Polymer degradation induced drug precipitation in PLGA implants – Why less is sometimes more
Nifedipine and nicardipine loaded PLGA extrudates have a great potential to prevent cerebral vasospasms after subarachnoid hemorrhage or surgical clipping of aneurysm. A constant release over approx. two weeks is desired. Although in vivo studies on humans have been reported, there is limited knowledge about the release kinetics and the underlying…
News on Pharma Excipients
Lyophilized liposome-based parenteral drug development
Given the successful entry of several liposomal drug products into market, and some with decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to overcome certain limitations of traditional drug delivery, especially for toxic and biologic drugs. This experience has…
Pharma Excipients Poster Award
Pharma Excipients Poster Award 2018: Check the winners
We are very excited to announce the winners of the 2018 Pharma Excipients Poster Award!
With this poster award we wanted to increase the visibility of all the work put into preparation of pharmaceutical and excipient posters for the different congresses, share this knowledge and award the 3 best…
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Excipient Basics
“Pharmaceutical excipients are substances other than the active pharmaceutical ingredient (API) that have been appropriately evaluated for safety and are intentionally included in a drug delivery system.”
Excipients for Direct Compression
There is a wide range of excipients for direct compression with different functions available in the market.We put together an initial overview as a list of products available for download and commenting.
News on Binders
Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs
Food induced viscosity in the gastrointestinal tract is reported to reduce the bioavailability of tablets containing BCS class 3 drugs, mainly by retarding their disintegration and dissolution of the active pharmaceutical ingredient. The role of formulation factors in minimizing this negative food…
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