Nanotechnology

Abstract Background Ritonavir is an anti-retroviral protease inhibitor to treat HIV, AIDS infections. Methods The RN-SLNs were prepared by using hot homogenization followed ultrasonication method and optimized by using a two-factor, three-level central composte design (CCD). The independent…
Read More...

Novel Carrier Systems for Targeted and Controlled Drug Delivery See the new book, edited by Awesh K. Yadav, Keerti Jain. Here the general concepts and new research results on targeted and controlled drug delivery are examined. Challenges and future directions in controlled drug delivery are…
Read More...

Abstract Poor solubility of many drugs, with ensuing low bioavailability, is a big challenge in pharmaceutical development. Nanosuspensions have emerged as a platform approach for long-acting injectables and solid dosages that enhance drug bioavailability. Despite improvements in nanosuspension…
Read More...

Abstract Lidocaine (LID), frequently used in dermal applications, is a nonpolar local anesthetic agent that is practically insoluble in water. The main aim of this study is to develop the nanosuspension formulation of LID using the design of experiments (DoE). The improved solubility and…
Read More...

Abstract Herein, a new type of controlled-release system is fabricated using polycaprolactone (PCL) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the creation preparation study. They include doxorubicin (DOX), a standard chemical for chemotherapy, and curcumin, part of the plant…
Read More...

Abstract S-Adenosylmethionine (SAMe) is a crucial endogenous molecule in vital biochemical processes such as DNA, RNA, and protein methylation. It has been found beneficial in the treatment of liver disease, osteoarthritis, and particularly depression. However, SAMe's therapeutic potential is…
Read More...

Abstract This study focuses on the formulation, optimization, and characterization of a water-in-oil (W/O) Pickering emulsion (PE) containing capecitabine (CAP), which is self-stabilized using polysarcosine (Psar) nanoparticles (NPs), to create a topical treatment for squamous cell carcinoma…
Read More...

Abstract Background: Phosphodiesterase-4 is an enzyme that regulates immune responses and contributes to the development of psoriasis. Dipyridamole and roflumilast function as phosphodiesterase-4 inhibitors, reducing pro-inflammatory cytokine expression. The aim was to evaluate the anti-psoriatic…
Read More...

Abstract Oral absorption is limited for many small-molecule drugs due to their poor aqueous solubility as well as, for some, poor membrane permeation. One such is levosulpiride (LSP), used to treat psychotic and other conditions. The present study aims to explore the effect of nanostructured…
Read More...

Abstract Background Rivastigmine (RT), exhibits low oral availability (40%) and high hepatic first-pass (36%). Circumventing the blood-brain barrier-related convolutions for successful brain delivery following intranasal administration prerequisites nano-size particles with high drug loading due…
Read More...