Non-aqueous formulations for ram and screen extrusion-spheronisation

The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a series of pastes using a ram as well as a laboratory…

News on Pharma Excipients

New Possibilities for Pharmaceutical Excipients Analysis

An alternative method for the determination of total chlorine content in hydroxypropyl cellulose (HPC) was applied, combining a recently developed system based on a combustion step followed by pyrohydrolysis reaction. Using this approach it was feasible the determination of total chlorine by…

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Excipient Basics

“Pharmaceutical excipients are substances other than the active pharmaceutical ingredient (API) that have been appropriately evaluated for safety and are intentionally included in a drug delivery system.”

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Excipients for Direct Compression

There is a wide range of excipients for direct compression with different functions available in the market.We put together an initial overview as a list of products available for download and commenting.

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