Asahi Kasei is the leading manufacturer and supplier of functional excipients such as microcrystalline cellulose (MCC) in Japan. We leveraged five decades of experience and our proprietary morphology design technology to create high-performance MCC products with unique properties.
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The commitment of the Asahi Kasei Group
To do all that we can in every era to help the people of the world make the most of life and attain fulfillment in living. Since our founding, we have always been deeply committed to contributing to the development of society, boldly anticipating the emergence of new needs.
This is what we mean by “Creating for Tomorrow.”
With their superior flowability and compactibility, our Ceolus™ high functional grades bring formulation design and tabletting efficiency to a new level, particularly for high dose, small tablet, and low-compactibility drug formulations. Celphere™, our MCC spherical cores allow the combination of incompatible APIs in one tablet, achieve robust release profile and improve the acceptability of products. Our pregelatinized starch PC-10 can be applied for protection of moisture sensitive APIs.
We, Asahi Kasei started MCC production in 1970 in Nobeoka, a city in the South edge of Japan, which is the birthplace of Asahi Kasei group.
- Since the 2000s, we have been continuously developing MCC products that have unique performance which derives from our patented unique morphology design.
- Our products have helped customers with technical challenges among several product development stages such as lab, scale-up, and production.
- We will keep with our commitment to develop high performance and/or highly functional products that will benefit our customers
Nitrosamine Reduction Solutions – Ceolus™ MCC Keeps Nitrites to 0.1ppm
Asahi Kasei’s Ceolus™ MCC provides nitrite concentrations of 0.1 ppm or less across our current primary product lines. Test results confirming these levels are provided in every Certificate of Analysis.
Why Choose Ceolus™ MCC for Nitrosamine Management?
・Verified Nitrite Levels ≤ 0.1 ppm Guaranteed in Specification
・Documented in Certificate of Analysis
・Consistent Testing Indicates Low Nitrite Concentration
・Trusted Performance in 400+ Projects for Nitrosamine Risk Reduction
Ceolus™KG – High compactible MCC
Benefits
- Faciliate high dosage formulation
- Lower tablet friability
- Realize low pressure tableting
- Prevent sticking and capping
- Suitable for Orally Disintegrating Tablet (ODT)
- Suitable for Multi Unit Particulate System (MUPS)
- Bilayer tablets
Recommended production methods
- Direct Compression
- Dry Granulation (Roller Compaction)
- Wet Granulation (Extra Addition)
Features
- Fibrous Particles with extremely large length-diameter ratio
Performance
- High Compactibility
Find all Ceolus™ SEM images here
Ceolus™UF – High flowable and compactible MCC
Benefits
- Improve poorly flowable formulations
- Fast disintegration and dissolution with sufficient hardness
- Prevent segregation and over-lubrication
- Facilitate high speed tableting
- Optimized for tableting of poorly compactable and flowable formulations
Recommended production methods
- Direct Compression
- Wet Granulation (Intra- and extra- addition)
Performance
UF-702
- Super-flowability
- High swellability
- Adsorption on the particle surface
UF-711
- Well-balanced compactibility and flowability
Find all Ceolus™ SEM images here
Ceolus™PH – Standard grade with high quality
Ceolus™ PH covers every standard grade with high quality.
SEM images of particles
General properties
| Grade | Average Particle Size(μm) |
Bulk density (g/cm3) | Repose Angle(°） | Loss on Drying(%) |
Water absorption (%) |
Oil absorption (%) |
|
|---|---|---|---|---|---|---|---|
| Ceolus™ PH Standard grade with high quality |
PH-101 | 50 | 0.29 | 45 | 2.0-6.0 | 200 | 120 |
| PH-102 | 90 | 0.30 | 42 | 2.0-6.0 | 200 | 140 | |
| PH-200 | 170 | 0.35 | 36 | 2.0-6.0 | 200 | 140 | |
| PH-301 | 50 | 0.41 | 41 | 2.0-6.0 | 150 | 90 | |
| PH-302 | 90 | 0.43 | 38 | 2.0-6.0 | 170 | 100 | |
| PH-F20JP | 20 | 0.23 | ≧ 60 | ≦ 7.0 | 220 | 100 |
Celphere™– MCC seed core
Features
- 100% MCC sphere
- Smooth surface
- Excellent sphericity
- Narrow size distribution
Key Performance
- High mechanical strength
- Moderate water absorption
- Low reactivity
- Stable particle property
Benefits
- Tolerant with high stress and coating machine varieties
- Reduce aggregation
- Yield improvement in coating
- Suitable for controlled released formulations like MUPS
| Grade | Particle size range (μm) | Sphericity | Bulk density (g/ｍL) | Water absorption (%) |
|---|---|---|---|---|
| CP-102 | 106-212 | ≥ 0.9 | 0.83 | 100 |
| CP-203 | 150-300 | ≥ 0.9 | 0.87 | 100 |
| CP-305 | 300-500 | ≥ 0.9 | 0.97 | 110 |
| CP-507 | 500-710 | ≥ 0.9 | 0.97 | 70 |
| CP-708 | 710-850 | ≥ 0.9 | 0.93 | 65 |
