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Biopharma

Rationally designed negatively charged lipid nanoparticles reduce systemic reactogenicity of mRNA vaccines while preserving immunogenicity

15. November 2026

Abstract Messenger RNA (mRNA) vaccines have emerged as versatile platforms for the prevention of infectious diseases and therapeutic cancer vaccination. However, strong reactogenicity remains a key challenge, with severe adverse...

News

Amorphous Solid Dispersions as Non-Equilibrium Materials

Abstract An amorphous solid dispersion is a molecular glass that the pharmaceutical literature specifies as though it were a solution:...

15. November 2026

Biopharma

Uncovering the lymphatic uptake, pharmacokinetics, and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection

Abstract Lipid nanoparticle (LNP) formulations have enabled the in vivo delivery of messenger ribonucleic acid (mRNA) vaccines and therapeutics yet...

15. November 2026

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