Pellet

Abstract Omeprazole (OM), a temperature, pH, and moisture-sensitive drug, poses formulation challenges. This study delves into the complex development of OM pellets, focusing on the impact of buffering excipients on stability and release. Addressing the challenges of OM pellet stability requires a…
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Introduction Pellets are versatile dosage forms for many actives. To control drug dissolution profiles, they can be prepared with different coatings. Coated multiparticulate systems are known to show less variation in drug release than single unit formulations. Furthermore, dose dumping effects due…
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Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease…
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Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides are degraded by colonic enzymes (secreted by bacteria), triggering the…
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Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide, and non-adherence to adjuvant hormonotherapy can negatively impact cancer recurrence and relapse. Non-adherence is associated with side effects of hormonotherapy. Pharmacological strategies to mitigate the side…
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ABSTRACT Background Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention. Aim This study aimed to develop…
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Brain drug delivery is severely hindered by the presence of the blood–brain barrier (BBB). Its functionality relies on the interactions of the brain endothelial cells with additional cellular constituents, including pericytes, astrocytes, neurons, or microglia. To boost brain drug delivery,…
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Abstract Purpose Posaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent solubility. Method The present investigation was aimed to formulate and evaluate liquisolid pellets of PSZ for improving its…
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Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality improvement. The PHARMACOAT® grades are low viscous…
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Abstract The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as…
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