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Sigachi Group

Sigachi

 

1) COMPANY

Since its inception in 1989, Sigachi Group has become a leading global manufacturer of microcrystalline cellulose and a key player in Excipients and Active Pharmaceutical Ingredients (APIs), exporting 70% of its production to over 65+ countries. With subsidiaries in the U.S. and the MEA region, our state-of-the- art facilities in India, located at Dahej, Jhagadia, Sultanpur and Raichur are certified under EXCiPACT GMP, SGMP, HACCP, EDQM CEP, FSSAI, USFDA, and ISO 9001:2015 standards.

Sigachi R&D Team

Continuous innovation is the cornerstone of Sigachi’s success, driven by our robust Research & Development capabilities. With three advanced R&D centers, including one accredited by the DSIR, we are well-equipped to develop new and improved products while optimizing our manufacturing processes.

The culmination of the above factors makes us a favored and trusted supplier in the field of Pharma Excipients, Nutraceuticals and food ingredients.

2) MARKETS & RESEARCH

Sigachi Global Presence MapSigachi, founded in Hyderabad in 1989, has grown into a global organization with a presence in 65+ countries and a strong base of 550+ customers. Our international footprint is strengthened through dedicated subsidiaries in the US and MEA regions, along with strategic joint ventures that support our global growth. Sigachi’s core strength lies in its leadership in cellulose-based excipients, trusted worldwide for their quality, performance, and consistency.

Our portfolio now also includes specialized excipients and coating systems that enhance the stability, texture, and delivery of Pharmaceutical and nutraceutical products. Building on this foundation, we have expanded into the Food & Nutrition sector, offering solutions that support the fortification of dairy, confectionery, beverages, and functional foods.

3) SIGACHI PRODUCT RANGE

Sigachi High Performance Excipients

Wide range of High-Performance Excipients:

We’re one of the world’s largest manufacturers of cellulose-based excipients, playing a critical role in delivering effective and stable pharmaceuticals and nutraceuticals formulations.

Sigachi Coating Premix

Ready-To-Use Coating Premix:

We offer a portfolio of ready-to-use coating premixes for pharmaceutical and nutraceutical tablet formulations.

Sigachi High Performance Excipients

API & Intermediates:

Our diversified portfolio includes active pharmaceutical ingredients (APIs) and their intermediates, supporting the development of lifesaving medications.

4) COATINGS

Our coating offering PureCoat®, a fully formulated ready-mix Film Coating system, adding valuable quality to our portfolio of quality products. PureCoat® comprises meticulously balanced concentrations of polymer, plasticizer,pigments, and opacifiers, ensuring robust and reproducible film coating solutions.

  • Film Coatings

  • Seal Coatings
  • Moisture Protection Coatings
  • Nutraceutical Coating
  • Delayed Release Coatings
ProductPolymersReconstitution
PureCoat™ FCA-HHPMCAqueous and Hydro-Alcoholic systems
PureCoat™ FCS-HHPMCNon-Aqueous system
PureCoat™ FCA-PPVAAqueous system
PureCoat™ Seal-HHPMCNon-Aqueous system
PureCoat™ Seal-PPVAAqueous system
PureCoat™ MPAPVAAqueous system
PureCoat™ MPA-XPVA-Xanthan GumAqueous system
PureCoat™ MPS-PHPMC-PEGNon-Aqueous and Hydro-Alcoholic systems
PureCoat™ MPS-DHPMC-Diethyl PhthalateNon-Aqueous and Hydro-Alcoholic systems
PureCoat™ NutraHPMCAqueous, HydroAlcoholic and Non-Aqueous systems
PureCoat™ Nutra TFHPMCAqueous system
PureCoat™ Nutra T2FHPMCAqueous system
PureCoat™ ESA-AMAC (Type A)Non-Aqueous system
PureCoat™ ESB-BMAC (Type B)Non-Aqueous system
PureCoat™ ECAMAC (Type C)Aqueous system

5) POLYMER BLENDSSigachi ULTRAMOD Optimized Polymer Blend

Optimized Polymer blend for hydrophilic matrices including Hydroxypropyl methylcellulose, Carboxymethyl cellulose sodium, Carbomer. Offering customized solutions specific to the Formulation and target drug release profile and dosage form.

Name of GradeApplication
UltraMod™ SR L• Polymer blend for direct compressible tablet formulation and suitable for Low solubility
category of APIs.
UltraMod™ SR M• Polymer blend that can be used for direct compressible table formulation and suitable for
Medium solubility category of APIs.
UltraMod™ SR H• Polymer blend that can be used for direct compressible table formulation and suitable for
High solubility category of APIs
UltraMod™ SR LW• Polymer blend that can be used in wet granulation process and is suitable for low-solubility
category of APIs.
UltraMod™ SR MG• An optimised and ready to use polymer matrix granules to which, choice of APIs, lubricant
and Silicon dioxide can be added as per the formula composition followed by compress into
tablets. It is suitable for medium solubility category of APIs, especially Diclofenac Sodium.
UltraMod™ SR HW• Polymer blend that can be used in wet granulation process and is suitable for high-solubility
category of APIs.

6) HIGH FUNCTIONALITY EXCIPIENTS

Sigachi High Functionality Excipients

Use HFE’s in your formulation to reduce particle segregation and obtain excellent flowability with good compatibility.

 

GradesDescriptionApplication
HiCel™ SMCCHiCel™SMCC 50MMCC + SiO2• Suitable for optimal compaction with decent flow
• Superior mechanical properties (advantageous for hard gelatin capsules)
HiCel™ SMCC 90M• Median particle sized MCC for optimal compaction with decent flow
• Superior mechanical properties (advantageous for hard gelatin capsules)
HiCel™ SMCC LM90• Low-moisture content (3%) grade
• Recommended for extremely moisture sensitive APIs
HiCel™ SMCC HD
90M
• High BD grade of SMCC, this grade facilitates thinner tablets and provide
best disintegration time.
• Excellent flowability, Superior physico-mechanical properties, i.e., may be
an advantage in hard gelatin capsules

HiCel™SMCC SCG
90M
• Coarser grade SMCC, median particle sized
• Improves compressibility and flowability of the poorly flowable of APIs
Sigachi Excipients
GradesDescriptionApplications
HiCel™CEHiCel™ Ce 15MCC + Guargum• Provides a superior creamier mouth feel
and reduces friability
HiCel™ HFSHiCel™ HFS 90MMCC+Manitol+SiO2• The combination of MCC , Manitol and SiO2,Increases the
flowability and compatibility of the powder.
HiCel™ HFS 50M• Fine grade, combination of MCC, Mannitol & SiO2,
increases the flowability and compatibility of the powder
BARETab® LUBBARETab® LUB 90MBinder + Lubricant• Good compatibility, flowability
• No need of additional lubricant
BARETab® LUB 50M• Fine grade combination, provides good compatibility and
flowability
• No need of additional lubricant
BARETab® LUB LM90• Lower-moisture content (,3.0%) BARETab® grade
• Median particle size
BARETab® FlashBARETab® Flash CS 90MBinder +
Superdisintegrant
• It has superior flowability and compressibility
• Results in shorter disintegration time
BARETab® Flash CS 50M• Fine grade, suitable for coarser API
• Superior flowability and compressibility with shorter
disintegration time
BARETab® Flash CSLM90• Low- moisture grade, suitable for water sensitive APIs
• Superior flowability and compressibility with shorter
disintegration time
BARETab® Flash SG 90MBinder + Disintegrant• Gives superior flowability and compressibility
• Results in shorter disintegration time
BARETab® Flash SG 50M• Fine grade, suitable for coarser API
• Shows superior flowability, compressibility & shorter
disintegration time
BARETab® Flash SG LM90• Low-moisture grade, suitable for water sensitive APIs
• Superior flowability and compressibility with shorter
disintegration time

7 ) PRE-FORMULATED EXCIPIENTSSigachi Pre-Formulated Excipients

Use PFEs in your formulation to enhance the inherent functional performance of the constituents, hence achieving high drug loading of APIs. Decrease batch variability with our PFEs in your formulation for a guaranteed increased batch size and productivity.

GradesDescriptionApplications
BARETab® PHBARETab® PHBinder + Glidant
+ Disintegrant +
Lubricant
• Ready mix for DC tablet formulation
• Provides outstanding flow, compressibility and maintains drug
uniformity throughout the formulation
BARETab® LMPH• Low-moisture content (<3.0%)
• Recommended for extremely moisture sensitive APIs
BARETab® ODTsBARETab® ODT 90MBinder +
Disintegrant +
Sweetener
• Helps in quick dissolving of tablet matrix, superior flow +
compressibility
• Combination of flow and compaction.
BARETab® ODT 50M• Fine sized BARETab ODT, which promotes fast dissociation, flow
and compressibility
• Combination of flow and compaction.
BARETab® NutraBARETab® NUTRA 90MBinder + Glidant +
Disintegrant +
Lubricant
• Mix for DC tablet formulations
• Outstanding flow, good compressibility (Nutra + Food + Pharma)
BARETab® NUTRA LM 90• Low-moisture content (<3.0%) and recommended for extremely
moisture sensitive actives
• Good flow and compressibility
BARETab® NUTRA 50M• Fine grade
• Higher compressibility and suitable for granular APIs.
BARETab® NUTRA DS90MMCC + DCP
Anhydrous +
CCS
• Superior flowability and compressibility for water sensitive API
• Shows good compressibility for tablets
BARETab® NUTRA DS50M• Fine grade
• Superior flow & compressibility for tablets with coarser API.
BARETab® NUTRA DSLM90MCC + DCP
Anhydrou
• Low-moisture grade

8) DISINTEGRANTSSigachi Disintegrants

Disintegrants incorporated into the formulation of tablets or capsules, when contact with water promote rapid disintegration to primary particles and facilitating dissolution.

Brand NameExcipientApplications
StargelSodium Starch Glycolate PotatoDisintegrating Agent
StargelSodium Starch Glycolate MaizeDisintegrating Agent
HiLose ™Croscarmellose SodiumDisintegrating Agent

9) DILUENTS/BINDERSSigachi Diluents_Binders

Binders hold together the ingredients of any solid oral dosage form prepared using different manufacturing procedures as wet granulation or dry granulation, roll compaction or even direct compression.

HiCel ™(Spray
dried)
AceCel
(Bulk
dried)
PSD (μm)LOD (%)
Bulk density
(g/cc)
Applications
25M10514-20NMT 3-50.30-0.25• Very fine grade of MCC
• Provides a pleasant mouth feel
• Masks the bitter taste and supports flavors and used
for tablet coating
50M10140-75NMT 3-50.28-0.34• Fine standard grade of MCC, provides very high
compatibility
• Especially suitable for wet granulation
• Suitable for roller compactor & spheronisation
HD 50M30140-75NMT 3-50.35-0.46• Higher BD grade of MCC
• Fine-particle-sized MCC
• Improved flow properties and higher compressibility
90M10280-140NMT 3-50.28-0.34• Medium sized standard MCC grades
• Suitable for major DC APIs
• Gives good flow & high compatibility at the same time
HD 90M30280-140NMT 3-50.35-0.46• Higher BD MCC grades help in flow improvement
• Especially suitable for high-speed tableting
• Processing high-density APIs
LP 20020080-280NMT 3-50.30-0.36• Coarse grade MCC
• Provides good compatibility, high binding capacity &
outstanding flow.
• Even with low concentration of fine actives
1212120-230 NMT 3-50.30-0.36• Coarse grade of MCC
• Provides good compatibility, high binding capacity and
outstanding flow.
• Provides good CU at low weight variation, even with
low concentration of fine actives
LM 50-40-75NMT 3%0.28-0.34• Low moisture grade MCC for water sensitive API
• Median particle size: 50μm
• Higher compressibility & flowability
XLM 5011340-75NMT 1.5%0.28-0.34• Extra-low moisture content, water sensitive API
• Median Particle size 50μm
• Higher flowability
XLM 9011280-140 NMT 1.5%0.28-0.34• Median particle size• Standard MCC with extra - low
moisture content, suitable for water sensitive APIs
• Suitable for DC formulations
XLM 200-180-280NMT 1.5%0.30-0.36• Extra low- moisture content for water sensitive APIs,
and Coarse grade MCC
• Provides good compatibility, binding capacity with
outstanding flow
• Provides good CU at low weight variation even when
used with low concentration of fine actives
14-120-230vNMT 1.5%0.30-0.36• Extra low moisture grade MCC with coarser particles
• Gives good compatibility, binding capacity with
outstanding flow
• Provide good CU at low weight variation even when
used with low concentration of fine actives

10) GLIDANTSigachi Coating Premix

Talc is used primarily as a glidant and also as a
lubricant. Talc helps to improve powder flow in
tablet compression and helps to reduce die-fraction during tableting. It improves tablet surface and helps to eliminate tablet defects. Talc is also used bythe personal care industry in talcum powder as an adsorbent.

11) THICKENERS / STABILIZERSSigachi Thickeners_Stabilizers

Use thickeners and stabilizers in oral, parenteral or topical pharmaceutical formulations, to obtain optimum viscosity and stability.

GradeDescriptionApplications
HiCel™ MCGHiCel™ MCG 581MCC + CMC• High functional gelling agent in suspensions & emulsions
• Accelerates disintegration and dispersion
HiCel™ MCG 591• Used as stabilizer & thickener in all type of suspensions & emulsions,
also used in sprays
• It binds ingredients together and increases the mechanical strength
of the tablet
HiCel™ MCG 611• Ready-to-use or reconstituable in dry suspension, required low shear
force
• Excellent water uptake capacity, very good stabilizer and thickener
EcoCel®EcoCel® C-1%Calcium Carboxymethyl
Cellulose
Thickener & Stabilizer
EcoCel® N -2%Sodium Carboxymethyl
Cellulose
Thickener & Stabilizer
EcoCel® N -1%Sodium Carboxymethyl
Cellulose
Thickener & Stabilizer

12 ) FUNCTIONAL

Acefibre®( Cellulose Fibre for food)
CoatCel (For Filteration)

13) LUBRICANTSSigachi Lubricants

With lubricants in your formulation ensure continuous operation be it blending, roller compaction, tablet manufacturing, or capsule-filling. These products reduce the friction between the surfaces of manufacturing equipment and that of organic solids.

Brand NameExcipientsApplications
MagLub ®Magnesium StearateLubricating Agent
FloLubTMSodium Stearly FumurateLubricating Agent

14) PELLETSSigachi Pellets

HiCel™ Spheres

GradesASTM MeshMicrons (μm)Specifications
HiCel™ Spheres 100014-181000-1400Water Insoluble
HiCel™ Spheres 70018-25710-1000For organic solvent free API coating
HiCel™ Spheres 50025-35500-710Small Particle sized Spheres
HiCel™ Spheres 35035-45355-500Small with high robustness
HiCel™ Spheres 20045-70200-355The smallest sized spheres for almost
all APIs suitable for all PPIs (e.g.
Proton pump inhibitor)

Contact:

Corporate Office

Phone: +9140 40114874 / 75 / 76

[email protected]

 

Sigachi US

Phone: +1 443-417-1577 Ext 101

[email protected]

Sigachi MEA

Phone: +971521713505

[email protected]

SIGACHI

 

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