Lubricant

The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical properties and near-infrared (NIR) and Raman spectroscopic…
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Magnesium silicate (MgSiO3) when hydrated is most commonly known as “Talc”. In the pharmaceutical industry, talc is used primarily as a glidant to improve powder flow in tablet compression. Of course, talc is also used by the personal care industry in talcum powder as an adsorbent and by the…
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Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need to better understand and share the typical flow properties…
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Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, since it only involves blending and compression. However, active pharmaceutical ingredients (API) generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of…
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The causes of atypical nitrogen adsorption isotherm features of commercial magnesium stearate grades have been investigated through a combination of alternative adsorbates and variation of analytical conditions. Atypical features have previously been identified as having poor linearity of adsorption…
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In this video Chris Moreton gives an interesting insight on pharmaceutical excipients. 
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A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The porosity distribution resulting from the applied stress, was…
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What is an orally disintegrating dosage form? An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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Appropriate lubrication is important in tablet manufacturing as it lowers punch sticking propensity and protects tooling by reducing friction between die wall and tablet during tablet manufacturing. Most commercial lubricants negatively impact tabletability and dissolution. A delicate balance is…
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17. July 2018 By the advent of continuous pharmaceutical manufacturing, fast and accurate characterization of product quality has become of a major interest. Although it also promotes the real-time release testing approach, so far mainly content uniformity studies were…
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