Pellet

Abstract The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
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This poster was presented at the ECP 2025 in Porto Introduction Fig. 1. 20% drug-loaded particle microscopy before (A) and after (B) 360 minutes of thermal treatment, magnification (40x) Warfarin, a coumarin derivative, is an indirect-acting anticoagulant and a vitamin K…
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Powered By Innovation, Driving Health, Wellness & Healing The building of a “best in class” solutions provider starts with understanding the complexities of a customer’s need and identifying gaps. New technologies and Drug Delivery Systems are studied and appropriate excipients or raw-materials…
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In the realm of pharmaceutical formulations, the quest for efficient and reliable drug delivery systems has led to significant advancements. Among these, CELLETS®—highly spherical microcrystalline cellulose (MCC) pellets—have emerged as a pivotal component in developing multiparticulate dosage forms…
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Abstract The aim of this study was to investigate the feasibility of coated pellet formulation by high shear mixing of drug pellets and polymer particles without solvent or heat. First, drug-layered pellets were prepared by high shear mixing of drug crystals and sugar-cellulose pellets. Second,…
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Abstract In this study, an artificial intelligence-based machine vision system was developed for in-line particle size analysis during the pellet layering process. Drug-layered pellets were produced by coating microcrystalline cellulose cores with an ibuprofen-containing layering liquid until the…
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Abstract It is desirable but remains challenging to develop high drug load amorphous solid dispersions (ASDs) without compromising their quality attributes and bio-performance. In this work, we investigated the impacts of formulation variables, such as drug loading (DL) and polymer type, on…
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Abstract Congenital diaphragmatic hernia (CDH) is a rare disease in which neonates are born with pulmonary hypoplasia and a diaphragmatic defect. Survival is improving due to advances in fetal intervention for pulmonary hypoplasia leading to increased use of scaffolds for repair. Scaffolds have a…
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Abstract Background and Purpose Liquid self-nanoemulsifying drug delivery systems (SNEDDS) face challenges related to stability, handling, and storage. In particular, lipophilic and unstable drugs, such as ramipril (RMP) and thymoquinone (THQ), face challenges in oral administration due to poor…
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The patent application US20240350420A1 focuses on pharmaceutical formulations and methods for treating conditions such as hyperhidrosis, which involves excessive sweating. The document details the development of modified-release compositions, specifically utilizing Pilocarpine HCl, a muscarinic…
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