Pharma Excipients
Film former
Addiction to Psychoactive Prescription Drugs: Can the Excipients of the Formulations Play a Role?
Abstract
In the development of drugs misuse and addiction, references are often made to the study of the API (active principle ingredient) as the main cause, which is certainly true, but there is a tendency to overlook the possible role of certain excipients which may be involved in the…
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Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study
The aim of this study was to evaluate the effect of film-forming polymer solutions of different concentrations and pH values, either associated or not with sodium fluoride (F; 225 ppm F−), when applied during the initial stage of salivary pellicle formation, to prevent the dissolution of…
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Orodispersible Films: Current Innovations and Emerging Trends
Abstract
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery…
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Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic…
Abstract
Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to provide adequate protection. This study is the first to…
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Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast…
Abstract
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline…
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In Vitro and In Vivo Evaluation of Composite Oral Fast Disintegrating Film: An Innovative Strategy…
Here, we evaluate the feasibility of co-loading plain ranitidine hydrochloride (RHCl) and microencapsulated flurbiprofen (FBP) in a Lycoat® RS780-based oral fast disintegrating film (ODF). These films were developed by the solvent casting method to minimize the adverse effects of FBP and reduce the…
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Integrated in vitro – In vivo – In silico studies in the pharmaceutical development of propranolol…
In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed. The aim of this study was the development,…
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Role of additives in starch-based edible films and coating: A review with current knowledge
Edible films and coating provide a potentially effective method for preserving fresh food products by reducing moisture loss, regulating respiration rate, improving surface smoothness, and or preventing microbial growth during their storage. Concurrently, starch has proven for its inexpensive,…
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Formulation and Characterization of Buccal Films Containing Valsartan with Additional Support from…
The present study was aimed to the development and characterization of valsartan-containing buccal films with an introduction to a novel technique of image analysis. Visual inspection of the film provided a wealth of information that was difficult to quantify objectively. The obtained images of the…
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Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and…
Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in…
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