Asahi Kasei – Ceolus™ & Celphere™

Asahi Kasei ceolus and celphere header

Asahi Kasei is the leading manufacturer and supplier of functional excipients such as microcrystalline cellulose (MCC) in Japan. We leveraged five decades of experience and our proprietary morphology design technology to create high-performance MCC products with unique properties.

The commitment of the Asahi Kasei Group

To do all that we can in every era to help the people of the world make the most of life and attain fulfillment in living. Since our founding, we have always been deeply committed to contributing to the development of society, boldly anticipating the emergence of new needs.

This is what we mean by “Creating for Tomorrow.”

With their superior flowability and compactibility, our CEOLUS high functional grades bring formulation design and tabletting efficiency to a new level, particularly for high dose, small tablet, and low-compactibility drug formulations. CELPHERE, our MCC spherical cores allow the combination of incompatible APIs in one tablet, achieve robust release profile and improve the acceptability of products. Our pregelatinized starch PC-10 can be applied for protection of moisture sensitive APIs.

bilayer tabletsWe, Asahi Kasei started MCC production in 1970 in Nobeoka, a city in the South edge of Japan, which is the birthplace of Asahi Kasei group.

  • Since the 2000s, we have been continuously developing MCC products that have unique performance which derives from our patented unique morphology design.
  • Our products have helped customers with technical challenges among several product development stages such as lab, scale-up, and production.
  • We will keep with our commitment to develop high performance and/or highly functional products that will benefit our customers

CEOLUSKG – High compactible MCC

ceolus kg 1000 sem image
Ceolus™ KG-1000

Benefits

  • Faciliate high dosage formulation
  • Lower tablet friability
  • Realize low pressure tableting
  • Prevent sticking and capping
  • Suitable for Orally Disintegrating Tablet (ODT)
  • Suitable for Multi Unit Particulate System (MUPS)
  • Bilayer tablets
ceolus kg 802 sem image
Ceolus™ KG-802

Recommended production methods

  • Direct Compression
  • Dry Granulation (Roller Compaction)
  • Wet Granulation (Extra Addition)

Features

  • Fibrous Particles with extremely large length-diameter ratio

Performance

  • High Compactibility

Find all CEOLUSSEM images here

Asahi Kasei Ceolus graph


CEOLUSUF – High flowable and compactible MCC

CEOLUS™ UF-702 sem image
CEOLUS™ UF-702

Benefits

  • Improve poorly flowable formulations
  • Fast disintegration and dissolution with sufficient hardness
  • Prevent segregation and over-lubrication
  • Facilitate high speed tableting
  • Optimized for tableting of poorly compactable and flowable formulations
CEOLUS™ UF-711 sem image
CEOLUS™ UF-711

Recommended production methods

  • Direct Compression
  • Wet Granulation (Intra- and extra- addition)

Performance

UF-702

  • Super-flowability
  • High swellability
  • Adsorption on the particle surface

UF-711

  • Well-balanced compactibility and flowability

Find all CEOLUSSEM images here


CELPHERE– MCC seed core

CP - 102 - CP 305 SEM imageFeatures

  • 100% MCC sphere
  • Smooth surface
  • Excellent sphericity
  • Narrow size distribution

CP 507 - 708 SEM imageKey Performance

  • High mechanical strength
  • Moderate water absorption
  • Low reactivity
  • Stable particle property

Benefits

  • Tolerant with high stress and coating machine varieties
  • Reduce aggregation
  • Yield improvement in coating
  • Suitable for controlled released formulations like MUPS
GradeParticle size range (μm)SphericityBulk density (g/mL)Water absorption (%)
CP-102106-2121.20.83100
CP-203150-3001.10.87100
CP-305300-5001.10.97110
CP-507500-7101.20.9770
CP-708710-8501.20.9365

Asahi Kasei: Creating for tomorrow


Brochures

Asahi Kasei_General Brochure_1
Asahi Kasei general brochure
Reducing Friability of Tablets for Film Coating by Using KG-1000
Reducing Friability of Tablets for Film Coating by Using KG-1000
ceolus leaflet
CEOLUS™ leaflet
Preventing the tableting issues and making very hard tablet of high dose Metformin HCl in direct compression using the most highly compactible microcrystalline cellulose (MCC) CeolusTM KG
Preventing the tableting issues and making very hard tablet of high dose Metformin HCl in DC

Contact

Asahi Kasei Corporation
Functional Additives Division
1-1-2 Yurakucho, Chiyoda-ku, Tokyo 100-0006 JAPAN
Phone:+81 3 6699 3361

Asahi Kasei Europe GmbH
Fringsstraße 17, Düsseldorf 40221 Germany
Phone:+49 211 3399 2082

Asahi Kasei America Inc.
800 Third Avenue, 30th Floor, New York, NY 10022 USA
Phone: +1 212 371 9900

Asahi Kasei India Pvt. Ltd.
The Capital 1502B, Plot No. C70 G Block, Bandra Kurla Complex Bandra(East),
Mumbai 400051 India
Phone: +91 22 6710 3962

Asahi Kasei (China) Co., Ltd.
8/F, One ICC, Shanghai International Commerce Centre, No.999 Huaihai Zhong Road,
Shanghai 200031 China
Phone: +86 21 6391 6111

Asahi Kasei Corp., Beijing Office
Suite 2008,Gemdale Plaza,91 Jianguo Road, Chaoyang District, Beijing, P.R.China
Phone: +86 10 6569 3939


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