Pharma Excipients
Petrochemicals
3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in…
Abstract
The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy. The objective of this literature review is to highlight the…
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Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet…
Abstract
The development of a robust oral solid dosage form requires knowledge of all the sources of variation that could impact the dosage form’s performance and stability, in line with Quality-by-Design (QbD). This requires a deep understanding of the relationships between raw material…
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Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Benchmarking pharmaceutical quality and manufacturing costs of 3D printing against conventional…
Abstract
Background: Modification of commercially available medicine, e.g. splitting or dissolving of tablets or pharmacy compounding, is current clinical practice when desired oral dosage forms are unavailable. These practices are defined as conventional pharmacy compounding techniques and are…
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Explainable artificial neural network as a soft sensor to predict the moisture content in a…
Abstract
The application of artificial neural networks (ANNs) has the potential to fundamentally change the pharmaceutical industry, making manufacturing more agile, robust, efficient and reliable. Although ANNs’ application as data-driven soft sensors has a particular potential, the black-box…
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The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary…
Abstract
Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to their outstanding success in applications including the COVID-19 vaccines and the siRNA therapeutic Onpattro®. As LNPs consist of different lipids, the lipid…
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Controlled release of amitriptyline via the transdermal route using SmartReservoirs and…
Abstract
SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This significantly improves the solubility of poorly soluble drugs, which…
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Poorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in…
Abstract
The incorporation of poorly soluble active ingredients, which make up the majority of the molecules in development, into fixed-dose combination (FDC) products can be an efficient method to improve the pharmacokinetic properties of these compounds, as well as reduce the side effects and…
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Assessment of leachables and extractables in “super-swelling” hydrogel-forming microarray patches
Abstract
Hydrogel-forming microarray patches (MAPs) offer a minimally invasive platform for transdermal drug delivery, enabling systemic absorption of active pharmaceutical ingredients. Unlike dissolving MAPs, which deposit their entire polymer matrix into the skin, hydrogel-forming MAPs remain…
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Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Abstract
The safety of repeated microarray patch (MAP) application is crucial for its development as an innovative drug delivery platform. This study is the first to assess the safety of repeated applications of hydrogel-forming, dissolving, and implantable MAPs over four weeks using miniature…
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