Pharma Excipients
Pellet
Effects of alginate inclusion on quality attributes and storage stability of gelatin oral pellets…
Abstract
Ionic liquid (IL) salts of active pharmaceutical ingredients (API) represent promising formulations for poorly-soluble APIs as they eliminate polymorphism commonly associated with conventional API salts. Being highly viscous liquid, oral dosage formulation of API-ILs is challenging,…
Read More...
Read More...
Preparation of self-dispersible eutectic mixtures for poorly soluble drugs: Hot-melt extrusion vs.…
Abstract
Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in terms of processability and dissolution rate at, below, and above the eutectic concentration. Furthermore, the effects…
Read More...
Read More...
A universal digital control concept for end-to-end manufacturing
Abstract
With the implementation of advanced manufacturing concepts (e.g., continuous operation, integration of different process routes and modular manufacturing), control of the process and the related product quality becomes more complex. Unlike traditional in-process controls and end-product…
Read More...
Read More...
A novel orodispersible film load with dual-coated sustained-release microparticles for pediatric…
Abstract
Orodispersible films (ODFs), easy to administer, flexible in dosage, and free of choking and aspiration risks, have drawn widespread attention as pediatric formulations. However, it is a great challenge to endow ODFs with sustained release due to their fast disintegration. Herein, we…
Read More...
Read More...
Manufacturing softpellets using triboelectric agglomeration of fine powders on a vibrated inclined…
Abstract
Fine powders are required in many industrial applications, but their poor flow properties make handling and processing challenging. In Dry Powder Inhalation (DPI), for instance, inhaled particles must have an aerodynamic diameter between 1 and 5 μm to ensure therapeutic efficiency.…
Read More...
Read More...
Development and optimization of mucoadhesive sustained-release chlorothiazide pellets for improved…
Abstract
Chlorothiazide (CTZ), a widely used thiazide diuretic, exhibits poor and variable oral bioavailability due to site-specific absorption and carrier-mediated saturable transport in the upper gastrointestinal tract. This study aimed to develop mucoadhesive controlled-release pellets of CTZ to…
Read More...
Read More...
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with…
Abstract
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places a significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer a promising alternative for…
Read More...
Read More...
Engineering pH-Dependent Orally Disintegrating Tablets for Modified Indomethacin Release: A…
Abstract
The application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating…
Read More...
Read More...
Taste-masked pellets of sodium warfarin prepared by hot melt extrusion – ECP 2025 Poster
This poster was presented at the ECP 2025 in Porto
Introduction
Fig. 1. 20% drug-loaded particle microscopy before (A) and after (B) 360 minutes of thermal treatment, magnification (40x)
Warfarin, a coumarin derivative, is an indirect-acting anticoagulant and a vitamin K…
Read More...
Read More...
Gangwal Healthcare – A solutions provider for Complex, Innovative & Cutting-edge…
Powered By Innovation, Driving Health, Wellness & Healing
The building of a “best in class” solutions provider starts with understanding the complexities of a customer’s need and identifying gaps. New technologies and Drug Delivery Systems are studied and appropriate excipients or raw-materials…
Read More...
Read More...