Pharma Excipients
Solubilizer
Applications of Polysorbates – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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Applications of Sorbitan Esters – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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Sustained-Release Solid Dispersions of Fenofibrate for Simultaneous Enhancement of the Extent and…
Abstract
Background/Objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of…
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Decades of expertise in the field of application technology – The Product Development (PD)…
IOI Oleo GmbH is known for its high-quality oleochemical specialities and the technical advice it provides on the use of its products. Thanks to its diversity and longstanding reliability, the product portfolio is used in the pharmaceutical, care, nutrition and technical applications sectors. The…
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Effects of micellar media on the bioavailability, solubility, and stability of curcumin
Abstract
Curcumin (CUR), a polyphenolic pigment of turmeric, -possess biological and medicinal properties. Regardless of having a wide range of therapeutic applications, CUR’s poor bioavailability, owing to its meagre solubility and stability, limits its application from being used as a…
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Influence of polymer and surfactant-based precipitation inhibitors on supersaturation-driven…
Abstract
There is a growing pharmaceutical interest in supersaturated lipid-based formulations (Super-LbF) as an innovative strategy to enhance drug loading capacities while simultaneously reducing pill burden. This approach involves increasing the drug concentration above its equilibrium…
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Nanostructured lipid carriers as a strategy to enhance oral levosulpiride delivery: An in vitro and…
Abstract
Oral absorption is limited for many small-molecule drugs due to their poor aqueous solubility as well as, for some, poor membrane permeation. One such is levosulpiride (LSP), used to treat psychotic and other conditions. The present study aims to explore the effect of nanostructured…
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Treatment of ulcerative colitis via the in situ restoration of local immune and microbial…
Abstract
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease, and conventional treatments, such as anti-inflammatory medications and surgery, often prove inadequate due to frequent recurrences and various complications. To alleviate patient suffering, there is an urgent need for a…
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Effect of polyoxylglycerides-based excipients (Gelucire®) on ketoprofen amorphous solubility and…
Abstract
Polyoxylglycerides-based solid mixtures, commercially known as Gelucire®, are excipients commonly used for bioavailability improvement of poorly water-soluble drugs. However, their effect on solutions containing hydrophobic drugs above crystalline solubility has not yet been explored.…
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Patent on controlled release formulations of highly lipophilic physiologically active substances
The patent application US20240139215A1 focuses on the development of controlled release formulations for highly lipophilic physiologically active substances, such as cannabinoids. These substances tend to have high lipid solubility (log P of 4 or more), making them difficult to deliver in a…
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