Pharma Excipients
Solubilizer
The basics of intestinal permeation – What is poor intestinal permeability?
Developing a formulation for the oral route is a long and complex journey in which the API (Active Pharmaceutical Ingredient) characteristics are of an utmost importance. Amidon et al. were the first, in 1995, to suggest a classification system for APIs, in which they correlated in vitro drug…
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The application of cyclodextrins in drug solubilization and stabilization of nanoparticles for drug…
Abstract
Nanoparticles (NPs) have gained significant attention in recent years due to their potential applications in pharmaceutical formulations, drug delivery systems, and various biomedical fields. The versatility of colloidal NPs, including their ability to be tailored with various components…
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Enhanced Ocular Drug Delivery of Dexamethasone Using Chitosan-Coated Soluplus® Based Mixed Micellar…
Abstract
Background: This study introduces a novel dexamethasone (DEX) mixed micellar system (DEX-MM) using Soluplus® and Pluronic F-127 (PF127) to enhance ocular drug delivery. The enhancement of ocular application properties was achieved by creating a chitosan-coated DEX-MM (DEX-CMM), which…
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Soluplus–TPGS Mixed Micelles as a Delivery System for Brigatinib: Characterization and In Vitro…
Abstract
Lung cancer is a major public health concern, with a high incidence and fatality rate. Its treatment is very difficult, as it is mostly diagnosed in advanced stages. Non-small cell lung carcinoma (NSCLC) is the major form of lung carcinoma that persists. Brigatinib (BGT), a powerful…
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Pharmaceutical lactose, in what form and for what use?
Pharmaceutical lactose has been used since the 19th century, and has carved out a place for itself in the pharmaceutical industry, becoming a key excipient now found in 60% to 70% of oral medicines. Lactose is the milk sugar and highly present in the whey, a by-product of the cheese production.…
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Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is…
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Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to…
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Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in…
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Efficient Improvement of Eugenol Water Solubility by Spray Drying Encapsulation in Soluplus® and…
Abstract
Herein, we present an elegant and simple method for significant improvement of eugenol water solubility using the polymers Soluplus® and Lutrol F 127 as carriers and spray drying as an encapsulation method. The formulations were optimized by adding myo-inositol—a sweetening agent—and…
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Optimizing Production, Characterization, and In Vitro Behavior of Silymarin–Eudragit Electrosprayed…
Abstract
Inflammatory Bowel Disease (IBD) is a chronic condition that affects approximately 1.6 million Americans. While current polyphenols for treating IBD can be expensive and cause unwanted side effects, there is an opportunity regarding a new drug/polymer formulation using silymarin and an…
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