Pharma Excipients
Excipient for Inhalation
Manufacturing softpellets using triboelectric agglomeration of fine powders on a vibrated inclined…
Abstract
Fine powders are required in many industrial applications, but their poor flow properties make handling and processing challenging. In Dry Powder Inhalation (DPI), for instance, inhaled particles must have an aerodynamic diameter between 1 and 5 μm to ensure therapeutic efficiency.…
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Improving inhalation delivery of biologics with extra-large particles produced by spray freeze…
Abstract
Inhalation delivery of biologics as dry powders offers a promising alternative to liquid formulations, eliminating the need for cold storage. However, controlling particle properties for efficient lung delivery is challenging. While spray drying (SD) has been successfully used, it often…
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Experimental measurements of particle deposition in the human nasal airway
Abstract
Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition locations on deposition efficiency, they have not focused…
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Cannabidiol and Hydroxypropyl-β-Cyclodextrin for the Development of Deflated Spherical-Shaped…
Abstract
In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both…
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Optimization of formulation and device design for carrier-based nasal powder of influenza vaccine to…
Abstract
Previously, a nasal powder formulation of the influenza vaccine was proposed to ensure its stability over fifteen months at room temperature and to have sufficient moisture-resistant characteristics to enable handling without special humidity control. In this study, a carrier-based…
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Posaconazole nanocrystals dry powder inhalers for the local treatment of invasive pulmonary…
Abstract
Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients, characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole antifungal, exhibits broad-spectrum activity but suffers from limited pulmonary concentrations and notable…
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An Exploration of Dissolution Tests for Inhalation Aerosols
This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly…
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Spray Drying of mRNA Lipoplexes to Produce an Inhalable Dry Powder Formulation for mRNA Therapeutics
Introduction
Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions.
Liquid vaccines face the risk of chemical degradation and physical instability
-> Solid formulations can…
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Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for…
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue as public health concerns. Inhaled drug therapy for TB has substantial benefits in combating the causal agent of TB (Mycobacterium tuberculosis). Pretomanid is a promising candidate in an optional…
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Optimising the Aerodynamic Performance of Spray Dried mRNA Lipoplexes in Mannitol or Lactose Matrix
Introduction
Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions.
Liquid vaccines face the risk of chemical degradation and physical instability
-> Solid formulations can…
Read More...
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