Nanotechnology for excipients (or “nanotech”) is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The National Nanotechnology Initiative defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.
Pharma Excipients
Nanotechnology
A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory…
Abstract
Poor aqueous solubility of preexisting and emerging drug molecules is a common issue faced in the field of pharmaceutics. To address this, particle size reduction techniques, including drug micro- and nanonisation have been widely employed. Nanocrystals (NCs), drug particles with…
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Solid Self Nano-Emulsifying Drug Delivery System of Dasatinib: Optimization, In-vitro, Ex-vivo and…
Abstract
Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST was formulated.
Methods: I-optimal mixture design was used for optimization of DST-loaded SNEDDS using…
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PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,abdominal pain, and fluctuations in plasma levels. The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential…
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Acidified sucralfate encapsulated chitosan derivative nanoparticles as oral vaccine adjuvant…
Abstract
Oral vaccines are generally perceived to be safe, easy to administer, and have the potential to induce both systemic and mucosal immune responses. However, given the challenges posed by the harsh gastrointestinal environment and mucus barriers, the development of oral vaccines…
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Drug Loading Methods and Kinetic Release Models Using of Mesoporous Silica Nanoparticles as a Drug…
Abstract
Oral drug administration remains one of the most convenient routes due to its Simplicity, high patient compliance, and cost-effectiveness. However, many medicinal products available on the market exhibit poor water solubility, which adversely affects the dissolution rate of drugs in…
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Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier…
Abstract
Purpose
The purpose of this study was to formulate and evaluate nanostructured lipid carriers (NLCs) of the poorly water soluble anticancer drug Flutamide.
Methods
Flutamide-loaded NLCs were formulated by the melt-emulsification ultrasonication method using solid lipid (Precirol ATO…
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Evaluation of Anticancer Efficacy of D-α-Tocopheryl Polyethylene-Glycol Succinate and Soluplus®…
Abstract
Purpose: Ovarian cancer has the highest mortality rate and lowest survival rate among female reproductive system malignancies. There are treatment options of surgery and chemotherapy, but both are limited. In this study, we developed and evaluated micelles composed of D-α-tocopheryl…
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Anticancer drug delivery: Investigating the impacts of viscosity on lipid-based formulations for…
Abstract
Pulmonary drug delivery via aerosolization is a non-intrusive method for achieving localized and systemic effects. The aim of this study was to establish the impact of viscosity as a novel aspect (i.e., low, medium and high) using various lipid-based formulations (including liposomes…
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Redispersible dry powders containing nanoencapsulated curcumin increase its antioxidant activity
The present study aimed to develop redispersible spray-dried powders containing curcumin-loaded Eudragit® L100 nanocapsules and evaluate their physicochemical properties and antioxidant potential. The spray drying process showed a yield of over 85%, low residual moisture content (<2%), and all…
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Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin…
Skin carcinoma remains one of the most widespread forms of cancer, and its global impact continues to increase. Basal cell carcinoma, melanoma, and squamous cell carcinoma are three kinds of cutaneous carcinomas depending upon occurrence and severity. The invasive nature of skin cancer, the limited…
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