Pharma Excipients
Plasticizer
Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects
Abstract
Tablet coating with aqueous solvents represents a well-established environmentally sustainable alternative to coatings based on organic solvents. However, this practice requires a careful evaluation of potential quality issues, such as increased porosity and crack formation stemming from…
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Mastering the Softgel Encapsulation Process: A Deep Dive into Precision Manufacturing
Softgel capsules are a cornerstone of modern pharmaceutical and nutraceutical industries, offering consumers a seamless, easy-to-swallow solution that enhances bioavailability and ensures precise dosing. This article will examine the intricate processes involved in softgel encapsulation,…
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Understanding the effect of plasticizers in film coat materials on the physical stability of…
Abstract
Amorphous solid dispersions (ASDs) have been extensively utilized to improve the bioavailability of drugs that have low aqueous solubility. The influence of different excipients on the conversion of amorphous drugs into their crystalline forms in ASDs has been extensively researched.…
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Homogeneity and mechanical properties of orodispersible films loaded with pellets
Abstract
Orodispersible films (ODFs) have served as an emerging platform for the delivery of drugs in a convenient way. The production of ODFs with incorporated pellets may still be a challenging process due to problems to obtain proper homogeneity and deteriorating mechanical properties of the…
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The Role of Coatings and Plasticizers Compatibility in Stability of Advanced Gastro-resistant…
The gastro-resistant behaviour of solid self-emulsifying drug delivery systems (S-SEDDS) represents a significant and innovative advancement in delivering poorly soluble drugs. Due to the complexity of these systems and the liquid nature of SEDDS, thorough investigation is essential. This study…
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Materials masterclass: Plasticisers in amorphous solids (glasses)
In this video Pharma Drama aka Prof. Simon Gaisford explains why amorphous pharmaceuticals are so unstable when there's water around. It's because water is an excellent plasticiser, and speeds up the rate at which amorphous materials relax, ultimately leading to crystallisation. Plasticisers are…
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Modification of the Biorelevant Release Testing of Esophageal Applied Mucoadhesive Films and…
Abstract
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus. Biorelevant test systems such as EsoPeriDiss are essential for early…
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Deciphering the Role of Plasticizers and Solvent Systems in Hydrophobic polymer coating on…
Abstract
The type of plasticizer and the choice of solvent or co-solvents used for coating of a hydrophilic core can greatly impact the permeability, porosity, and mechanical strength of the polymer film. Although, Ethylcellulose (EC) is an old polymer, it is a polymer of choice for modifying the…
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Microencapsulation for the delivery of terazosin hydrochloride: design, development, and…
Abstract
The aim of the work. Terazosin HCL, which is a selective alpha-1 antagonist, has been recommended for the treatment of benign prostatic hyperplasia-related medical conditions, including hypertension and urinary tract disorders. The purpose of this research was to create microparticles that…
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Physicochemical characterization of the metamorphosis of film-forming formulations of…
Following topical application of a dermatological product, the loss (by evaporation and/or absorption through the skin) of volatile excipients will alter the composition of the formulation remaining on the tissue. This so-called metamorphosis impacts the concentration of the drug in the residual…
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