Pharma Excipients
Solubilizer
Soluplus® as Promising Polymer for Topical Film Forming Solid Solutions of Betamethasone…
This poster was presented at the PBP World Meeting 2024 in Vienna:
BACKGROUND & INTRODUCTION
Topical film-forming solutions (FFSs) represent an innovative form of sustained release dermatological dosage forms. They can be applied to the skin as solutions, gels or sprays. After evaporation of…
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Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl…
ABSTRACT
The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a non-ionic surfactant. Phase solubility studies suggested…
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Enabling superior drug loading in lipid-based formulations with lipophilic salts for a brick dust…
Lipid-based formulations (LbFs) are an extensively used approach for oral delivery of poorly soluble drug compounds in the form of lipid suspension and lipid solution. However, the high target dose and inadequate lipid solubility limit the potential of brick dust molecules to be formulated as LbFs.…
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Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of…
Abstract
The aim of this study was to determine the drug loading capacity of phosphatidylcholine-based formulations for four poorly water-soluble drug substances (clofazimine, fenofibrate, artemether, cannabidiol). Two self-dispersing lipid formulations were investigated, which consisted of soybean…
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Enhancing Drug Efficacy: Gattefossé’s Expertise in Excipient Selection
About our company
The Gattefossé Group is a community of employees, all driven by a dual mission: the performance of its products and the personalized support to its customers. Gattefossé develops, manufactures and sells cosmetic ingredients and pharmaceutical excipients of natural origin for…
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Soluplus® nanomicelles enhance IgG neutralizing properties against Shiga toxin type 2
Shiga toxin (Stx) is the main virulence factor of Stx-producing Escherichia coli, a pathogen responsible for developing Hemolytic Uremic Syndrome. Nowadays, no specific treatment exists for this disease, and nanomicelles may be an excellent platform for the delivery of specific compounds, including…
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Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized…
Abstract
The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data matrix-generator software specifically focused on the healthcare…
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Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized…
Abstract
Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application of liposomal pMDIs…
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Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations
Abstract
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for oral administration since non-aqueous…
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SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.
SEPITRAP™ is both a solid solubilizer and a compression agent.…
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