Coating

The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor…
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The pressure to innovate faster than their competitors has drug formulators exploring new ways to optimise manufacturing processes Article in manufacturingchemist.com Continuous manufacturing, for example, has evolved at a relatively fast pace, leaving drug manufacturers feeling equally challenged…
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Oral modied-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form…
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This paper develops a methodology to estimate the break force of curved faced tablets under diametrical compression. Common excipients used in pharmaceutical tablet formulations, including microcrystalline cellulose, calcium phosphate and mannitol as well as their mixtures were characterised.…
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Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological…
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13. August 2018 The aim of this study is to determine favorable process conditions for the coating of placebo tablets. Tablets made of microcrystalline cellulose are coated with hydroxypropyl cellulose polymer and Advantia™ Prime polymeric mixture film in lab-scale…
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The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality bydesign (QbD) approach. The drug release rate of methimazole, a freely soluble model drug, was evaluated…
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21. July 2018 The Andrographis herba extract (AHE), a traditional Chinese medicine (TCM), was developed to directly compactible powders by fluid bed coating with 6% to 12% hydroxypropyl methylcellulose (HPMC). The process-, instrument-, and formulation-related…
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