutical powders in an intensive mixer with rotating mixing vessel
The mixing of ductile lubricant particles is known to have several negative effects on tablet properties, such as decreased hardness and delayed disintegration. This study investigated the usefulness of a mixing system using an intensive mixer with a rotating mixing vessel (EIRICH Intensive Mixer)…
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