Lubricant

A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The porosity distribution resulting from the applied stress, was…
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What is an orally disintegrating dosage form? An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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Appropriate lubrication is important in tablet manufacturing as it lowers punch sticking propensity and protects tooling by reducing friction between die wall and tablet during tablet manufacturing. Most commercial lubricants negatively impact tabletability and dissolution. A delicate balance is…
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17. July 2018 By the advent of continuous pharmaceutical manufacturing, fast and accurate characterization of product quality has become of a major interest. Although it also promotes the real-time release testing approach, so far mainly content uniformity studies were…
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04. June 2018 The selection of the excipient(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be Dose Particle Size Flow Properties…
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09. May 2018 The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties. The study consisted of preparingglyceryl behenate SLN…
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09. April 2018 Pharmaceutical powders can exhibit markedly different tablet ejection forces. The purpose of this study is to understand the factors leading to the variability of the tablet ejection force and its sensitivity to…
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13. February 2018 Abstract As an essential formulation component for large-scale tablet manufacturing, the lubricant preserves tooling by reducing die-wall friction. Unfortunately, lubrication also often results in adverse…
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