Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Engineering pH-Dependent Orally Disintegrating Tablets for Modified Indomethacin Release: A…
Abstract
The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
Read More...
Read More...
Compaction Characterisation of Piroxicam Amorphous Solid Dispersions Formulations
See another MEDELPHARM bulletin:
Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs . They are comprised of high molar mass polymer carriers that stabilise the active pharmaceutical ingredients (APIs) in their amorphous state.…
Read More...
Read More...
Mixing efficiency of pharmaceutical powders in an intensive mixer with rotating mixing vessel
The mixing of ductile lubricant particles is known to have several negative effects on tablet properties, such as decreased hardness and delayed disintegration. This study investigated the usefulness of a mixing system using an intensive mixer with a rotating mixing vessel (EIRICH Intensive Mixer)…
Read More...
Read More...
The Feasibility of the Repeated Administration of Acetylsalicylic Acid Mini-Tablets to Children with…
Background/Objectives: Mini-tablets are a novel pediatric dosage form designed to mask drug taste and facilitate easier administration. This study aimed to assess the feasibility and acceptability of uncoated acetylsalicylic acid (ASA) mini-tablets in Japanese children with Kawasaki disease (KD)…
Read More...
Read More...
Evaluating the flow-enhancing and antistatic properties of excipients in free and salt forms: A case…
Abstract
Powder flow characteristics are crucial for efficient processing and manufacturing in the pharmaceutical industry. The occurrence of tribo-charging, a surface phenomenon where particles acquire an electrical charge due to frictional contacts with other particles or surfaces, poses risks…
Read More...
Read More...
Influence of formulation and punch properties on sticking in the tableting process
Introduction:
Punch sticking is a common phenomenon in tablet manufacturing, often leading to tablet defects and compromise product quality. A thorough understanding of the sticking mechanism is essential to optimize the tablet production process. The aim of this study was to investigate the…
Read More...
Read More...
Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial…
Abstract
Oral drug administration is the preferred route for pharmaceuticals, accounting for ~90% of the global pharmaceutical market due to its convenience and cost-effectiveness. This study provides a comprehensive scientific and technological analysis of the latest advances in oral dosage forms…
Read More...
Read More...
Modulating hygroscopicity and compression performance in chewable mannitol-xylitol tablets: Effects…
Abstract
This study aims to investigate the effects of the relative humidity and formulation ratio on the hygroscopicity, tableting performance, and physical stability of polyols (mannitol and xylitol) as fillers in chewable tablets. To address the issues of hygroscopicity and sticking during…
Read More...
Read More...
Using density changes to monitor blending with magnesium stearate by terahertz time-domain…
Abstract
Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low concentrations, the addition of MgSt substantially…
Read More...
Read More...
Applications of Macrogol Lauryl Ether (Polidocanol) – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
Read More...
Read More...