Nanotechnology for excipients (or “nanotech”) is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The National Nanotechnology Initiative defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.
Pharma Excipients
Nanotechnology
Characterization of enteric-coated capsules filled with colchicine loaded zein nanoparticles for…
Abstract
Aim
In this study, we developed a dual pH and time-dependent formulation for targeted colonic release, aiming at minimizing adverse effect and enhancing anticancer efficacy of colchicine in the treatment of colorectal cancer.
Article highlights
The findings of this study…
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Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects
Abstract
Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals. Initially targeting contraception and local effects from…
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Excipient nanoparticles as cancer therapeutics: Mechanistic actions, delivery and manufacturing…
Abstract
Excipients, conventionally defined as inactive additives, are potential anti-cancer therapeutics at nanoscale against various cancers. This mini-review highlighted nano-excipient potential as anti-cancer therapeutic based on recent literature (2022–2025). Metal/metal oxide nanoparticles…
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Complex Ophthalmic Dosage Forms: Advances in Biomedical Applications and Future Perspectives
Complex Ophthalmic Dosage Forms: Advances in Biomedical Applications and Future Perspectives
See the new book, edited by Neelesh Kumar Mehra. The aim of the proposed book is to provide exhaustive information about the fundamental concepts, theory and applications of the simple and complex…
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Emerging for non-invasive heparin delivery systems: recent advances, barriers, solutions, and…
Abstract
Nowadays, the use of unfractionated low molecular weight heparins through intravenous and subcutaneous routes has been limited by several delivery challenges. These include pharmacological activity fluctuations, bleeding issues, and numerous manufacturing restrictions. To address these …
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Feasibility of Hot Melt Extrusion in Converting Water-Based Nanosuspensions into Solid Dosage Forms
Abstract
Aim: In addition to numerous benefits provided by nanosuspensions (NSs) (e.g., enhanced saturation solubility, increased area for interaction with fluids), they suffer from major stability, handling and compliance issues. To overcome these challenges, we evaluated the feasibility of hot…
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Formulation and Characterization of Novel Oral pH-Sensitive Electrospun Nanofibers for Boosting…
Abstract
Sulpiride, (a model class IV drug) is a central dopamine antagonist, that is commonly used in the treatment of various psychiatric and gastrointestinal conditions. However, its poor aqueous solubility and low oral bioavailability (20-30%) limit its therapeutic efficacy. Electrospun…
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Development, characterization, and in vitro evaluation of poly(ethylene…
Abstract
Rapamycin holds significant therapeutic potential for various diseases; however, its clinical application is limited by several formulation challenges, primarily its extremely low aqueous solubility (2.6 μg/mL). To address this, nanoparticle-based delivery systems have emerged as a…
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A drug delivery perspective on nanotechnology-based topical therapeutics for inflammatory skin…
Abstract
Inflammatory skin diseases are chronic conditions that significantly affect patients’ skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe…
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