Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
PROSOLV® RX 90 – Ready-to-Use, High Functionality Excipient Composite for Direct Compression…
Streamline Your R&D and Production
Introduction
The health science industry faces a wide variety of challenges including increased pressure to:
Reduce costs
Accelerate time to market
Improve product performance
Cope with high demands and tight capacities
Utilize modern…
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Twenty grams in two weeks: Material sparing tablet development of direct compression formulations…
Abstract
Material-sparing tablet development (MSTD) describes an approach to tablet formulation development that uses the active pharmaceutical ingredient's (API) material properties to guide formulation design. The work presented here expands on this methodology and demonstrates its application…
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Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder
Abstract
Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Results: Processing parameters, specifically granulation temperature and screw speed, were systematically…
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Influences of variations of the amount of compressed material on compressibility, tabletability and…
Abstract
Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been investigated. The strength of these influences can significantly…
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Spray Dried Lubricants Offering Enhanced Flowability
Introduction
There are several approaches in order to develop tablet formulations. On the one hand, high functionality excipients that follow the concept “API+1” offer many advantages like easier handling, higher compactability and they combine synergistic effects. In addition, they eliminate the…
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Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms…
Abstract
The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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A powerful carrier adapted for HME process to formulate stable ASD’s while avoiding downstream…
This poster was presented at the ECP 2025 in Porto
Introduction
Hot melt extrusion (HME) is generally applied for the formulation of amorphous solid dispersions (ASD) aiming to enhance the solubility of poorly water-soluble drugs . The aim of this work was to evaluate the use of an innovative dry…
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Effect of Magnesium Stearate Lubrication on the Tableting of Spray-dried Grades of Mannitol and…
This poster was presented at the ECP 2025 in Porto
Introduction
Polyols, such as mannitol, sorbitol, and isomalt, are widely used as excipients for tablet direct compression formulations because of their excellent compaction properties, flowability, as well as high and pH independent…
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Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression
Abstract
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
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Design of Experiments (DOE) – An essential tool to better understand tablet formulations
This paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets and gives an example of how to design piroxicam amorphous solid dispersions (ASD) tablets using…
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