Inorganic Chemicals

This work presents a system, in which machine vision combined with artificial intelligence-based image analysis was used to determine the component-based particle size distribution of pharmaceutical powder blends. The blends consisted of acetylsalicylic acid (ASA) and calcium hydrogen phosphate…
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Abstract Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors. However, the pharmacological interactions between these compounds remain incompletely understood. In…
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Abstract This study aims to decouple the effect of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, dwell time and strain rate were isolated from other parameters in the compaction cycle so that their independent contributions to…
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Abstract Solid forms transformations and new crystal structures of an active pharmaceutical ingredient (API) can occur due to various manufacturing process conditions, especially if the drug substance is formulated as a hydrate. The conversion between hydrate and anhydrate forms caused by changes…
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Abstract This study examines the influence of crospovidone (CP) manufacturer variability on the dissolution profiles of hydrochlorothiazide (HCTZ) tablets. Four CP batches from different manufacturers were characterized using pharmacopeial and physicochemical tests, including infrared absorption,…
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Abstract Targeting the development of 3D printed reservoir-like vaginal rings (VRs) intended to fulfill the needs of precision medicine, prototypes ensuring prolonged release of metronidazole (MTZ) were preliminary manufactured and tested. Indeed, this drug represents the first-line therapy…
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Abstract In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean…
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Introduction Axitinib (AXT), a second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR), is used in the treatment of advanced renal cell carcinoma (RCC). Despite its efficacy, AXT's clinical application is limited by its poor aqueous solubility and bioavailability,…
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Abstract Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Abstract Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing…
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