Pharma Excipients
Flavour / Flavor
Formulation and Evaluation Oral Dispersible Tablets of Vibegron
Abstract
In the present work, taste masking of Vibegron was carried out by using strong cation exchange resin tulsion 344. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant.…
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Evaluation of azithromycin–resin suspension designed for taste-masking and sustained-release
Abstract
Purpose: To prepare azithromycin (AZI) sustained-release suspension containing AZI-coated microcapsules (AZI-CM) impregnated with AZI-drug resin complex (AZI-DRC), in order to mask the bitter taste of AZI and improve the oral compliance of patients.
Methods: The AZI-DRC was prepared…
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Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and…
Abstract
Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood–brain barrier with effective therapies. ONC201 (dordaviprone) shows promises in inducing apoptosis in cancer cells but…
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Taste Masking Challenge of 155 Active Pharmaceutical Ingredients
Abstract
Regulations in the US and EU require and incentivize the development of palatable, age-appropriate medicines for children. However, the taste masking challenge of new drug actives is generally unknown, making development of palatable drug products extremely difficult. To develop palatable…
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3D printed personalized therapies for pediatric patients affected by adrenal insufficiency
ABSTRACT
Background
Adrenal insufficiency is usually diagnosed in children who will need lifelong hydrocortisone therapy. However, medicines for pediatrics, in terms of dosage and acceptability, are currently unavailable.
Research design and methods
Semi-solid extrusion (SSE) 3D printing…
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Aroma and Flavor in Product Development: Characterization, Perception, and Application – Part…
Characterization, Perception, and Application
See the new book, edited by Rajnibhas Sukeaw Samakradhamrongthai. This guide provides essential insights into perception, formation, and development, enabling developers to enhance food items' organoleptic qualities and thereby provide consumers with an…
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Aroma and Flavor in Product Development: Characterization, Perception, and Application – Part…
Characterization, Perception, and Application
See the new book, edited by Rajnibhas Sukeaw Samakradhamrongthai. This guide provides essential insights into perception, formation, and development, enabling developers to enhance food items' organoleptic qualities and thereby provide consumers with an…
Read More...
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Encapsulation of bioactive compounds in foods for diabetics – sources, encapsulation…
Diabetes is a metabolic disorder characterized by hyperglycemia and is a disease with an increasing prevalence. Hyperglycemia triggers abnormalities in the metabolism of carbohydrates, proteins, fats, and can cause complications. This disease is caused by poor lifestyles, such as food consumption…
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Development and Assessment of Orally Disintegrating Tablet Containing Montelucast Sodium
Abstract
Montelukast sodium is widely used in treatment of asthma and other allergic disorders. The Montelukast sodium is a water insoluble drug but need quick action. So we planned a mouth dissolving tablet of Montelukast sodium. Further we evaluated functionality of co-processed super…
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Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these…
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