Pharma Excipients
Solubilizer
Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and…
Abstract
This study presents an innovative approach that utilizes polymers with different topologies and properties as potential matrices for the poorly water-soluble active pharmaceutical ingredient piribedil (PBD). We investigated amorphous solid dispersions (ASDs) as well as micellar systems…
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Olmesartan Medoxomil Nanomicelle Using Soluplus for Dissolution Enhancement: Preparation, In-vitro…
Abstract
The antihypertensive medication olmesartan medoxomil (OLM) is pharmacologically selective angiotensin-II receptor antagonist. Pharmaceutically speaking, OLM is a class II medication (low solubility, high permeability) that is practically insoluble.Due to its extremely poor solubility,…
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Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Water-Soluble Formulations of Curcumin and Eugenol Produced by Spray Drying
Abstract
Background/Objectives: In this study, we present a green, scalable platform for the production of water-dispersible powders co-encapsulating the lipophilic bioactives curcumin (Cur) and eugenol (Eug) within the amphiphilic polymer Soluplus® (SP) via low-temperature spray drying.…
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Quercetin-Eudragit® polymer complexes with enhanced loading, solubility, stability, and…
Abstract
Aim
Quercetin is a natural dietary compound known for its potential to prevent chronic diseases. However, the translation of this success to humans is hindered due to quercetin’s poor oral bioavailability, attributed to its extremely low water solubility and permeability. These…
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Development and Characterization of α-Lipoic Acid Amorphous Solid Dispersion for Improved Oral…
Abstract
α-Lipoic acid (LA), a naturally occurring antioxidant and anti-inflammatory agent, has limited aqueous solubility and bioavailability which hinders its clinical application. To overcome these limitations, in this study, we have developed LA solid dispersion (LASD) using soluplus (SOL) to…
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Exploring mesoporous silica microparticles in pharmaceutical sciences: Drug delivery and therapeutic…
Abstract
Nanotechnology has revolutionised pharmaceutical sciences, with mesoporous silica nanoparticles (MSNs) extensively studied as drug carriers. However, their clinical translation is hindered by challenges such as toxicity, tumour accumulation, and uncontrolled endocytosis. Mesoporous silica…
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Enhanced Delivery of Posaconazole Using Novel Solid Self Nanoemulsifying Drug Delivery System: In…
Abstract
Purpose
Posaconazole (POS) is widely used as an antifungal agent effective against Candida infections. Because of its very low water and high fat solubility, it falls under the Biopharmaceutics Classification System (BCS) Class II. It showed considerable differences in absorption rates…
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Comparative study of Hot-Melt Extrusion, spray drying, and KinetiSol® processing to formulate a…
Abstract
Fenbendazole (FBZ), a benzimidazole-carbamate anthelmintic, shows promising chemotherapeutic properties. However, it is a poorly water-soluble molecule, leading to low and variable oral bioavailability. This study investigated hot-melt extrusion (HME), spray drying, and KinetiSol…
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Study of the Influence of Pharmaceutical Excipients on the Solubility and Permeability of BCS Class…
Abstract
Most novel active pharmaceutical ingredients have low water solubility; therefore, solubility-enhancing methods are applied. The aim of the present investigation is to study the impact of nine commonly used pharmaceutical excipients (fillers, surfactants, cyclodextrins, polymers) on…
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