Nanotechnology for excipients (or “nanotech”) is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The National Nanotechnology Initiative defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.
Pharma Excipients
Nanotechnology
PLGA/TPGS nanoparticles for docetaxel delivery: the pegylation effect on nanoparticle…
Abstract
Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context, the development of polymeric nanoparticles offers advantages…
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Unveiling the Potential of Nanosuspension Formulation Strategy for Improved Oral Bioavailability of…
Abstract
Gefitinib (GB), an oral tyrosine kinase inhibitor suffers major setbacks in clinical application due to limited aqueous solubility leading to poor oral bioavailability. Nanosuspension serves as a promising formulation strategy to overcome the above-mentioned drawbacks. Hence, the present…
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Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: A novel approach for…
High intraocular pressure (IOP) is the main risk factor for glaucoma progression. Acetazolamide (AZM) presents a potent IOP-lowering effect but is only administered orally due to its low aqueous solubility and ocular permeability. This study aimed to develop AZM nanocrystals (AZM-NC) as an…
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Trans-Resveratrol-Loaded Nanostructured Lipid Carrier Formulations for Pulmonary Drug Delivery Using…
Abstract
Aerosolization is a non-invasive approach of delivering drugs for both localized and systemic effects, specifically pulmonary targeting. The aim of this study was to deliver trans-resveratrol (TR) as an anti-cancer drug entrapped in a new generation versatile carriers nanostructured lipid…
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Nanostructured Strategies for Melanoma Treatment—Part II: Targeted Topical Delivery of Curcumin via…
Abstract
Background/Objectives: Curcumin (CUR) is a natural compound with notable antitumor properties but faces limitations in topical applications due to poor aqueous solubility, instability, and insufficient skin penetration. To overcome these challenges, a nanomicellar formulation…
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Orally disintegrating films based on pullulan and HPMC with carbopol-coated mucoadhesive…
Abstract
Dual-pattern drug release systems are a new type of drug delivery system designed to achieve both immediate and sustained drug release. This study developed a dual-pattern system by combining orally disintegrating films (ODFs) with mucoadhesive nanoparticles (NPs). The NPs were made from…
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Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and…
Abstract
This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol using mesoporous silica nanoparticles (MSNs). The liquid self-nanoemulsifying drug delivery system (L-SNEDDS) consisted of carvedilol, Peceol,…
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Amphotericin B PLGA nanoparticles loaded dissolving microneedle patches in treating cutaneous fungal…
Abstract
Cutaneous fungal infections pose a significant health challenge, particularly in deeper skin layers where topical treatments are ineffective. Amphotericin B (AmB) is the gold standard for treating fungal infections, but its poor solubility limits its transdermal delivery. In this work, AmB…
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Preparation of polyvinyl alcohol/Pullulan nanofibers and Eudragit® S100/polyvinyl alcohol/Pullulan…
Abstract
Probiotics, which play a crucial role in regulating intestinal homeostasis and maintaining host health, face significant challenges in maintaining their survival rate after processing, storage, and oral administration, posing a substantial hurdle in probiotic use. In this study,…
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Formulation and Development of Posaconazole Loaded Controlled Release Nanosponge Topical Gel for the…
Abstract
Purpose
The main purpose of this study is to synthesize posaconazole as a nanosponge device to evaluate its antifungal potential, specifically for the treatment of cutaneous candidiasis caused by the Candida albicans fungus.
Methods
Posaconazole inhibits fungi by acting on their cell…
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